公开(公告)号：WO2015164769A1

公开(公告)日：2015-10-29

申请号：PCT/US2015/027554

申请日：2015-04-24

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  YAMAMOTO, Masato

发明人： YAMAMOTO, Masato

IPC分类号： C12N15/861

CPC分类号： A61K35/761 ,  C07K14/005 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10321 ,  C12N2710/10322 ,  C12N2710/10332 ,  C12N2710/10345 ,  C12N2710/10351 ,  G01N33/57492

摘要： Described herein is an adenovirus comprising an AB-loop comprising a targeting motif and methods of making and using the adenovirus. The targeting motif of the adenovirus can selectively bind to a tumor cell. The targeting motif of the adenovirus can selectively bind to cell markers and/or cell surface antigens including, for example, CD 133.

摘要翻译： 本文描述的是包含包含靶向基序的AB环的腺病毒，以及制备和使用腺病毒的方法。 腺病毒的靶向基序可以选择性地结合肿瘤细胞。 腺病毒的靶向基序可以选择性地结合细胞标志物和/或细胞表面抗原，包括例如CD133。

公开(公告)号：WO2020247735A1

公开(公告)日：2020-12-10

申请号：PCT/US2020/036300

申请日：2020-06-05

申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA ,  HAJERI, Praveensingh Bheemsingh ,  YAMAMOTO, Masato

发明人： HAJERI, Praveensingh Bheemsingh ,  YAMAMOTO, Masato

IPC分类号： C12Q1/68 ,  C12N15/00 ,  C12N15/74 ,  C12P19/34 ,  C40B40/06 ,  C40B40/08 ,  C40B50/06

摘要： A method for producing a library of biological molecules generally includes providing an engineered polynucleotide vector, amplifying the polynucleotide, and sequencing the library of biological molecules produced. The polynucleotide includes a cloning vector backbone, a recombination site, one or more cloning sites, and a nucleotide sequence template. The nucleotide sequence template includes a coding region, a sequence 5' to the coding region that is complementary to a portion of the vector backbone, and a sequence 3' to the coding region that is complementary to a portion of the vector backbone.