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    MULTIPLE FLOW PATH MICROREACTOR DESIGN
    1.
    发明申请
    MULTIPLE FLOW PATH MICROREACTOR DESIGN 审中-公开
    多流程路径微处理器设计

    公开(公告)号：WO2010037012A3

    公开(公告)日：2010-08-19

    申请号：PCT/US2009058581

    申请日：2009-09-28

    Applicant: CORNING INC ,  GUIDAT ROLAND ,  LAVRIC ELENA D ,  LOBET OLIVIER ,  WOEHL PIERRE

    Inventor： GUIDAT ROLAND ,  LAVRIC ELENA D ,  LOBET OLIVIER ,  WOEHL PIERRE

    IPC: B01F5/02 ,  B01F5/06 ,  B01F13/00 ,  B01J19/00

    CPC classification number: B01F5/0641 ,  B01F5/0603 ,  B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F5/0655 ,  B01F13/0059 ,  B01F2005/0022 ,  B01F2005/0621 ,  B01F2005/0636 ,  B01L3/502746 ,  B01L2300/0816 ,  B01L2400/08 ,  B01L2400/086 ,  Y10T137/8593

    Abstract: A microfluidic device comprises at least one reactant passage (26) defined by walls and comprising at least one parallel multiple flow path configuration (50) comprising a group of elementary design patterns (34) being able to provide mixing and/or residence time which are arranged in series with fluid communication so as to constitute flow paths (52), and in parallel so as to constitute a multiple flow path elementary design pattern (57), wherein the parallel multiple flow path configuration (50) comprises at least two communicating zones (54) between elementary design patterns (34) of two adjacent parallel flow paths (52), said communicating zones (54) being in the same plane as that defined by said elementary design patterns (34) between which said communicating zone (54) is placed and allowing passage of fluid in order to minimize mass flow rate difference between adjacent parallel flow paths (52) which have the same flow direction.

    Abstract translation: 微流体装置包括由壁限定的至少一个反应物通道（26），并且包括至少一个平行的多个流路构造（50），其包括一组基本设计图案（34），其能够提供混合和/或停留时间， 与流体连通地串联地构成流路（52）并且并联地构成多流路基本设计图案（57），其中并行多流路构造（50）包括至少两个连通区域 （54）在两个相邻的平行流动路径（52）的基本设计图案（34）之间，所述连通区域（54）在与所述基本设计图案（34）所限定的相同的平面内，所述连通区域（54） 被放置并允许流体通过，以便使具有相同流动方向的相邻平行流路（52）之间的质量流量差最小化。

    INJECTOR ASSEMBLIES AND MICROREACTORS INCORPORATING THE SAME
    2.
    发明申请
    INJECTOR ASSEMBLIES AND MICROREACTORS INCORPORATING THE SAME 审中-公开
    注射器组件和微型计算机

    公开(公告)号：WO2009110990A1

    公开(公告)日：2009-09-11

    申请号：PCT/US2009/001265

    申请日：2009-02-27

    Applicant: CORNING INCORPORATED ,  LOBET, Olivier ,  POISSY, Stephane ,  WOEHL, Pierre

    Inventor： LOBET, Olivier ,  POISSY, Stephane ,  WOEHL, Pierre

    IPC: B01F13/02

    CPC classification number: B01J19/0093 ,  B01F3/0446 ,  B01F5/0077 ,  B01F5/045 ,  B01J4/002 ,  B01J2219/0081 ,  B01J2219/0086 ,  B01J2219/00891 ,  B05B7/0433

    Abstract: A microreactor assembly (100) is provided comprising a fluidic microstructure (10) and an injector assembly (20). The injector assembly (20) comprises a liquid inlet (22), a gas inlet (24), a liquid outlet (26), a gas outlet (28), a liquid flow portion (30) extending from the liquid inlet (22) to the liquid outlet (26), and a gas flow portion (40) extending from the gas inlet (24) to the gas outlet (28). Further, the injector assembly (20) defines an injection interface with a microchannel input port (14) of the fluidic microstructure (10). The injector assembly (20) is configured such that the gas outlet (28) of the gas flow portion (40) is positioned to inject gas into the liquid flow portion (30) upstream of the liquid outlet (26), into the liquid flow portion (30) at the liquid outlet (26), or into an extension (35) of the liquid flow portion (30) downstream of the liquid outlet (26). Further, the injector assembly (20) is configured such that gas is injected into the liquid flow portion (30) or the extension thereof as a series of gas bubbles. The resulting microreactor assembly (100), and the injector assemblies utilized therein, which can be used with a variety of microreactor designs, effectively improves the interfacial surface area within the microstructure without requiring excessive reduction of microchannel dimensions.

    Abstract translation: 提供了包括流体微结构（10）和喷射器组件（20）的微反应器组件（100）。 喷射器组件（20）包括液体入口（22），气体入口（24），液体出口（26），气体出口（28），从液体入口（22）延伸的液体流动部分（30） 到液体出口（26）和从气体入口（24）延伸到气体出口（28）的气体流动部分（40）。 此外，喷射器组件（20）限定与流体微结构（10）的微通道输入端口（14）的注入界面。 喷射器组件（20）构造成使得气体流动部分（40）的气体出口（28）定位成将气体喷射到液体出口（26）上游的液体流动部分（30）中，进入液体流 在液体出口（26）处的部分（30），或液体出口（26）下游的液体流动部分（30）的延伸部（35）中。 此外，喷射器组件（20）构造成使得气体作为一系列气泡被喷射到液体流动部分（30）或其延伸部分中。 可以与各种微反应器设计一起使用的所得微反应器组件（100）和其中使用的喷射器组件有效地改善了微结构内的界面表面积，而不需要过度减小微通道尺寸。

    MICROFLUIDIC SELF-SUSTAINING OSCILLATING MIXERS AND DEVICES AND METHODS UTILIZING SAME
    3.
    发明申请
    MICROFLUIDIC SELF-SUSTAINING OSCILLATING MIXERS AND DEVICES AND METHODS UTILIZING SAME 审中-公开
    微流控自动振荡混合器及其使用方法

    公开(公告)号：WO2008143923A1

    公开(公告)日：2008-11-27

    申请号：PCT/US2008/006219

    申请日：2008-05-15

    Applicant: CORNING INCORPORATED ,  WOEHL, Pierre

    Inventor： WOEHL, Pierre

    IPC: B01F11/00

    CPC classification number: B01F5/02 ,  B01F5/0602 ,  B01F5/0603 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/0094 ,  B01F13/1013 ,  B01F13/1016 ,  B01F15/06 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/00862 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0093 ,  B01J2219/00932 ,  B01J2219/00934 ,  B01J2219/00952 ,  B01J2219/00975

    Abstract: A microfluidic device (10) for performing chemical or biological reactions comprises a chamber (20) for use as a self-sustaining oscillating jet mixing chamber and two or more separate feed channels (22, 24, 40) separated by one or more inter-channel walls (25), the two or more channels (22,24,40) terminating at a common side (18) of the chamber (20), the two or more channels (22,24,40) having a total channel width (28) comprising the widths of the two or more channels (22,24,40) and all inter-channel walls (25) taken together, the chamber (20) having a width (26) in a direction perpendicular to the channels (22,24,40) and a length (32) in a direction parallel to the channels, the width (26) being at least two times the total channel width (28), the chamber (20) having two opposing major surfaces (56) defining a height (30) thereof, the chamber (20) having a major-surface-area to volume ratio of at least 10 cm2/cm3. A method of microfluidic fluid mixing using a self-sustaining oscillating jet mixing chamber is also disclosed.

    Abstract translation: 用于进行化学或生物反应的微流体装置（10）包括用作自持式振荡喷射混合室的两个或多个分离的进料通道（22,24,40）的腔室（20） 通道壁（25），两个或多个通道（22,24,40）终止于腔室（20）的共同侧（18）处，两个或多个通道（22,24,40）具有总通道宽度 （28），包括两个或多个通道（22,24,40）的宽度和所有通道间壁（25）组合在一起，所述室（20）在垂直于通道的方向上具有宽度（26） 22,24,40）和在与所述通道平行的方向上的长度（32），所述宽度（26）是所述总通道宽度（28）的至少两倍，所述腔室（20）具有两个相对的主表面（56 ）限定其高度（30），所述腔室（20）的主表面积与体积比至少为10cm 2 / cm 3。 还公开了使用自持式振荡喷射混合室的微流体混合的方法。

    MICROSTRUCTURE DESIGNS FOR OPTIMIZING MIXING AND PRESSURE DROP
    5.
    发明申请
    MICROSTRUCTURE DESIGNS FOR OPTIMIZING MIXING AND PRESSURE DROP 审中-公开
    用于优化混合和压降的微结构设计

    公开(公告)号：WO2005120690A1

    公开(公告)日：2005-12-22

    申请号：PCT/EP2005/006265

    申请日：2005-06-09

    Applicant: CORNING INCORPORATED ,  WOEHL, Pierre ,  THEMONT, Jean-Pierre ,  NEDELEC, Yann

    Inventor： WOEHL, Pierre ,  THEMONT, Jean-Pierre ,  NEDELEC, Yann

    IPC: B01F13/00

    CPC classification number: B01F13/0059 ,  B01F5/0451 ,  B01F5/0453 ,  B01F5/046 ,  B01F5/061 ,  B01F5/0646 ,  B01F2005/0621 ,  B01F2005/0636 ,  Y10S366/03

    Abstract: A class of designs is provided for a mixer in micro reactors where the design principle includes at least one injection zone (410) in a continuous flow path where at least two fluids achieve initial upstream contact and an effective mixing zone (i.e. adequate flow of fluids and optimal pressure drop) containing a series of mixer elements (430) in the path. Each mixer element is preferably designed with a chamber at each end in which an obstacle (450) is placed (thereby reducing the typical inner dimension of the chamber) and with optional restrictions (460) in the channel segments. The obstacles are preferably cylindrical pillars but can have any geometry within a range of dimensions and may be in series or parallel along the flow path to provide the desired flow-rate, mixing and pressure-drop. The injection zone may have two or more interfaces and may, include one or more cores to control fluids before mixing.

    Abstract translation: 提供了一类用于微反应器中的混合器的设计，其中设计原理包括在连续流动路径中的至少一个注入区（410），其中至少两种流体达到初始上游接触和有效混合区（即，足够的流体流动 和最佳压力降），其包含路径中的一系列混合器元件（430）。 每个混合器元件优选地设计成在每个端部设置有腔室，其中放置有障碍物（450）（从而减小了腔室的典型内部尺寸），并且在通道段中具有可选的限制（460）。 障碍物优选地是圆柱形柱，但是在尺寸范围内可以具有任何几何形状，并且可以沿着流动路径串联或平行，以提供期望的流速，混合和压降。 注射区可以具有两个或更多个界面，并且可以包括一个或多个芯以在混合之前控制流体。

    METHODS AND DEVICES FOR FALLING FILM REACTORS WITH INTEGRATED HEAT EXCHANGE
    6.
    发明申请
    METHODS AND DEVICES FOR FALLING FILM REACTORS WITH INTEGRATED HEAT EXCHANGE 审中-公开
    用于整合热交换器的薄膜反应器的方法和装置

    公开(公告)号：WO2009110981A1

    公开(公告)日：2009-09-11

    申请号：PCT/US2009/001233

    申请日：2009-02-27

    Applicant: CORNING INCORPORATED ,  CAZE, Philippe ,  DANNOUX, Thierry L ,  GUERMEUR, Celine C ,  SUTHERLAND, James S ,  WOEHL, Pierre

    Inventor： CAZE, Philippe ,  DANNOUX, Thierry L ,  GUERMEUR, Celine C ,  SUTHERLAND, James S ,  WOEHL, Pierre

    IPC: B01J10/02 ,  B01J10/00 ,  B01J19/24 ,  B01J19/32

    CPC classification number: B01J19/2485 ,  B01J2219/0004 ,  B01J2219/00083 ,  F28D2021/0022 ,  F28F7/02 ,  Y10T137/0318

    Abstract: Disclosed is a method of performing a reaction involving a gaseous reactant stream and a falling film liquid reactant stream by providing a reactor comprising a first multicellular extruded body oriented with its cells extending in parallel in a vertically downward direction from a first end of the body to a second end, the body having a first plurality of cells open at both ends of the body and a second plurality of said cells closed at one or both ends of the body, the second plurality of cells being arranged in one or more groups of contiguous cells and cooperating to define at least in part at least one fluidic passage extending through the body; and further flowing a liquid reactant film down inner surfaces of the first plurality of cells while flowing a gaseous reactant stream up or down the centers of the first plurality of cells while flowing a first heat exchange fluid through the at least one fluidic passage. Various alternative devices for performing the method are also disclosed.

    Abstract translation: 公开了一种通过提供包括第一多细胞挤出体的反应器进行包括气态反应物流和降膜液体反应物流的反应的方法，该第一多细胞挤出体的细胞沿其从身体的第一端沿垂直向下的方向平行延伸， 第二端，所述主体具有在所述主体的两端处开放的第一多个单元，以及在所述主体的一端或两端封闭的第二多个所述单元，所述第二多个单元被布置成一组或多组连续的 并且配合以至少部分地限定延伸穿过身体的至少一个流体通道; 并且在使第一热交换流体流过所述至少一个流体通道的同时使第一多个单元的中心向上或向下流动气态反应物流，同时使液体反应物膜向下流动。 还公开了用于执行该方法的各种替代装置。

    MICROFLUIDIC DEVICES AND METHODS FOR IMMISCIBLE LIQUID-LIQUID REACTIONS
    7.
    发明申请
    MICROFLUIDIC DEVICES AND METHODS FOR IMMISCIBLE LIQUID-LIQUID REACTIONS 审中-公开
    微流体装置和易发生液体液体反应的方法

    公开(公告)号：WO2009009130A1

    公开(公告)日：2009-01-15

    申请号：PCT/US2008/008538

    申请日：2008-07-11

    Applicant: CORNING INCORPORATED ,  CHEVALIER, Berengere ,  HORN, Clemens R ,  MORENA, Maxime ,  WOEHL, Pierre

    Inventor： CHEVALIER, Berengere ,  HORN, Clemens R ,  MORENA, Maxime ,  WOEHL, Pierre

    IPC: B01F5/02 ,  B01F13/00 ,  B01F5/06 ,  B01F13/10 ,  B01J19/00

    CPC classification number: B01F5/02 ,  B01F5/0602 ,  B01F5/0603 ,  B01F5/0647 ,  B01F13/0059 ,  B01F13/0094 ,  B01F13/1013 ,  B01F13/1016 ,  B01F15/06 ,  B01F2215/0431 ,  B01J19/0093 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00984

    Abstract: Methods of contacting two or more immiscible liquids comprising providing a unitary thermally-tempered microstructured fluidic device [10] comprising a reactant passage [26] therein with characteristic cross-sectional diameter [11] in the 0.2 to 15 millimeter range, having, in order along a length thereof, two or more inlets [A, B or A, B1] for entry of reactants, an initial mixer passage portion [38] characterized by having a form or structure that induces a degree of mixing in fluids passing therethrough, an initial dwell time passage portion [40] characterized by having a volume of at least 0.1 milliliter and a generally smooth and continuous form or structure and one or more additional mixer passage portions [44], each additional mixer passage portion followed immediately by a corresponding respective additional dwell time passage portion [46]; and flowing the two or more immiscible fluids through the reactant passage, wherein the two or more immiscible fluids are flowed into the two or more inlets [A, B or A, B1] such that the total flow of the two or more immiscible fluids flows through the initial mixer passage portion [38]. Unitary devices [10] in which the method may be performed are also disclosed.

    Abstract translation: 接触两种或更多种不混溶液体的方法包括提供一体的热回火微结构流体装置[10]，其中包含其中具有0.2-15毫米范围的特征横截面直径[11]的反应物通道[26]，按顺序 两个或更多个进口反应物的入口[A，B或A，B1]，初始混合器通道部分[38]，其特征在于具有在其中通过的流体中引起一定程度的混合的形式或结构， 其特征在于具有至少0.1毫升的体积和大致平滑且连续的形式或结构以及一个或多个附加的混合器通道部分[44]，每个附加的混合器通道部分紧随其后的是相应的相应的 额外的停留时间通道部分[46]; 并且使两种或更多种不混溶的流体流过反应物通道，其中两种或更多种不混溶流体流入两个或更多个入口[A，B或A，B1]，使得两种或多种不混溶流体的总流量流动 通过初始混合器通道部分[38]。 还公开了可以执行该方法的单一装置[10]。

    SYSTEMS AND METHODS FOR SCALE-UP OF CONTINUOUS FLOW REACTORS
    10.
    发明申请
    SYSTEMS AND METHODS FOR SCALE-UP OF CONTINUOUS FLOW REACTORS 审中-公开
    连续流动反应器定标系统及方法

    公开(公告)号：WO2012173848A1

    公开(公告)日：2012-12-20

    申请号：PCT/US2012/041192

    申请日：2012-06-07

    Applicant: CORNING INCORPORATED ,  GUIDAT, Roland ,  LOBET, Olivier ,  WOEHL, Pierre

    Inventor： GUIDAT, Roland ,  LOBET, Olivier ,  WOEHL, Pierre

    IPC: B01J19/00

    CPC classification number: B01J19/0053 ,  B01J19/0093 ,  B01J2219/00015 ,  B01J2219/00824 ,  B01J2219/00831 ,  B01J2219/0086 ,  B01J2219/00873 ,  B01J2219/00995 ,  Y10T29/49

    Abstract: A method is disclosed for the seamless scale-up of a micro reactor process, to transfer lab test to a pilot or production unit, the process comprising the steps of using a wall material for the lab reactor with a thermal conductivity lower than 3 W/m-K, and using a wall material for the production reactor with a thermal conductivity higher than 5 W/m-K. According to one preferred embodiment, the velocity is kept constant, and the height of the channel is determined, in order to keep the volumetric heat transfer properties constant, according to the formula: wherein H G is the overall volumetric heat transfer coefficient in the pilot or production process; A B and C are constants; D h is the hydraulic diameter of the channel in the pilot or production process; λ w is the thermal conductivity of the wall in the pilot or production process; b is the empirically determined power to which the Reynolds number is raised in the equation for the Nusselt criteria (Nu = a-Re b Pr c ) for the type of flow in the pilot or production process; h is the height of the channel in the pilot or production process; and H G0 is the overall volumetric heat transfer coefficient in the lab-scale process.

    Abstract translation: 公开了一种用于微反应器过程的无缝放大以将实验室测试转移到先导或生产单元的方法，该方法包括以下步骤：使用导热率低于3W / mK，并且使用导热率高于5W / mK的生产反应器的壁材料。 根据一个优选实施例，速度保持恒定，并且确定通道的高度，以便保持体积传热性能恒定，其中HG是飞行员中的总体积传热系数，或 生产过程; A B和C是常数; Dh是先导或生产过程中通道的液压直径; ？w是先导或生产过程中壁的导热系数; b是在试点或生产过程中的流量类型的努塞尔标准（Nu = a-RebPrc）的方程中提高雷诺数的经验确定的功率; h是飞行员或生产过程中通道的高度; HG0是实验室规模过程中的总体积传热系数。

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