公开(公告)号：WO2022232333A1

公开(公告)日：2022-11-03

申请号：PCT/US2022/026626

申请日：2022-04-28

申请人： MERCK SHARP & DOHME LLC ,  MSD R&D (CHINA) CO., LTD. ,  GIAMBASU, George Madalin ,  HAIDLE, Andrew, M. ,  HOPKINS, Brett, A. ,  JEWELL, James, P. ,  LARSEN, Matthew, A. ,  LESBURG, Charles, A. ,  LIU, Ping ,  PU, Qinglin ,  SANYAL, Sulagna ,  SILIPHAIVANH, Phieng ,  TUDOR, Matthew ,  WHITE, Catherine, M. ,  YAN, Xin ,  ZHAO, Lianyun ,  ZHENG, Xiao Mei ,  KAPLAN, William, P. ,  LUX, Michaelyn Claire ,  LI, Derun ,  JOHNSON, Rebecca

发明人： GIAMBASU, George Madalin ,  HAIDLE, Andrew, M. ,  HOPKINS, Brett, A. ,  JEWELL, James, P. ,  LARSEN, Matthew, A. ,  LESBURG, Charles, A. ,  LIU, Ping ,  PU, Qinglin ,  SANYAL, Sulagna ,  SILIPHAIVANH, Phieng ,  TUDOR, Matthew ,  WHITE, Catherine, M. ,  YAN, Xin ,  ZHAO, Lianyun ,  ZHENG, Xiao Mei ,  KAPLAN, William, P. ,  LUX, Michaelyn Claire ,  LI, Derun ,  JOHNSON, Rebecca

IPC分类号： A61P35/00 ,  C07D241/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D403/14 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06 ,  C07D417/10 ,  C07D417/14 ,  A61K31/501 ,  A61K31/496 ,  A61K31/506 ,  A61K31/495

摘要： Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, L, X and Y are as defined herein. The compounds of Formula (I) act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases. Also provided herein are pharmaceutical compositions comprising the compounds of the invention, or their pharmaceutically acceptable salts, and a pharmaceutically acceptable carrier and methods of treatment with the compounds of the invention.

公开(公告)号：WO2019074747A1

公开(公告)日：2019-04-18

申请号：PCT/US2018/054273

申请日：2018-10-04

申请人： MERCK SHARP & DOHME CORP. ,  MCGOWAN, Meredeth Ann ,  ACHAB, Abdelghani ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  SCIAMMETTA, Nunzio ,  WHITE, Catherine, M. ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

发明人： MCGOWAN, Meredeth Ann ,  ACHAB, Abdelghani ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  SCIAMMETTA, Nunzio ,  WHITE, Catherine, M. ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

IPC分类号： A61K31/166 ,  C07C13/06 ,  C07C233/65

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：WO2021226003A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/030541

申请日：2021-05-04

申请人： MERCK SHARP & DOHME CORP. ,  CASH, Brandon, D. ,  FU, Wenlang ,  GIAMBASU, George Madalin ,  HAIDLE, Andrew, M. ,  HOPKINS, Brett, A. ,  LARSEN, Matthew, A. ,  LESBURG, Charles, A. ,  LIU, Ping ,  MCGOWAN, Meredeth, A. ,  PU, Qinglin ,  SANYAL, Sulagna ,  SILIPHAIVANH, Phieng ,  WHITE, Catherine, M. ,  YAN, Xin

发明人： CASH, Brandon, D. ,  FU, Wenlang ,  GIAMBASU, George Madalin ,  HAIDLE, Andrew, M. ,  HOPKINS, Brett, A. ,  LARSEN, Matthew, A. ,  LESBURG, Charles, A. ,  LIU, Ping ,  MCGOWAN, Meredeth, A. ,  PU, Qinglin ,  SANYAL, Sulagna ,  SILIPHAIVANH, Phieng ,  WHITE, Catherine, M. ,  YAN, Xin

IPC分类号： C07D403/10 ,  C07D235/26 ,  C07D401/06 ,  C07D401/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D409/06 ,  C07D413/10 ,  C07D417/10 ,  C07D419/10 ,  C07D495/04 ,  A61K31/4184 ,  A61P35/00 ,  C07D409/14

摘要： Described herein are compounds of Formula I or a pharmaceutically acceptable salt thereof. The compounds of Formula I act as IL4I1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for IL4I1-related diseases.

公开(公告)号：WO2019074749A1

公开(公告)日：2019-04-18

申请号：PCT/US2018/054276

申请日：2018-10-04

申请人： MERCK SHARP & DOHME CORP. ,  WHITE, Catherine M. ,  ACHAB, Abdelghani ,  BHARATHAN, Indu T. ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  MCGOWAN, Meredeth Ann ,  SCIAMMETTA, Nunzio ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

发明人： WHITE, Catherine M. ,  ACHAB, Abdelghani ,  BHARATHAN, Indu T. ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  MCGOWAN, Meredeth Ann ,  SCIAMMETTA, Nunzio ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

IPC分类号： A61K31/166 ,  C07C13/06 ,  C07C233/65

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.