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    METHOD OF TRACKING AND TRACING SYRINGES IN THE PHARMACEUTICAL INDUSTRY
    1.
    发明申请
    METHOD OF TRACKING AND TRACING SYRINGES IN THE PHARMACEUTICAL INDUSTRY 审中-公开
    在制药工业中追踪和追踪注射器的方法

    公开(公告)号：WO2018013177A1

    公开(公告)日：2018-01-18

    申请号：PCT/US2017/017533

    申请日：2017-02-10

    Applicant: ZEBRASCI, INC.

    Inventor： NGUYEN, Hoang, Thanh ,  NOOLANDI, Jaan ,  GERTZ, Frederick, Talley ,  SCHULTHEIS, Robert, James

    IPC: G06K19/06 ,  A61J1/18 ,  A61M5/14 ,  G06Q50/22 ,  G06Q10/08

    Abstract: A tracking and tracing method is provided during the life of the pharmaceutical container to improve the safety and efficacy of the pharmaceutical container and its content. An identification code is added to the surface of the pharmaceutical container, which is not visible under ambient light. The identification code contains encrypted information regarding temporal and physical properties of the pharmaceutical container and pharmaceutical fluid content. At multiple stages during the life of the pharmaceutical container the identification code is detected with an optical detection method. Given the material of the identification code, the identification code is only visible by using specific optical detection methods.

    Abstract translation: 在药物容器的寿命期间提供追踪和跟踪方法，以提高药物容器及其内容的安全性和功效。 识别码被添加到药物容器的表面，这在环境光线下是不可见的。 识别码包含关于药物容器的时间和物理特性以及药物液体内容的加密信息。 在药物容器的使用寿命期间的多个阶段，使用光学检测方法来检测识别码。 鉴于识别码的材料，只有使用特定的光学检测方法才能看到识别码。

    SELF-LUBRICATING MEDICAL SYRINGES
    2.
    发明申请
    SELF-LUBRICATING MEDICAL SYRINGES 审中-公开
    自润滑医用注射器

    公开(公告)号：WO2016205314A1

    公开(公告)日：2016-12-22

    申请号：PCT/US2016/037549

    申请日：2016-06-15

    Applicant: ZEBRASCI, INC.

    Inventor： GERTZ, Frederick, Talley ,  NOOLANDI, Jaan ,  SCHULTHEIS, Robert, James ,  WILCOX, Daniel, Alden

    IPC: A61M5/315

    CPC classification number: A61M5/31513

    Abstract: A self-lubricating medical syringe is provided for self-lubricating the inner surface of a prefilled syringe barrel. The syringe has a plunger distinguishing a compressible porous cylinder, which can be infused with a lubricant and is sandwiched in between a proximal and distal rubber tip. The self-lubricating medical syringe will be able to compensate for any missing lubricant along the inner surface of the syringe barrel and will also be able to provide for a uniform motion of the plunger.

    Abstract translation: 提供自润滑的医疗注射器用于自动润滑预充式注射器筒的内表面。 注射器具有区分可压缩多孔圆筒的柱塞，其可以注入润滑剂并且被夹在近端和远端橡胶尖端之间。 自润滑医疗注射器将能够补偿沿着注射器筒的内表面的任何缺失的润滑剂，并且还能够提供柱塞的均匀运动。

    MICROPATTERNING TECHNIQUE FOR CREATING MORPHOLOGICALLY SPECIFIC FREE-FLOATING STRUCTURES FOR USE AS STANDARDS IN THE PHARMACEUTICAL INDUSTRY
    4.
    发明申请
    MICROPATTERNING TECHNIQUE FOR CREATING MORPHOLOGICALLY SPECIFIC FREE-FLOATING STRUCTURES FOR USE AS STANDARDS IN THE PHARMACEUTICAL INDUSTRY 审中-公开
    用于制造形态特定的自由浮动结构的微型附加技术用作制药行业的标准

    公开(公告)号：WO2017155734A1

    公开(公告)日：2017-09-14

    申请号：PCT/US2017/019829

    申请日：2017-02-28

    Applicant: ZEBRASCI, INC.

    Inventor： GERTZ, Frederick, Talley ,  SCHULTHEIS, Robert, James

    IPC: A61J1/00 ,  G03F7/00 ,  G01N21/90

    Abstract: A method is provided of using morphologically specific free-floating structures as Standards in the pharmaceutical industry to test objects in drug containers. These structures are micropatterned according to a desired pattern. A container is filled with a defined number of the standards, which then can be used as a standard reference for testing other drug products held in a drug container. The testing pertains to optically identifying structures in the drug container that can be similar in size and shape as the standards, or that can be different in size and shape as the standards. The advantage of the method is that imaging systems with tracking algorithms that count and track sub-visible and visible particles in solution can be used to identify e.g. glass flakes and other foreign particles by comparing them to the shape and size of the standard reference particles.

    Abstract translation: 提供了一种在制药工业中使用形态学上特定的自由浮动结构作为标准来测试药物容器中的物体的方法。 这些结构根据所需的图案进行微图案化。 一个容器装满了一定数量的标准，然后可以将其用作测试容器中其他药品的标准参考。 测试涉及光学识别药物容器中的结构，其可以与标准尺寸和形状相似，或者可以与标准尺寸和形状不同。 该方法的优点是具有跟踪算法的成像系统可以计算和跟踪溶液中的亚可见和可见颗粒，可以用来识别例如 玻璃薄片和其他外来颗粒，通过与标准参考颗粒的形状和大小进行比较。

    HIGH DEFINITION PARTICLE DETECTION DURING CENTRIFUGATION
    5.
    发明申请
    HIGH DEFINITION PARTICLE DETECTION DURING CENTRIFUGATION 审中-公开
    离心时的高清颗粒检测

    公开(公告)号：WO2017095755A1

    公开(公告)日：2017-06-08

    申请号：PCT/US2016/063881

    申请日：2016-11-28

    Applicant: ZEBRASCI, INC.

    Inventor： NGUYEN, Hoang, Thanh ,  NOOLANDI, Jaan ,  SCHULTHEIS, Robert, James

    IPC: B01L3/02 ,  B01D45/00 ,  G01N35/00

    CPC classification number: G02B21/0016 ,  B04B13/00 ,  B04B2013/006 ,  G01N33/15 ,  G02B21/06 ,  G02B21/361 ,  G02B21/362 ,  G02B21/365 ,  G02B21/367

    Abstract: High-definition particle detection during centrifugation of a pharmaceutical liquid is provided. Centrifugation of fluid containers drives particles to the interior surface of the container if the particles are denser than the fluid and to the middle of the container if the particles are less dense than the fluid. The imager can then be focused directly on the particle itself for rapid identification without the need for computing complex particle trajectories. If the centrifugation of the container is carried out at an angle to the axis of symmetry of the container, particles can be driven to a single line on the interior surface of the container by the centrifugal force, making the identification of the particles even more straightforward than in two dimensions. The particle imager can also be attached to the rotating container to prevent blurring of the particle image due to the relative motion of the container and imager.

    Abstract translation: 提供药物离心期间的高分辨率颗粒检测。 如果颗粒比流体更密集，并且如果颗粒比流体密度小，则流体容器的离心将颗粒驱动到容器的内表面，如果颗粒比流体更密集并且容器的中间。 然后，成像仪可以直接聚焦在粒子本身上进行快速识别，而无需计算复杂的粒子轨迹。 如果容器的离心与容器对称轴成一定角度进行，则颗粒可以通过离心力被驱动到容器内表面上的一条线上，使得颗粒的识别更加直接 比二维。 颗粒成像仪也可以连接到旋转容器上，以防止由于容器和成像仪的相对运动造成的颗粒图像模糊。

    SYRINGE BARREL LUBRICANT COVERAGE QUALITY CONTROL
    7.
    发明申请
    SYRINGE BARREL LUBRICANT COVERAGE QUALITY CONTROL 审中-公开
    SYRINGE BARREL润滑剂覆盖质量控制

    公开(公告)号：WO2016057068A1

    公开(公告)日：2016-04-14

    申请号：PCT/US2015/017825

    申请日：2015-02-26

    Applicant: ZEBRASCI, INC.

    Inventor： DENINA, Giovanni, Laviste ,  NGUYEN, Hoang, Thanh ,  SCHULTHEIS, Robert, James ,  GERTZ, Frederick, Talley

    IPC: G01N21/00

    CPC classification number: A61M5/3129 ,  A61M2005/3131 ,  G01N21/954 ,  G01N2021/9548

    Abstract: A quality control method or system for determining a lubricant coverage at the inside surface of a syringe barrel is provided. The timing for the quality control is not intuitive, yet crucial for patient's safety. The pre-fill test is for a pre-filled (empty or no drug solution), yet oil lubricated, barrel. This pre-fill test needs to be performed within a certain time window immediately following the lubrication. The post-fill test is for a post-filled oil lubricated syringe barrel filled with a solution. This post-fill test needs to be performed after a certain time window has passed from the filling with the solution. The quality control methods could lead to a reduction of health-risks or avoid life- threatening situations associated with syringes that are either below or above the desired lubrication coverage.

    Abstract translation: 提供了一种用于确定注射器筒内表面上的润滑剂覆盖度的质量控制方法或系统。 质量控制的时机不直观，对患者的安全至关重要。 预填充测试用于预填充（空或不用药物溶液），但是油润滑，桶。 该预填充测试需要在润滑后立即在一定时间窗内进行。 填充后测试用于填充溶液的后填充油润滑的注射器筒。 这个填充后测试需要在从解决方案的填充过去一定时间窗口之后进行。 质量控制方法可能导致降低健康风险，或避免与低于或高于所需润滑覆盖率的注射器相关的危及生命的情况。

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