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公开(公告)号：WO2015164769A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027554
申请日：2015-04-24
发明人： YAMAMOTO, Masato
IPC分类号： C12N15/861
CPC分类号： A61K35/761 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10332 , C12N2710/10345 , C12N2710/10351 , G01N33/57492
摘要： Described herein is an adenovirus comprising an AB-loop comprising a targeting motif and methods of making and using the adenovirus. The targeting motif of the adenovirus can selectively bind to a tumor cell. The targeting motif of the adenovirus can selectively bind to cell markers and/or cell surface antigens including, for example, CD 133.
摘要翻译： 本文描述的是包含包含靶向基序的AB环的腺病毒，以及制备和使用腺病毒的方法。 腺病毒的靶向基序可以选择性地结合肿瘤细胞。 腺病毒的靶向基序可以选择性地结合细胞标志物和/或细胞表面抗原，包括例如CD133。
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2.发明申请VIRUSES ASSOCIATED WITH IMMUNODEFICIENCY AND ENTEROPATHY AND METHODS USING SAME 审中-公开与免疫缺陷病毒和肠系膜炎相关的病毒及其使用方法
公开(公告)号：WO2014047261A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060579
申请日：2013-09-19
发明人： BAROUCH, Dan, H. , VIRGIN, Herbert , WANG, David , ZHAO, Guoyan , THACKRAY, Larissa , HANDLEY, Scott , PRESTI, Rachel
CPC分类号： C12Q1/703 , A61K39/00 , C12N7/00 , C12N2710/10321 , C12N2710/20021 , C12N2710/22021 , C12N2720/00021 , C12N2750/14021 , C12N2750/14121 , C12N2770/16021 , C12N2770/32021 , C12N2770/32321 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to previously undescribed viruses that are associated with significant expansion of the virome, immunodeficiency, and enteropathy during lentiviral infection. The invention also provides methods to detect acquired immune deficiency syndrome (AIDS) or AIDS progression in a subject, methods to diagnose immunodeficiency or enteropathy in a subject, and methods to identify a therapeutic agent to treat the same.
摘要翻译： 本发明涉及与慢病毒感染期间病毒，免疫缺陷和肠病的显着扩张相关的先前未描述的病毒。 本发明还提供了检测受试者中获得性免疫缺陷综合征（AIDS）或AIDS进展的方法，以及诊断受试者中的免疫缺陷或肠病的方法，以及鉴定治疗药物的方法。
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3.发明申请SUBFAMILY E SIMIAN ADENOVIRUSES A1302, A1320, A1331 AND A1337 AND USES THEREOF 审中-公开亚型艾美公司A1302，A1320，A1331和A1337及其用途
公开(公告)号：WO2013173702A3
公开(公告)日：2014-03-13
申请号：PCT/US2013041565
申请日：2013-05-17
申请人： UNIV PENNSYLVANIA
发明人： ROY SOUMITRA , WILSON JAMES M
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A61K35/761 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10342 , C12N2710/10343 , C12N2740/16234
摘要： Recombinant vectors comprise simian adenovirus A1302 (SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-A1302, SAdV-A1320, SAdV-A1331, and/or SAdV-A1337 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译： 重组载体包含猿猴腺病毒A1302（SAdV-A1302，SAdV-A1320，SAdV-A1331和/或SAdV-A1337序列和在调控序列控制下的异源基因），表达猿腺病毒SAdV-A1302，SAdV- 还公开了A1320，SAdV-A1331和/或SAdV-A1337基因。提供了使用载体和细胞系的方法。
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4.发明申请ADENOVIRUS SEROTYPE 26 VECTORS, NUCLEIC ACID AND VIRUSES PRODUCED THEREBY 审中-公开ADENOVIRUS SEROTYPE 26载体，生产的核酸和病毒
公开(公告)号：WO2006086284A9
公开(公告)日：2011-12-29
申请号：PCT/US2006004060
申请日：2006-02-07
申请人： MERCK & CO INC , BETT ANDREW J , CASIMIRO DANILO R , SHIVER JOHN W , EMINI EMILIO A , CHASTAIN MICHAEL , KASLOW DAVID C
发明人： BETT ANDREW J , CASIMIRO DANILO R , SHIVER JOHN W , EMINI EMILIO A , CHASTAIN MICHAEL , KASLOW DAVID C
IPC分类号： C12Q1/70
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K2039/5256 , A61K2039/54 , A61K2039/545 , A61K2039/57 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10343 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334
摘要： Adenoviral serotypes differ in their natural tropism. The various serotypes of adenovirus have been found to differ in at least their capsid proteins (e.g., penton-base and hexon proteins), proteins responsible for cell binding (e.g., fiber proteins), and proteins involved in adenovirus replication. This difference in tropism and capsid proteins among serotypes has led to many research efforts aimed at redirecting the adenovirus tropism by modification of the capsid proteins. The present invention bypasses such requirement for capsid protein modification as it presents a recombinant, replication-defective adenovirus of serotype 26, a rare adenoviral serotype, and methods for generating the alternative, recombinant adenovirus. Additionally, means of employing the recombinant adenovirus for delivery and expression of heterologous genes are provided.
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5.发明申请SIMIAN SUBFAMILY C ADENOVIRUSES SADV-40, -31, AND-34 AND USES THEREOF 审中-公开SIMIAN亚型C ADENVVUSUS SADV-40，-31和-34及其用途
公开(公告)号：WO2009105084A8
公开(公告)日：2010-10-07
申请号：PCT/US2008013067
申请日：2008-11-24
发明人： ROY SOUMITRA , WILSON JAMES M , VANDENBERGHE LUC H
IPC分类号： C12N7/00 , C07K14/075
CPC分类号： C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343
摘要： A recombinant vector comprises simian adenovirus SAdV-40, SAdV-31 or SAdV-34 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus SAdV-40, SAdV-31 or SAdV-34 gene(s) is also disclosed. Methods of using the vectors and cell lines are provided.
摘要翻译： 重组载体包含猿猴腺病毒SAdV-40，SAdV-31或SAdV-34序列，以及在调节序列控制下的异源基因。 还公开了表达猿猴腺病毒SAdV-40，SAdV-31或SAdV-34基因的细胞系。 提供了使用载体和细胞系的方法。
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6.发明申请SIMIAN ADENOVIRUS NUCLEIC ACID- AND AMINO ACID-SEQUENCES, VECTORS CONTAINING SAME, AND USES THEREOF 审中-公开SIMIAN ADENOVIRUS核酸和氨基酸序列，含有其的载体及其用途
公开(公告)号：WO2010085984A1
公开(公告)日：2010-08-05
申请号：PCT/EP2009/000672
申请日：2009-02-02
申请人： OKAIROS AG , COLLOCA, Stefano , NICOSIA, Alfredo , CORTESE, Riccardo , AMMENDOLA, Virginia , AMBROSIO, Maria
发明人： COLLOCA, Stefano , NICOSIA, Alfredo , CORTESE, Riccardo , AMMENDOLA, Virginia , AMBROSIO, Maria
IPC分类号： C12N15/861 , A61K39/00 , A61K48/00 , C07K14/075
CPC分类号： C12N15/86 , A61K2039/525 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10322 , C12N2710/10334 , C12N2710/10343 , C12N2740/16134
摘要： The present invention relates to novel adenovirus strains with an improved seroprevalence in human. In one aspect, the present invention relates to isolated polypeptides of adenoviral capsid proteins such as hexon, penton and fiber protein and fragments thereof and polynucleotides encoding the same. Also provided is a vector comprising the isolated polynucleotide according to the invention and adenoviruses comprising the isolated polynucleotides or polypeptides according to the invention and a pharmaceutical composition comprising said vector, adenovirus, polypeptide and/or polynucleotide. The invention also relates to the use of the isolated polynucleotides, the isolated polypeptides, the vector, the adenoviruses and/or the pharmaceutical composition for the therapy or prophylaxis of a disease.
摘要翻译： 本发明涉及具有改善人类血清阳性率的新型腺病毒株。 一方面，本发明涉及腺病毒衣壳蛋白如六邻体，五邻体和纤维蛋白及其片段的分离多肽和编码该多肽的多核苷酸。 还提供了包含根据本发明的分离的多核苷酸和包含根据本发明的分离的多核苷酸或多肽的腺病毒的载体和包含所述载体，腺病毒，多肽和/或多核苷酸的药物组合物。 本发明还涉及分离的多核苷酸，分离的多肽，载体，腺病毒和/或药物组合物用于治疗或预防疾病的用途。
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7.发明申请SIMIAN ADENOVIRUSES SADV-36,-42.1, -42.2, AND -44 AND USES THEREOF 审中-公开SIMIAN ADENOVIRUSES SADV-36，-42.1，-42.2和-44及其用途
公开(公告)号：WO2009136977A3
公开(公告)日：2010-03-11
申请号：PCT/US2009001344
申请日：2009-03-03
发明人： ROY SOUMITRA , WILSON JAMES M , VANDENBERGHE LUC H
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , A61K35/761 , A61K39/145 , A61K2039/5256 , A61K2039/57 , C07K14/005 , C12N15/86 , C12N2710/10321 , C12N2710/10322 , C12N2710/10343 , C12N2710/10371 , C12N2760/16122 , C12N2760/16134 , C12N2760/16171
摘要： A recombinant vector comprises simian adenovirus 36, simian adenovirus 42.1, simian adenovirus 42.2 and/or simian adenovirus 44 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus- 36, -42.1, -42.2 or -44 gene(s) is also described. Methods of using the vectors and cell lines are provided.
摘要翻译： 重组载体包含猿猴腺病毒36，猿猴腺病毒42.1，猿腺病毒42.2和/或猿腺病毒44序列和在调节序列控制下的异源基因。 还描述了表达一种或多种猿猴腺病毒-36，-42.1，-42.2或-44基因的细胞系。 提供了使用载体和细胞系的方法。
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公开(公告)号：WO2006069389A1
公开(公告)日：2006-06-29
申请号：PCT/US2005/047377
申请日：2005-12-22
发明人： SENESAC, Joe
CPC分类号： A01N1/02 , A01N1/0221 , A01N1/0263 , A61K48/0091 , C12N7/00 , C12N15/86 , C12N2710/10321 , C12N2710/10343
摘要： The present invention relates generally to the fields of cell banking and viral production. More particularly, it concerns a method of virus production from host cells using flexible containers.
摘要翻译： 本发明一般涉及细胞库和病毒生产领域。 更具体地，涉及使用柔性容器从宿主细胞产生病毒的方法。
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公开(公告)号：WO2006060314A2
公开(公告)日：2006-06-08
申请号：PCT/US2005/042924
申请日：2005-11-28
发明人： HERMISTON, Terry , JIN, Fang , KRETSCHMER, Peter
IPC分类号： C12N15/861 , C12N15/86 , C12N7/00
CPC分类号： C12N15/86 , A61K35/13 , A61K38/45 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2710/10321 , C12N2710/10343 , C12N2710/10361 , C12N2770/20022 , C12N2800/90 , C12N2830/42 , C12Q1/6897 , C12Q1/701
摘要： The present invention relates to the generation of replication-competent viruses having therapeutic utility. The replication-competent viruses of the invention can express proteins useful in the treatment of disease.
摘要翻译： 本发明涉及具有治疗效用的具有复制能力的病毒的产生。 本发明的复制型病毒可以表达可用于治疗疾病的蛋白质。
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公开(公告)号：WO2005071093A3
公开(公告)日：2006-03-30
申请号：PCT/EP2005000558
申请日：2005-01-18
申请人： ANGELETTI P IST RICHERCHE BIO , CIRILLO AGOSTINO , COLLOCA STEFANO , ERCOLE BRUNO BRUNI , MEOLA ANNALISA , NICOSIA ALFREDO , SPORENO ELISABETTA
发明人： CIRILLO AGOSTINO , COLLOCA STEFANO , ERCOLE BRUNO BRUNI , MEOLA ANNALISA , NICOSIA ALFREDO , SPORENO ELISABETTA
IPC分类号： C07K14/075 , A61K38/00 , A61K39/00 , A61K45/06 , A61K48/00 , C07K14/16 , C07K14/18 , C07K14/705 , C12N7/02 , C12N7/04 , C12N15/86 , C12N15/861
CPC分类号： C12N15/86 , A61K38/00 , A61K45/06 , A61K2039/5256 , C07K14/005 , C07K14/70503 , C12N7/00 , C12N2710/10321 , C12N2710/10343 , C12N2710/10351 , C12N2710/10362 , C12N2740/16134 , C12N2770/24222 , C12N2770/24234 , C12N2810/60
摘要： The present invention provides recombinant replication-defective adenoviral vectors derived from chimpanzee adenoviruses and methods for generating recombinant adenoviruses in human E1-expressing cell lines. The invention also provides compositions and methods suitable for use for the delivery and expression of transgenes encoding immunogens against which a boosted immune response is desired. The invention further provides methods of generating clinical grade vector stocks suitable for use in humans. In a particular embodiment the invention contemplates the use of vectors comprising transgenes which encode tumor associated antigens in vaccines and pharmaceutical compositions for the prevention and treatment of cancer.
摘要翻译： 本发明提供了源自黑猩猩腺病毒的重组复制缺陷型腺病毒载体和用于在人E1表达细胞系中产生重组腺病毒的方法。 本发明还提供了适用于递送和表达编码免疫原的转基因的组合物和方法，其中期望有增强的免疫应答。 本发明还提供了产生适合用于人类的临床级矢量种群的方法。 在一个具体实施方案中，本发明考虑使用包含在疫苗中编码肿瘤相关抗原的转基因和用于预防和治疗癌症的药物组合物的转基因。
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