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公开(公告)号：WO2022197608A1
公开(公告)日：2022-09-22
申请号：PCT/US2022/020192
申请日：2022-03-14
发明人： WALLACE, Zachary , LAURENCE, Lawton , ABEYGUNAWARDENA, Menaka , HRISTOFAS, Eleftherios , BASISTA, John
摘要： A method and system for creating an aseptic connection is disclosed. The method includes arranging a heating element between a first outer sealing surface and a second outer sealing surface such that the heating element is in contact with the first outer sealing surface and the second outer sealing surface. The method further includes applying opposing forces to the first and second outer sealing surfaces such that the first and second outer sealing surfaces are biased towards each other and heating the heating element to sterilize the first outer sealing surface and second outer sealing surface. The method also includes removing the heating element from between the first seal and second seal while continuing to apply the opposing forces to the first and second outer sealing surfaces such that the aseptic connection is simultaneously formed between the first and second outer sealing surfaces.
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公开(公告)号：WO2022104270A1
公开(公告)日：2022-05-19
申请号：PCT/US2021/059533
申请日：2021-11-16
发明人： WALLACE, Zachary , LAURENCE, Lawton Edward , ABEYGUNAWARDENA, Menaka , HYDE, Aidan , MAZZOTTA, Andrew , BROUGH, Richard James , PRATT, Spencer W. , WALKER, Nolan P. , SULLIVAN, Michael J.
摘要： Connection systems for injection devices are disclosed. Also disclosed are injection devices and methods of using the same. A connection system includes a first and second connection assembly and a coupling assembly to secure the same. The first connection assembly connects to a medicament container, and the second connection assembly has a needle movable toward the medicament container. Removable flexible barriers are disposed on the first and second connection assemblies and can be removed once the connection assemblies are coupled together to form an aseptic connection between the two assemblies. The needle can be moved toward the medicament container to pierce a septum on the container to form a fluid communication between the container and the needle.
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公开(公告)号：WO2022051176A1
公开(公告)日：2022-03-10
申请号：PCT/US2021/047868
申请日：2021-08-27
摘要： An injection device (10) includes a lower housing (18), a sleeve (32) supported by the lower housing, and a syringe spring (34) received within the sleeve. The spring supports a syringe (12). A needle guard (26) is proximally slidable relative to the lower housing from a first position, concealing the syringe needle (12b), to a second position. A needle guard spring (27) biases the needle guard distally relative to the lower housing. An upper housing (16) is distally slidable relative to the lower housing from a pre-use position to a dispensed position. Movement of the needle guard from the first position to the second position extends the distal tip of the needle distally beyond the needle guard by a first distance. Subsequent distal movement of the upper housing relative to the lower housing from the pre-use position toward the dispensed position advances the distal tip of the needle distally further beyond the needle guard by a second distance.
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公开(公告)号：WO2021211412A1
公开(公告)日：2021-10-21
申请号：PCT/US2021/026808
申请日：2021-04-12
摘要： An injection device is provided, which comprises a housing configured to receive a medicament container and a needle assembly coupled with the medicament container; and a safety mechanism configured, in response to completion of delivery of a dose of medicament from the medicament container, to retract the medicament container to a retracted position relative to the housing. The safety mechanism is further configured, in response to removal of the injection device from an injection site prior to completion of delivery of the dose of the medicament, to advance a safety component relative to the housing from a first position to a second position. A sub-assembly for an injection device is also provided, as well as associated methods of using the device.
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公开(公告)号：WO2021183103A1
公开(公告)日：2021-09-16
申请号：PCT/US2020/021701
申请日：2020-03-09
发明人： RECH, John , BANTZ, Daniel, L. , GUPTA, Varun
摘要： A method for determining a released particle count for parts intended for pharmaceutical use is disclosed. The method comprises the steps of: (i) introducing a sample of parts into a receptacle; (ii) rinsing the one or more parts by introducing a volume of rinse fluid into the receptacle; (iii) draining the rinse fluid from the receptacle via the collection outlet and delivering the rinse fluid from the collection outlet to a detection conduit; (iv) capturing at least one image of the fluid in a detection region of the detection conduit; (v) identifying a number of particles in the at least one detection region using automatic image analysis of the at least one captured image; (vi) determining a released particle count for the sample of parts based on the at least one captured image. Systems for determining a released particle count are also provided.
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公开(公告)号：WO2021150340A1
公开(公告)日：2021-07-29
申请号：PCT/US2020/066505
申请日：2020-12-22
IPC分类号： A61M5/14 , A61M5/19 , A61M5/168 , A61M5/00 , A61M5/178 , A61M2005/006 , A61M2005/1787 , A61M2202/02 , A61M5/1408 , A61M5/16827
摘要： A parenteral injection device comprises a housing defining an internal cavity and an output, a first reservoir disposed within the internal cavity, where the first reservoir defines a first chamber that is configured to store a drug and is in fluid communication with the output, a first drive mechanism to selectively force the drug from the first chamber, and a second reservoir disposed within the internal cavity, wherein the second reservoir defines a second chamber that is configured to store a gas and is in fluid communication with the output. The injection device further comprises a second drive mechanism to selectively force the gas from the second chamber, and a controller in signal communication with the first and second drive mechanisms, such that the controller is configured to selectively direct the first and second drive mechanisms to force the drug and gas from the first and second chambers, respectively, to the output in a predetermined sequence.
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公开(公告)号：WO2021016328A1
公开(公告)日：2021-01-28
申请号：PCT/US2020/043031
申请日：2020-07-22
发明人： KOUTAL, Benny, Cyrus
摘要： A vial closure assembly (10) for sealing a container (12) includes a ring (28), a cap (32), a shell (70), and an optional cover (30). The ring has a first top wall (34) defining a first central through-opening (29) and a skirt (36) extending downwardly from the first top wall that includes a plurality of locking tabs. The cover includes a second top wall (54) defining a second central through-opening (58), a sidewall (56) extending downwardly from the second top wall, and an interior cavity (57) defined by the second top wall and the sidewall. The cap includes a plurality of tabs (66) configured to engage the first or second top wall. The shell includes a barrel-shaped body (71) having an inwardly radially extending upper (72) and lower lip (74), such that the shell is configured to captivate the cover or ring. The upper lip includes at least one rail (76) for sliding contact with a top surface of either the first or second top wall.
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公开(公告)号：WO2020051308A1
公开(公告)日：2020-03-12
申请号：PCT/US2019/049712
申请日：2019-09-05
发明人： ILLES, Steve , PATEL, Ravi
摘要： Methods and systems for measuring a component of a drug delivery or storage device are described. The method comprises providing a light source in an opposing relationship with an optical imaging sensor; positioning a sample component on a positioning stage located between the at least one light source and at least one opposing optical imaging sensor; and illuminating, with the at least one light source, the sample component. The controller is operable to capture an image of the component, determine the location of a first outer edge point PI of the captured image; rotate the sample component relative to the optical image sensor, and collect n images separated from each other by x degrees of rotation, wherein n*x is ≥ 360 degrees. The controller may compare a measured position of the at least one outer edge point PI between the captured images to determine a degree or circular runout.
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公开(公告)号：WO2019068109A1
公开(公告)日：2019-04-04
申请号：PCT/US2018/053819
申请日：2018-10-01
发明人： HEZKIAHU, Ran
IPC分类号： A61M5/24
摘要： A securing device for an injection device which receives a syringe with a proximal end portion having a radially outwardly projecting flange, has a body with proximal and distal end portions, an opening for accepting the syringe, an outer surface, and a proximal end surface for contacting a distally-facing surface of the flange when the syringe is advanced distally, preventing further advancement. A securing arm includes a free end; a base end fixed to the outer surface; a first portion extending radially outwardly from the base end to permit the flange to pass; and a second portion extending radially inwardly in a rest position, contacting the flange as the syringe is advanced. The securing arm is elastically flexible to allow the free end to move radially outwardly, allowing the advancing flange to pass, and is biased to the rest position to secure the flange and the syringe against proximal movement.
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公开(公告)号：WO2019032512A1
公开(公告)日：2019-02-14
申请号：PCT/US2018/045506
申请日：2018-08-07
发明人： YIGAL, Gil , BAR-EL, Yossi
IPC分类号： A61M5/24
摘要： An injector has a cartridge door movable between a fully closed position and a fully open position. A power supply is employed to power at least one power-operated component of the injector. A power supply circuit electrically connects the power supply with the at least one power- operated component. An electrically insulated arm is movable from a first state, in which the electrically insulated arm electrically disconnects the power supply from the circuit, to a second state, in which the electrically insulated arm connects the power supply with the circuit to provide power to the at least one power-operated component. The insulated arm is coupled to the cartridge door and initially positioned in the first state thereof in the fully closed position of the cartridge door, whereby movement of the cartridge door out of the fully closed position toward the fully open position moves the arm to the second state thereof.
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