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    METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION
    4.
    发明申请
    METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION 审中-公开
    与基因表达VIVO成像相关的方法和组合

    公开(公告)号：WO2006099019A8

    公开(公告)日：2008-01-24

    申请号：PCT/US2006008374

    申请日：2006-03-09

    Applicant: UNIV TEXAS ,  KUNDRA VIKAS ,  FANG BINGLIANG ,  JI LIN X ,  YANG DAN

    Inventor： KUNDRA VIKAS ,  FANG BINGLIANG ,  JI LIN X ,  YANG DAN

    IPC: C12N15/85 ,  A61K49/00 ,  C07K14/705

    CPC classification number: C12N15/85 ,  A61K49/0002 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/203

    Abstract: Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine.

    Abstract translation: 公开了编码与组织选择性启动子序列可操作偶联的重组七跨膜G蛋白相关受体（GPCR）氨基酸序列的核酸序列。 还公开了在受试者中成像或治疗细胞的方法，其涉及使用与受试者的组织选择性启动子或扩增的组织特异性启动子有效偶联的非侵入性方法引入编码可体内报道物的核酸的核酸， 涉及与感兴趣的报告物或基因选择性相互作用的非侵入性成像技术或治疗剂。 例如，受试者可以是具有癌症的受试者，并且治疗剂可以是抗癌剂。 特别地，hTERT启动子或扩增的hTERT启动子驱动报道分子如hSSTR2和/或hSSTR2衍生物的表达），并且这些可以与感兴趣的基因连接。 成像可以通过包括核医学在内的各种方法进行。

    METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION
    5.
    发明申请
    METHODS AND COMPOSITION RELATED TO IN VIVO IMAGING OF GENE EXPRESSION 审中-公开
    与基因表达VIVO成像相关的方法和组合

    公开(公告)号：WO2006099019A2

    公开(公告)日：2006-09-21

    申请号：PCT/US2006/008374

    申请日：2006-03-09

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  KUNDRA, Vikas ,  FANG, Bingliang ,  JI, Linx, X. ,  YANG, Dan

    Inventor： KUNDRA, Vikas ,  FANG, Bingliang ,  JI, Linx, X. ,  YANG, Dan

    IPC: C12N15/85 ,  C07K14/705 ,  A61K49/00

    CPC classification number: C12N15/85 ,  A61K49/0002 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2830/60 ,  C12N2830/85 ,  C12N2840/203

    Abstract: Disclosed are nucleic acid sequences encoding a recombinant seven transmembrane G-protein associated receptor (GPCR) amino acid sequence operatively coupled to a tissue-selective promoter sequence. Also disclosed are methods of imaging or treating cells in a subject that involve introducing a nucleic acid encoding a reporter detectable in vivo using non-invasive methods operatively coupled to a tissue-selective promoter or amplified tissue specific promoter to the subject, and subjecting the subject to a non-invasive imaging technique or a therapeutic that selectively interacts with the reporter or gene of interest. For example, the subject may be a subject with cancer, and the therapeutic may be an anti-cancer agent. In particular, the hTERT promoter or amplified hTERT promoter drives expression of a reporter such hSSTR2 and/or hSSTR2 derivative) and these may be linked to a gene of interest. Imaging may be performed by a variety of methods including nuclear medicine.

    Abstract translation: 公开了编码与组织选择性启动子序列可操作偶联的重组七跨膜G蛋白相关受体（GPCR）氨基酸序列的核酸序列。 还公开了在受试者中成像或治疗细胞的方法，其涉及使用与受试者的组织选择性启动子或扩增的组织特异性启动子有效偶联的非侵入性方法引入编码可体内报道物的核酸的核酸， 涉及与感兴趣的报告物或基因选择性相互作用的非侵入性成像技术或治疗剂。 例如，受试者可以是具有癌症的受试者，并且治疗剂可以是抗癌剂。 特别地，hTERT启动子或扩增的hTERT启动子驱动报道分子如hSSTR2和/或hSSTR2衍生物的表达），并且这些可以与感兴趣的基因连接。 成像可以通过包括核医学在内的各种方法进行。

    ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THERE OF CROSS REFERENCE TO RELATED APPLICATIONS
    7.
    发明申请
    ANTIVIRAL COMPOUNDS AND METHODS OF MAKING AND USING THERE OF CROSS REFERENCE TO RELATED APPLICATIONS 审中-公开
    抗病毒化合物及其制备方法及其相关应用的交叉参考

    公开(公告)号：WO2011015037A1

    公开(公告)日：2011-02-10

    申请号：PCT/CN2010/001187

    申请日：2010-08-05

    Applicant: THE UNIVERSITY OF HONGKONG ,  KAO, Yitsun, Richard ,  YANG, Dan ,  YEUN, Kwokyung

    Inventor： KAO, Yitsun, Richard ,  YANG, Dan ,  YEUN, Kwokyung

    IPC: C07D413/12 ,  C07D295/00 ,  A61K31/497 ,  A61K31/44 ,  A61K31/42 ,  A61K31/00 ,  A61P31/16 ,  A61P31/12

    CPC classification number: C07D261/18 ,  A61K31/42 ,  A61K31/422 ,  A61K31/496

    Abstract: Compounds which exhibit antiviral activity, particularly against influenza virus,and methods of making and using there of are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteralor parenteral administration. The compounds are preferably used to treat or prevent Influenza Ainfections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.

    Abstract translation: 本文描述了显示抗病毒活性，特别是针对流感病毒的化合物及其制备和使用方法。 在一个实施方案中，化合物是含有哌嗪和异唑环并任选被一个或多个取代基取代的杂环酰胺。 所述化合物可与一种或多种药学上可接受的赋形剂一起配制以形成适于肠胃外给药的组合物。 该化合物优选用于治疗或预防流感毒素，例如H1N1，H2N2，H3N2，H5N1，H7N7，H1N2，H9N2，H7N2，H7N3和H10N7。

    LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES
    8.
    发明申请
    LUMINESCENCE QUENCHERS AND FLUOROGENIC PROBES FOR DETECTION OF REACTIVE SPECIES 审中-公开
    用于检测反应物种的荧光探针和荧光探针

    公开(公告)号：WO2009121247A1

    公开(公告)日：2009-10-08

    申请号：PCT/CN2009/000376

    申请日：2009-04-07

    Applicant: VERSITECH LIMITED ,  MORNINGSIDE VENTURES LIMITED ,  YANG, Dan ,  PENG, Tao

    Inventor： YANG, Dan ,  PENG, Tao

    IPC: C07D493/10 ,  C07D405/00 ,  C07D491/00 ,  C07D405/14 ,  C07D311/82 ,  C07D311/00 ,  G01N21/64 ,  G01N21/77 ,  G01N33/533

    CPC classification number: G01N21/6428 ,  C07D307/94 ,  C07D493/10 ,  G01N33/533

    Abstract: Provided herein are compounds or fluorogenic probes which can be used as reagents for measuring, detecting and/or screening ROS or RNS such as peroxynitrite or hypochlorite. Provided also herein are methods that can be used to measure, directly or indirectly, the amount of peroxynitrite or hypochlorite in chemical samples and biological samples such as cells and tissues in living organisms. Specifically, the methods include the steps of contacting the fluorogenic probes disclosed herein with the samples to form one or more fluorescent compounds, and measuring fluorescence properties of the fluorescent compounds. Provided also herein are high-throughput screening fluorescent methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite or hypochlorite in chemical and biological samples.

    Abstract translation: 本文提供了可用作测量，检测和/或筛选ROS或RNS如过氧亚硝酸盐或次氯酸盐的试剂的化合物或荧光探针。 本文还提供了可用于直接或间接测量化学样品和生物样品中过氧亚硝酸盐或次氯酸盐的量的方法，例如活生物体中的细胞和组织。 具体地，所述方法包括使本文公开的荧光探针与样品接触以形成一种或多种荧光化合物并测量荧光化合物的荧光性质的步骤。 本文还提供了用于检测或筛选过氧亚硝酸盐或化合物的高通量筛选荧光方法，其可以增加或降低化学和生物样品中过氧亚硝酸盐或次氯酸盐的水平。

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