公开(公告)号：WO2006088305A1

公开(公告)日：2006-08-24

申请号：PCT/KR2006/000512

申请日：2006-02-14

申请人： CHONG KUN DANG PHARMACEUTICAL CORP. ,  SHIN, Hee Jong ,  KI, Min Hyo ,  YOON, Bok-young ,  AN, Sung Won

发明人： SHIN, Hee Jong ,  KI, Min Hyo ,  YOON, Bok-young ,  AN, Sung Won

IPC分类号： A61K9/20

CPC分类号： A61K9/0065 ,  A61K9/0007 ,  A61K9/2031

摘要： The present invention relates to a gastric-retentive controlled release mono-matrix tablet composition, comprising: a) at least one pharmacologically active substance; b) hydrogel-forming materials consisting of polyethylene oxide and at least one component selected from poloxamers and colloidal silica; and c) a carbon dioxide-generating material. The composition of the present invention floats in gastric juice and can continuously release the active substance in the stomach at a constant rate for at least 2 hours.

摘要翻译： 本发明涉及一种胃保持性控释单基质片组合物，其包含：a）至少一种药理学活性物质; b）由聚环氧乙烷和至少一种选自泊洛沙姆和胶体二氧化硅的组分组成的水凝胶形成材料; 和c）产生二氧化碳的材料。 本发明的组合物漂浮在胃液中，可以以恒定速率连续释放胃中的活性物质至少2小时。

公开(公告)号：WO2005123138A1

公开(公告)日：2005-12-29

申请号：PCT/KR2005/000666

申请日：2005-03-10

申请人： CHONG KUN DANG PHARMACEUTICAL CORP. ,  LEE, Sang-Joon ,  SHIN, Hee-Jong ,  KI, Min-Hyo ,  YOON, Bok-Young

发明人： LEE, Sang-Joon ,  SHIN, Hee-Jong ,  KI, Min-Hyo ,  YOON, Bok-Young

IPC分类号： A61K47/30

CPC分类号： A61K9/1635 ,  A61K9/1617 ,  A61K9/1652

摘要： The present invention provides a pharmaceutical composition in the form of pellet wherein controlled release of pharmacologically active substances can be effected. The present invention is characterized by a pharmaceutical composition for controlled release pellets, consisting es¬ sentially of: a) one or more pharmacologically active substances; b) one or more lipids having a low-melting point of less than 70°C and existing as a solid at room temperature; c) one or more hydrophilic substances; and d) one or more water-insoluble binding agents, prepared without melting the lipids.

摘要翻译： 本发明提供了丸剂形式的药物组合物，其中可以实现药理活性物质的控制释放。 本发明的特征在于用于控释丸剂的药物组合物，其包括：a）一种或多种药理活性物质; b）一种或多种低熔点小于70℃并在室温下作为固体存在的脂质; c）一种或多种亲水性物质; 和d）一种或多种不溶于脂质的水不溶性结合剂。

公开(公告)号：WO2005123138A9

公开(公告)日：2006-04-06

申请号：PCT/KR2005000666

申请日：2005-03-10

申请人： CHONG KUN DANG PHARM CORP ,  LEE SANG-JOON ,  SHIN HEE-JONG ,  KI MIN-HYO ,  YOON BOK-YOUNG

发明人： LEE SANG-JOON ,  SHIN HEE-JONG ,  KI MIN-HYO ,  YOON BOK-YOUNG

IPC分类号： A61K9/22 ,  A61K9/16 ,  A61K47/30

CPC分类号： A61K9/1635 ,  A61K9/1617 ,  A61K9/1652

摘要： The present invention provides a pharmaceutical composition in the form of pellet wherein controlled release of pharmacologically active substances can be effected. The present invention is characterized by a pharmaceutical composition for controlled release pellets, consisting es¬ sentially of: a) one or more pharmacologically active substances; b) one or more lipids having a low-melting point of less than 70°C and existing as a solid at room temperature; c) one or more hydrophilic substances; and d) one or more water-insoluble binding agents, prepared without melting the lipids.

摘要翻译： 本发明提供了丸剂形式的药物组合物，其中可以实现药理活性物质的控制释放。 本发明的特征在于用于控释丸剂的药物组合物，其包括：a）一种或多种药理活性物质; b）一种或多种低熔点小于70℃并在室温下作为固体存在的脂质; c）一种或多种亲水性物质; 和d）一种或多种不溶于脂质的水不溶性结合剂。