公开(公告)号：WO2015138514A1

公开(公告)日：2015-09-17

申请号：PCT/US2015/019796

申请日：2015-03-10

Applicant: 3-D MATRIX, LTD.

Inventor： GIL, Eun Seok ,  GILBERT, Karl ,  MEHTA, Manav

IPC: C07K7/08 ,  A61L27/22 ,  A61K38/12 ,  A61L27/54 ,  A61L27/58

CPC classification number: C07K7/08 ,  A61K38/00 ,  A61L24/108 ,  A61L27/227

Abstract: The present disclosure provides peptide compositions (e.g., of self-assembling peptides) with particular attributes (e.g., peptide identity, peptide concentration, pH, ionic strength [including salt identity and/or concentration), etc that show particularly useful material properties. The present disclosure also provides technologies for selecting and/or formulating particular peptide compositions useful in specific contexts. In some embodiments, provided peptide compositions have an elevated pH within the range of about 2.5 to about 3.5 and/or an ionic strength that is above that of a corresponding composition of the same peptide, at the same concentration, in water, but is below a critical salt point for the peptide (e.g., so that the composition is not cloudy).

Abstract translation: 本公开提供具有特别有用的材料性质的特定属性（例如肽同一性，肽浓度，pH，离子强度（包括盐同一性和/或浓度）等）的肽组合物（例如自组装肽）。 本公开还提供了用于选择和/或配制在特定上下文中有用的特定肽组合物的技术。 在一些实施方案中，所提供的肽组合物具有在约2.5至约3.5范围内的升高的pH值和/或高于相同肽在相同浓度的水中的相应组合物的离子强度，但低于 肽的临界盐点（例如，使得组合物不浑浊）。