公开(公告)号：WO2014055548A1

公开(公告)日：2014-04-10

申请号：PCT/US2013/062910

申请日：2013-10-01

申请人： INTERMUNE, INC.

发明人： BUCKMAN, Brad Owen ,  NICHOLAS, John Beamond ,  RAMPHAL, Johnnie Y. ,  EMAYAN, Kumaraswamy ,  SEIWERT, Scott D.

IPC分类号： C07D495/04 ,  C07D211/86 ,  C07D401/04 ,  C07D221/04 ,  C07D471/04 ,  C07D513/04 ,  C07D498/04 ,  C07D209/34 ,  C07D417/12 ,  C07D409/12 ,  C07D401/12 ,  C07D401/14 ,  C07D417/14 ,  C07D409/14 ,  C07D413/14 ,  C07D405/04 ,  C07D417/10 ,  C07D413/04 ,  C07D405/14 ,  C07D487/04 ,  C07D417/04 ,  C07D211/84 ,  C07D403/04 ,  C07D237/14 ,  C07D491/048 ,  C07D473/06 ,  C07D473/28 ,  C07D205/08 ,  C07D209/38 ,  C07D223/10 ,  C07D209/48 ,  C07D207/267 ,  C07D211/76 ,  C07C13/06 ,  C07D473/32 ,  A61K31/4035 ,  A61K31/427 ,  A61K31/381 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/501 ,  A61K31/513 ,  A61K31/522 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/539 ,  A61K31/541 ,  A61P1/16 ,  A61P11/00 ,  A61P17/02 ,  A61P19/04

CPC分类号： A61K31/437 ,  A61K9/007 ,  C07D211/86 ,  C07D213/64 ,  C07D217/24 ,  C07D221/04 ,  C07D223/10 ,  C07D295/125 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

摘要： Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

摘要翻译： 公开了吡啶酮化合物，这些化合物的制备方法和治疗纤维化疾病的方法。

公开(公告)号：WO2013181697A1

公开(公告)日：2013-12-12

申请号：PCT/AU2013/000591

申请日：2013-06-05

申请人： THE UNIVERSITY OF MELBOURNE

发明人： WILLIAMS, Spencer John ,  DONNELLY, Paul Stephen ,  MULVANEY, Paul ,  SCHIEBER, Christine ,  JIMENEZ, Isaac Ojea

IPC分类号： C07C13/45 ,  C07C243/10 ,  A61K49/00 ,  C07C275/10 ,  C07D213/81 ,  C07C233/67 ,  C07C231/02 ,  C07C13/06

CPC分类号： A61K49/0056 ,  A61K49/0041 ,  A61K49/0067 ,  C07B2200/11 ,  C07C271/16 ,  C07C281/06 ,  C07C2601/04 ,  C07C2602/24 ,  C07D213/82 ,  G01N33/54353

摘要： The present invention relates to compounds that can be used link substrates to molecules, typically for biological applications such as imaging and the like. The compounds contain a cyclooctyne which is joined, via a linking group, to a moiety such as a squarate, amine, aminooxy, hydrazide, semicarbazide or carbohydrazide. The cyclooctyne moiety acts as the coupling partner to an azide-functionalised substrate or molecule, whilst the other moiety acts as the coupling partner to an amine-, aldehyde- or ketone-functionalised molecule or substrate. The invention therefore also relates to processes of synthesis of such compounds and further use of the compounds to link a substrate to a molecule.

摘要翻译： 本发明涉及可以将基质连接到分子上的化合物，通常用于生物学应用如成像等。 化合物含有环辛烯，其通过连接基团连接到诸如方酸，胺，氨基氧基，酰肼，氨基脲或碳酰肼的部分。 环辛炔部分作为叠氮化物官能化底物或分子的偶合配偶体，而另一部分用作胺，醛或酮官能化分子或底物的偶合配偶体。 因此，本发明还涉及合成这些化合物的方法以及化合物进一步使用以将底物连接到分子上。

公开(公告)号：WO2023010000A1

公开(公告)日：2023-02-02

申请号：PCT/US2022/074139

申请日：2022-07-26

申请人： BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE

发明人： NICHOLS, Charles

IPC分类号： C07C217/54 ,  A61K31/137 ,  A61P25/24 ,  C07C13/06 ,  A61P29/00

摘要： The invention features indolealkylamine compounds and pharmaceutical compositions useful for treating 5-HT2 responsive conditions. Also provided are methods of using the compounds or compositions of the invention for treating 5-HT2 responsive conditions such as depression or inflammation in a subject in need thereof.

公开(公告)号：WO2019074747A1

公开(公告)日：2019-04-18

申请号：PCT/US2018/054273

申请日：2018-10-04

申请人： MERCK SHARP & DOHME CORP. ,  MCGOWAN, Meredeth Ann ,  ACHAB, Abdelghani ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  SCIAMMETTA, Nunzio ,  WHITE, Catherine, M. ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

发明人： MCGOWAN, Meredeth Ann ,  ACHAB, Abdelghani ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  SCIAMMETTA, Nunzio ,  WHITE, Catherine, M. ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

IPC分类号： A61K31/166 ,  C07C13/06 ,  C07C233/65

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：WO2013181155A1

公开(公告)日：2013-12-05

申请号：PCT/US2013/042897

申请日：2013-05-28

申请人： NUTECH VENTURES

发明人： SITTIWONG, Wantanee ,  DUSSAULT, Patrick H. ,  BARLETTA, Raul ,  POWERS, Robert

IPC分类号： C07C53/134 ,  C07C49/39 ,  C07C13/06

CPC分类号： C07C59/21 ,  C07C51/09 ,  C07C53/134 ,  C07C57/26 ,  C07C59/11 ,  C07C59/205 ,  C07C67/313 ,  C07C2601/04 ,  C08F132/04 ,  C08F212/08 ,  C08F216/165 ,  C08F232/04

摘要： This disclosure relates to amphiphilic compounds containing a cyclobutene or cyclobutane moiety. In some embodiments, the compounds are useful for treating infection by Mycobacterium such as Mycobacterium tuberculosis. Cyclobutene containing compounds are also useful as monomers in the preparation of amphiphilic polymers.

摘要翻译： 本公开涉及含有环丁烯或环丁烷部分的两亲化合物。 在一些实施方案中，所述化合物可用于治疗结核分枝杆菌（Mycobacterium tuberculosis）等分枝杆菌感染。 含有环烯的化合物也可用作制备两亲性聚合物的单体。

公开(公告)号：WO2021064724A1

公开(公告)日：2021-04-08

申请号：PCT/IL2020/051058

申请日：2020-09-29

申请人： STOCKTON (ISRAEL) LTD.

发明人： GLICK, Alon

IPC分类号： A01N65/00 ,  C07C13/06 ,  A01N27/00

摘要： The present invention relates to protopanaxatriol (PPT)-type compounds and compositions comprising thereof useful for controlling insect infestations on plants. The present invention also relates to methods for treating, controlling and/or preventing insect infestation on a plant comprising applying a protopanaxatriol-type compound or a composition comprising thereof onto the plant or a part of the plant.

公开(公告)号：WO2019231871A1

公开(公告)日：2019-12-05

申请号：PCT/US2019/034089

申请日：2019-05-28

申请人： MERCK SHARP & DOHME CORP. ,  HE, Shuwen ,  HAN, Yongxin ,  PASTERNAK, Alexander

发明人： HE, Shuwen ,  HAN, Yongxin ,  PASTERNAK, Alexander

IPC分类号： A61K31/166 ,  C07C13/06 ,  C07C233/65

摘要： Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：WO2019074749A1

公开(公告)日：2019-04-18

申请号：PCT/US2018/054276

申请日：2018-10-04

申请人： MERCK SHARP & DOHME CORP. ,  WHITE, Catherine M. ,  ACHAB, Abdelghani ,  BHARATHAN, Indu T. ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  MCGOWAN, Meredeth Ann ,  SCIAMMETTA, Nunzio ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

发明人： WHITE, Catherine M. ,  ACHAB, Abdelghani ,  BHARATHAN, Indu T. ,  FRADERA, Xavier ,  HAN, Yongxin ,  LI, Derun ,  LIM, Jongwon ,  LIU, Kun ,  MCGOWAN, Meredeth Ann ,  SCIAMMETTA, Nunzio ,  YU, Wensheng ,  ZHANG, Hongjun ,  ZHOU, Hua

IPC分类号： A61K31/166 ,  C07C13/06 ,  C07C233/65

摘要： Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：WO2014202399A1

公开(公告)日：2014-12-24

申请号：PCT/EP2014/061738

申请日：2014-06-05

申请人： NOVALED GMBH

发明人： BOUAZZA, Sofiane ,  BOBBIO, Carla ,  WERNER, Ansgar

IPC分类号： H01M4/60 ,  H01M10/052 ,  C07C13/04 ,  C07C13/06 ,  C07C49/39 ,  C07C49/593 ,  C07C251/20

CPC分类号： H01M4/60 ,  C07C255/31 ,  C07C255/61 ,  C07C2601/02 ,  C07C2601/04 ,  H01M4/382 ,  H01M10/052 ,  H01M10/0525 ,  H01M2220/20 ,  H01M2220/30 ,  Y02T10/7011

摘要： The present invention relates to a battery comprising at least one electrochemical cell comprising a first electrode, a second electrode, a first electroactive material, a second electroactive material and an electrolyte which is in contact with both electrodes, wherein at least one of the first electroactive material and the second electroactive material comprises a radialene compound; to an electroactive material as well as to a compound therefore.

摘要翻译： 本发明涉及一种电池，其包括至少一个电化学电池，其包括第一电极，第二电极，第一电活性材料，第二电活性材料和与两个电极接触的电解质，其中至少一个第一电活性 材料和第二电活性材料包括一种径向烯化合物; 因此，电活性物质以及化合物。

公开(公告)号：WO2008023657A1

公开(公告)日：2008-02-28

申请号：PCT/JP2007/066099

申请日：2007-08-20

申请人： コニカミノルタビジネステクノロジーズ株式会社 ,  大福 幸司

发明人： 大福 幸司

IPC分类号： G03G9/09 ,  C07C13/06 ,  C09B23/00 ,  G03G9/097

CPC分类号： C09B57/007 ,  G03G9/0916

摘要： Disclosed is a toner for electrophotography which has no problem about the dispersibility into a thermoplastic resin, can enables good color development, and has excellent transparency, color reproduction property, heat resistance, charge distribution property and offset resistance. Also disclosed is a method for forming an image by using the toner. Further disclosed is a novel squarylium dye. The toner comprises a dye represented by the general formula (1).

摘要翻译： 公开了一种电子照相用调色剂，其对于热塑性树脂的分散性没有问题，可以实现良好的显色性，并且具有优异的透明性，色再现性，耐热性，电荷分布性和抗偏移性。 还公开了通过使用调色剂形成图像的方法。 进一步公开了一种新颖的方酸染料。 调色剂包含由通式（1）表示的染料。