公开(公告)号：WO2011015037A1

公开(公告)日：2011-02-10

申请号：PCT/CN2010/001187

申请日：2010-08-05

Applicant: THE UNIVERSITY OF HONGKONG ,  KAO, Yitsun, Richard ,  YANG, Dan ,  YEUN, Kwokyung

Inventor： KAO, Yitsun, Richard ,  YANG, Dan ,  YEUN, Kwokyung

IPC: C07D413/12 ,  C07D295/00 ,  A61K31/497 ,  A61K31/44 ,  A61K31/42 ,  A61K31/00 ,  A61P31/16 ,  A61P31/12

CPC classification number: C07D261/18 ,  A61K31/42 ,  A61K31/422 ,  A61K31/496

Abstract: Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.

Abstract translation: 本文描述了显示抗病毒活性，特别是针对流感病毒的化合物及其制备和使用方法。 在一个实施方案中，化合物是含有哌嗪和异唑环并任选被一个或多个取代基取代的杂环酰胺。 所述化合物可与一种或多种药学上可接受的赋形剂一起配制以形成适于肠胃外给药的组合物。 该化合物优选用于治疗或预防流感毒素，例如H1N1，H2N2，H3N2，H5N1，H7N7，H1N2，H9N2，H7N2，H7N3和H10N7。