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公开(公告)号：WO2008089339A3
公开(公告)日：2008-09-18
申请号：PCT/US2008051327
申请日：2008-01-17
Applicant: GENZYME CORP , LEE KAREN L , MATTALIANO ROBERT J , STEFANO JAMES E
Inventor： LEE KAREN L , MATTALIANO ROBERT J , STEFANO JAMES E
Abstract: This disclosure relates to conjugation of therapeutic proteins (e.g., lysosomal enzymes) with oligosaccharides comprising mannose-6-phosphate. Conjugation of proteins with oligosaccharides comprising mannose-6-phosphate results in protein-oligosaccharide conjugates that are targeted to the lysosome by mannose-6-phosphate receptors. The proteins of the invention may be used in enzyme replacement therapy of, e.g., lysosomal storage disorders.
Abstract translation: 本公开涉及治疗性蛋白质（例如溶酶体酶）与包含甘露糖-6-磷酸的寡糖的缀合。 蛋白质与包含甘露糖-6-磷酸的寡糖的缀合产生蛋白质 - 寡糖缀合物，其通过甘露糖-6-磷酸受体靶向溶酶体。 本发明的蛋白质可用于例如溶酶体贮积症的酶替代疗法。
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公开(公告)号：WO2009151708A3
公开(公告)日：2010-11-18
申请号：PCT/US2009037809
申请日：2009-03-20
Applicant: GENZYME CORP , PERRICONE MICHAEL A , DZURIS JOHN LYLE , WEEDEN TIMOTHY E , STEFANO JAMES E , PAN CLARK Q , EDLING ANDREA E
Inventor： PERRICONE MICHAEL A , DZURIS JOHN LYLE , WEEDEN TIMOTHY E , STEFANO JAMES E , PAN CLARK Q , EDLING ANDREA E
CPC classification number: C07K14/685 , A61K38/00 , A61K38/34 , A61K47/48246 , A61K47/64 , A61K49/0008 , C07K5/1021 , C07K5/1024 , C07K7/08
Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (a-MSH) having selectivity for the melanocortin 1 receptor (MClR). Also provided herein are pharmaceutical preparations of the a-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MClR.
Abstract translation: 本文提供了对黑皮质素1受体（MClR）具有选择性的天然α-黑素细胞刺激激素（a-MSH）的稳定肽类似物。 本文还提供了a-MSH肽类似物的药物制剂，以及使用这些类似物来治疗涉及MClR的医学和兽医病症的方法。
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Patent Agency Ranking
公开(公告)号：WO2010075010A2
公开(公告)日：2010-07-01
申请号：PCT/US2009/067775
申请日：2009-12-11
Applicant: GENZYME CORPORATION , PAN, Clark , KONOWICZ, Paul, A. , AVILA, Luis, Z. , STEFANO, James, E. , REARDON, Michael, R. , HARRAHY, John , ZHOU, Qun , YOUNG, Lauren , FINN, Patrick , ZHENG, Xiaoyang , MILLER, Robert, J. , KUTZKO, Joseph
Inventor： PAN, Clark , KONOWICZ, Paul, A. , AVILA, Luis, Z. , STEFANO, James, E. , REARDON, Michael, R. , HARRAHY, John , ZHOU, Qun , YOUNG, Lauren , FINN, Patrick , ZHENG, Xiaoyang , MILLER, Robert, J. , KUTZKO, Joseph
Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide- glycoprotein conjugate.
Abstract translation: 本文提供包含蛋白质和式I-VI之一的寡糖的缀合物。 本文还提供包含这种缀合物的药物组合物。 本文还提供了通过施用寡糖 - 糖蛋白缀合物来治疗哺乳动物中的溶酶体贮积病症的方法。
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公开(公告)号：WO0109384A3
公开(公告)日：2001-06-07
申请号：PCT/US0020557
申请日：2000-07-28
Applicant: GENZYME CORP , STEFANO JAMES E
Inventor： STEFANO JAMES E
IPC: C12Q1/68
CPC classification number: C12Q1/6855 , C12Q1/6809
Abstract: Methods and compositions for the rapid detection and identification of multiple genetic alterations are provided.
Abstract translation: 提供了用于快速检测和鉴定多种遗传改变的方法和组合物。
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公开(公告)号：WO2009151708A2
公开(公告)日：2009-12-17
申请号：PCT/US2009/037809
申请日：2009-03-20
Applicant: GENZYME CORPORATION , PERRICONE, Michael, A. , DZURIS, John, Lyle , WEEDEN, Timothy, E. , STEFANO, James, E. , PAN, Clark, Q. , EDLING, Andrea, E.
Inventor： PERRICONE, Michael, A. , DZURIS, John, Lyle , WEEDEN, Timothy, E. , STEFANO, James, E. , PAN, Clark, Q. , EDLING, Andrea, E.
CPC classification number: C07K14/685 , A61K38/00 , A61K38/34 , A61K47/48246 , A61K47/64 , A61K49/0008 , C07K5/1021 , C07K5/1024 , C07K7/08
Abstract: Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (α-MSH) having selectivity for the melanocortin 1 receptor (MClR). Also provided herein are pharmaceutical preparations of the α-MSH peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving MClR.
Abstract translation: 本文提供了对黑皮质素1受体（MClR）具有选择性的天然α-黑素细胞刺激激素（a-MSH）的稳定肽类似物。 本文还提供了a-MSH肽类似物的药物制剂，以及使用这些类似物来治疗涉及MClR的医学和兽医病症的方法。
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公开(公告)号：WO2010075010A3
公开(公告)日：2011-01-06
申请号：PCT/US2009067775
申请日：2009-12-11
Applicant: GENZYME CORP , PAN CLARK , KONOWICZ PAUL A , AVILA LUIS Z , STEFANO JAMES E , REARDON MICHAEL R , HARRAHY JOHN , ZHOU QUN , YOUNG LAUREN , FINN PATRICK , ZHENG XIAOYANG , MILLER ROBERT J , KUTZKO JOSEPH
Inventor： PAN CLARK , KONOWICZ PAUL A , AVILA LUIS Z , STEFANO JAMES E , REARDON MICHAEL R , HARRAHY JOHN , ZHOU QUN , YOUNG LAUREN , FINN PATRICK , ZHENG XIAOYANG , MILLER ROBERT J , KUTZKO JOSEPH
Abstract: Provided herein are conjugates comprising a protein and an oligosaccharide of one of Formulae I-VI. Also provided herein are pharmaceutical compositions comprising such conjugates. Further provided herein are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide- glycoprotein conjugate.
Abstract translation: 本文提供包含蛋白质和式I-VI之一的寡糖的缀合物。 本文还提供包含这种缀合物的药物组合物。 本文还提供了通过施用寡糖 - 糖蛋白缀合物来治疗哺乳动物中的溶酶体贮积病症的方法。
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公开(公告)号：WO2008089339A2
公开(公告)日：2008-07-24
申请号：PCT/US2008/051327
申请日：2008-01-17
Applicant: GENZYME CORPORATION , LEE, Karen, L. , MATTALIANO, Robert, J. , STEFANO, James, E.
Inventor： LEE, Karen, L. , MATTALIANO, Robert, J. , STEFANO, James, E.
Abstract: This disclosure relates to conjugation of therapeutic proteins (e.g., lysosomal enzymes) with oligosaccharides comprising mannose-6-phosphate. Conjugation of proteins with oligosaccharides comprising mannose-6-phosphate results in protein-oligosaccharide conjugates that are targeted to the lysosome by mannose-6-phosphate receptors. The proteins of the invention may be used in enzyme replacement therapy of, e.g., lysosomal storage disorders.
Abstract translation: 本公开涉及治疗性蛋白质（例如溶酶体酶）与包含甘露糖-6-磷酸的寡糖的缀合。 蛋白质与包含甘露糖-6-磷酸的寡糖的结合导致通过甘露糖-6-磷酸受体靶向溶酶体的蛋白质 - 寡糖共轭物。 本发明的蛋白质可用于例如溶酶体贮积障碍的酶替代疗法。
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