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Patent Agency Ranking1.发明申请NANOPARTICLES BASED ON GADOLINIUM COORDINATION POLYMERS AS HIGHLY SENSITIVE T1 MRI CONTRAST AGENTS 审中-公开基于GADOLINIUM协调聚合物的纳米颗粒作为高敏感性T1 MRI对比剂
公开(公告)号：WO2012033531A1
公开(公告)日：2012-03-15
申请号：PCT/US2011/001559
申请日：2011-09-08
Applicant: KENT STATE UNIVERSITY , CASE WESTERN RESERVE UNIVERSITY , HUANG, Songping D. , LI, Yongxiu , BASILION, James P. , HAO, Jihua , FLASK, Christopher
Inventor： HUANG, Songping D. , LI, Yongxiu , BASILION, James P. , HAO, Jihua , FLASK, Christopher
IPC: A61B5/055
Abstract: An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.
Abstract translation: 用于生物系统成像或将药物递送至包括由至少一种钆配位聚合物形成的一种或多种纳米颗粒的生物系统的试剂。
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公开(公告)号：WO2005096789A2
公开(公告)日：2005-10-20
申请号：PCT/US2005/012571
申请日：2005-04-12
Applicant: GEORGIA TECH RESEARCH CORPORATION , MURTHY, Niren , HAO, Jihua , GUINN, Amy R. , YANG, Stephen C. , HEFFERMAN, Michael J.
Inventor： MURTHY, Niren , HAO, Jihua , GUINN, Amy R. , YANG, Stephen C. , HEFFERMAN, Michael J.
CPC classification number: A61K49/14 , A61K47/60 , A61K47/65 , A61K49/085 , A61K49/126
Abstract: The present invention is directed to detectable compositions and methods for making and using such compositions. Detectable compositions comprise detectable constructs comprising a detectable agent. Due to the actions of a specific bioactivity in vivo or in vitro, the detectable construct is altered in some manner so that the detectable agent is detected. The present invention provides diagnostic imaging agents such as for MRI and optical imaging, which are used for sensitive detection of a specific bioactivity within a tissue. The present invention comprises methods and compositions for biocleavable or biodegradable compositions for carrying and releasing active agents for therapeutic or other medical uses. The methods and compositions of the present invention further comprise micelle compositions. The active agents of the present invention may comprise drugs, vaccines, and imaging agents.
Abstract translation: 本发明涉及用于制备和使用这些组合物的可检测组合物和方法。 可检测组合物包含包含可检测试剂的可检测构建体。 由于在体内或体外具有特异性生物活性的作用，可检测的构建体以某种方式改变，以便检测到可检测的试剂。 本发明提供了用于MRI和光学成像的诊断显像剂，其用于敏感地检测组织内的特异性生物活性。 本发明包括用于携带和释放用于治疗或其它医疗用途的活性剂的可生物可降解或可生物降解的组合物的方法和组合物。 本发明的方法和组合物还包含胶束组合物。 本发明的活性剂可以包括药物，疫苗和成像剂。
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公开(公告)号：WO2005096789A3
公开(公告)日：2006-12-21
申请号：PCT/US2005012571
申请日：2005-04-12
Applicant: GEORGIA TECH RES INST , MURTHY NIREN , HAO JIHUA , GUINN AMY R , YANG STEPHEN C , HEFFERMAN MICHAEL J , PULENDRAN BALI
Inventor： MURTHY NIREN , HAO JIHUA , GUINN AMY R , YANG STEPHEN C , HEFFERMAN MICHAEL J , PULENDRAN BALI
CPC classification number: A61K49/14 , A61K47/60 , A61K47/65 , A61K49/085 , A61K49/126
Abstract: The present invention is directed to detectable compositions and methods for making and using such compositions. Detectable compositions comprise detectable constructs comprising a detectable agent. Due to the actions of a specific bioactivity in vivo or in vitro, the detectable construct is altered in some manner so that the detectable agent is detected. The present invention provides diagnostic imaging agents such as for MRI and optical imaging, which are used for sensitive detection of a specific bioactivity within a tissue. The present invention comprises methods and compositions for biocleavable or biodegradable compositions for carrying and releasing active agents for therapeutic or other medical uses. The methods and compositions of the present invention further comprise micelle compositions. The active agents of the present invention may comprise drugs, vaccines, and imaging agents.
Abstract translation: 本发明涉及用于制备和使用这些组合物的可检测组合物和方法。 可检测组合物包含包含可检测试剂的可检测构建体。 由于在体内或体外具有特异性生物活性的作用，可检测的构建体以某种方式改变，以便检测到可检测的试剂。 本发明提供了用于MRI和光学成像的诊断显像剂，其用于敏感地检测组织内的特异性生物活性。 本发明包括用于携带和释放用于治疗或其它医疗用途的活性剂的可生物可降解或可生物降解的组合物的方法和组合物。 本发明的方法和组合物还包含胶束组合物。 本发明的活性剂可以包括药物，疫苗和成像剂。
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4.发明申请
公开(公告)号：WO2006122223A2
公开(公告)日：2006-11-16
申请号：PCT/US2006/018182
申请日：2006-05-10
Applicant: EMORY UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION , UNIVERSITY OF ROCHESTER MEDICAL CENTER , PULENDRAN, Bali , MURTHY, Niren , PIERCE, Robert, H. , HEFFERNAN, Michael, J. , HAO, Jihua , KWISSA, Marcin
Inventor： PULENDRAN, Bali , MURTHY, Niren , PIERCE, Robert, H. , HEFFERNAN, Michael, J. , HAO, Jihua , KWISSA, Marcin
CPC classification number: B82Y5/00 , A61K9/1075 , A61K31/573 , C08G4/00 , C08L59/00
Abstract: The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.
Abstract translation: 本发明提供可生物降解的颗粒（例如，三维颗粒）和胶束，其可用于封装用于递送给受试者的活性剂。 本发明还提供了生产和递送这种颗粒和胶束的方法。 另外，本发明提供包含新型颗粒和胶束的使用的疫苗接种策略。
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公开(公告)号：WO2006122223A3
公开(公告)日：2007-05-18
申请号：PCT/US2006018182
申请日：2006-05-10
Applicant: UNIV EMORY , GEORGIA TECH RES INST , UNIV ROCHESTER MEDICAL CT , PULENDRAN BALI , MURTHY NIREN , PIERCE ROBERT H , HEFFERNAN MICHAEL J , HAO JIHUA , KWISSA MARCIN
Inventor： PULENDRAN BALI , MURTHY NIREN , PIERCE ROBERT H , HEFFERNAN MICHAEL J , HAO JIHUA , KWISSA MARCIN
CPC classification number: B82Y5/00 , A61K9/1075 , A61K31/573 , C08G4/00 , C08L59/00
Abstract: The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present invention further provides methods for producing and delivering such particles and micelles. Additionally, the invention provides vaccination strategies that encompass the use of the novel particles and micelles.
Abstract translation: 本发明提供可生物降解的颗粒（例如，三维颗粒）和胶束，其可用于封装用于递送给受试者的活性剂。 本发明还提供了生产和递送这种颗粒和胶束的方法。 另外，本发明提供包含新型颗粒和胶束的使用的疫苗接种策略。
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