公开(公告)号：WO2021202577A1

公开(公告)日：2021-10-07

申请号：PCT/US2021/024954

申请日：2021-03-30

Applicant: 3-D MATRIX, LTD.

Inventor： RIOULT, Marika, G. ,  GIL, Eun Seok ,  ALEKSI, Elton ,  YAMAMOTO, Naoki

IPC: A61K38/16 ,  A61K38/00 ,  A61L27/52 ,  A61L27/50 ,  A61L2/0035 ,  A61L2/081 ,  A61L2/26 ,  A61L27/227 ,  C07K7/08 ,  C12N5/0068

Abstract: Gamma ray and e-beam irradiation provided efficient sterilization of certain self- assembling peptides (including RADA16 in solution) without substantial degradation of the major peptide, while, e.g., another self-assembly peptide, QLEL12 was significantly degraded following irradiation. Irradiation sterilization enhances the rheological property of, for example, RADA16 hydrogel once applied to tissue at a physiological pH. The rheological property increase can result in higher efficacy in a variety of biomedical applications.