公开(公告)号：WO2008127532A1

公开(公告)日：2008-10-23

申请号：PCT/US2008/003422

申请日：2008-03-12

Applicant: EMORY UNIVERSITY ,  GEORGIA TECH RESEARCH CORPORATION ,  MURTHY, Niren ,  DAVIS, Michael ,  PULENDRAN, Bali ,  YANG, Stephen, C.

Inventor： MURTHY, Niren ,  DAVIS, Michael ,  PULENDRAN, Bali ,  YANG, Stephen, C.

IPC: A61K47/48 ,  C08G4/00 ,  A61K9/16

CPC classification number: C08L59/00 ,  A61K9/1075 ,  A61K9/1641 ,  A61K9/5153 ,  A61K47/6907 ,  A61K47/6921 ,  C08G4/00

Abstract: The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.

Abstract translation: 本发明提供可生物降解的颗粒（例如，三维颗粒）和胶束，其可用于封装用于递送给受试者的活性剂。 本发明还提供了生产和递送这种颗粒和胶束的方法。 另外，本发明提供包含新型颗粒和胶束的使用的疫苗接种策略。

公开(公告)号：WO2005096789A3

公开(公告)日：2006-12-21

申请号：PCT/US2005012571

申请日：2005-04-12

Applicant: GEORGIA TECH RES INST ,  MURTHY NIREN ,  HAO JIHUA ,  GUINN AMY R ,  YANG STEPHEN C ,  HEFFERMAN MICHAEL J ,  PULENDRAN BALI

Inventor： MURTHY NIREN ,  HAO JIHUA ,  GUINN AMY R ,  YANG STEPHEN C ,  HEFFERMAN MICHAEL J ,  PULENDRAN BALI

IPC: A61B5/055 ,  A61K47/48 ,  A61K49/12 ,  A61K49/14

CPC classification number: A61K49/14 ,  A61K47/60 ,  A61K47/65 ,  A61K49/085 ,  A61K49/126

Abstract: The present invention is directed to detectable compositions and methods for making and using such compositions. Detectable compositions comprise detectable constructs comprising a detectable agent. Due to the actions of a specific bioactivity in vivo or in vitro, the detectable construct is altered in some manner so that the detectable agent is detected. The present invention provides diagnostic imaging agents such as for MRI and optical imaging, which are used for sensitive detection of a specific bioactivity within a tissue. The present invention comprises methods and compositions for biocleavable or biodegradable compositions for carrying and releasing active agents for therapeutic or other medical uses. The methods and compositions of the present invention further comprise micelle compositions. The active agents of the present invention may comprise drugs, vaccines, and imaging agents.

Abstract translation: 本发明涉及用于制备和使用这些组合物的可检测组合物和方法。 可检测组合物包含包含可检测试剂的可检测构建体。 由于在体内或体外具有特异性生物活性的作用，可检测的构建体以某种方式改变，以便检测到可检测的试剂。 本发明提供了用于MRI和光学成像的诊断显像剂，其用于敏感地检测组织内的特异性生物活性。 本发明包括用于携带和释放用于治疗或其它医疗用途的活性剂的可生物可降解或可生物降解的组合物的方法和组合物。 本发明的方法和组合物还包含胶束组合物。 本发明的活性剂可以包括药物，疫苗和成像剂。

公开(公告)号：WO2011031889A1

公开(公告)日：2011-03-17

申请号：PCT/US2010/048307

申请日：2010-09-09

Applicant: WATTMINDER, INC ,  YANG, Stephen C. ,  GETSLA, Robert M.

Inventor： YANG, Stephen C. ,  GETSLA, Robert M.

IPC: H01L31/042

CPC classification number: G01J1/4228 ,  G01J2001/4266 ,  G01S3/781 ,  Y02B10/30

Abstract: Energy converters are monitored to ensure that they are operating at acceptable levels. An expected output is predicted using mathematical modeling and compared to the actual output generated by the energy converter. When the difference is above a predetermined threshold, the level of underperformance, along with other parameters, are used to determine a possible cause of underperformance and actions that can be taken to increase the output to acceptable levels. The cause and actions are transmitted to personnel, who are dispatched to service the underperforming energy converter. By centrally locating the mathematical modeling, monitoring, and dispatching, multiple PV modules can be managed from a remote location. When monitoring photovoltaic modules, an irradiation sensor employs multiple photosensors oriented to detect not only the normal components of sunlight but also directional, diffused components of sunlight, thereby increasing the accuracy of the mathematical modeling.

Abstract translation: 对能量转换器进行监控，以确保其工作在可接受的水平。 使用数学建模预测输出，并与能量转换器产生的实际输出进行比较。 当差异超过预定阈值时，使用不良性能以及其他参数来确定可能导致性能下降的可能原因，并且可以采取措施将输出增加到可接受的水平。 事件和行为传送给人员，他们被派往服务表现不佳的能量转换器。 通过集中定位数学建模，监控和调度，可以从远程位置管理多个PV模块。 当监测光伏模块时，照射传感器采用多个光电传感器，不仅可以检测阳光的正常分量，还可以检测太阳光的方向性，扩散分量，从而提高数学建模的准确性。

公开(公告)号：WO2005096789A2

公开(公告)日：2005-10-20

申请号：PCT/US2005/012571

申请日：2005-04-12

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  MURTHY, Niren ,  HAO, Jihua ,  GUINN, Amy R. ,  YANG, Stephen C. ,  HEFFERMAN, Michael J.

Inventor： MURTHY, Niren ,  HAO, Jihua ,  GUINN, Amy R. ,  YANG, Stephen C. ,  HEFFERMAN, Michael J.

IPC: A61K47/48 ,  A61K49/12 ,  A61K49/14

CPC classification number: A61K49/14 ,  A61K47/60 ,  A61K47/65 ,  A61K49/085 ,  A61K49/126

Abstract: The present invention is directed to detectable compositions and methods for making and using such compositions. Detectable compositions comprise detectable constructs comprising a detectable agent. Due to the actions of a specific bioactivity in vivo or in vitro, the detectable construct is altered in some manner so that the detectable agent is detected. The present invention provides diagnostic imaging agents such as for MRI and optical imaging, which are used for sensitive detection of a specific bioactivity within a tissue. The present invention comprises methods and compositions for biocleavable or biodegradable compositions for carrying and releasing active agents for therapeutic or other medical uses. The methods and compositions of the present invention further comprise micelle compositions. The active agents of the present invention may comprise drugs, vaccines, and imaging agents.

Abstract translation: 本发明涉及用于制备和使用这些组合物的可检测组合物和方法。 可检测组合物包含包含可检测试剂的可检测构建体。 由于在体内或体外具有特异性生物活性的作用，可检测的构建体以某种方式改变，以便检测到可检测的试剂。 本发明提供了用于MRI和光学成像的诊断显像剂，其用于敏感地检测组织内的特异性生物活性。 本发明包括用于携带和释放用于治疗或其它医疗用途的活性剂的可生物可降解或可生物降解的组合物的方法和组合物。 本发明的方法和组合物还包含胶束组合物。 本发明的活性剂可以包括药物，疫苗和成像剂。