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    IDENTIFICATION AND TREATMENT OF TUMORS CHARACTERIZED BY AN OVEREXPRESSION OF THE NEONATAL FC RECEPTOR
    1.
    发明申请
    IDENTIFICATION AND TREATMENT OF TUMORS CHARACTERIZED BY AN OVEREXPRESSION OF THE NEONATAL FC RECEPTOR 审中-公开
    新生儿FC受体表达过度表达的肿瘤的鉴定和治疗

    公开(公告)号：WO2018082758A1

    公开(公告)日：2018-05-11

    申请号：PCT/DK2017/050363

    申请日：2017-11-03

    申请人： AARHUS UNIVERSITET ,  ALBUMEDIX A/S

    发明人： HOWARD, Kenneth Alan ,  CAMERON, Jason ,  LARSEN, Maja Thim ,  DAGNÆS-HANSEN, Frederik

    IPC分类号： G01N33/574 ,  G01N33/566 ,  A61K47/64

    摘要： In a first aspect, the invention relates to the identification of cancer types over- expressing the FcRn receptor. In a second aspect, the invention relates to the treatment of said cancer types.In further aspects,the invention relates to identification of subtypes of inflammatory diseases and treatments thereof.In an additional aspect, the invention relates to in vivo imaging of cancers over- expressing the FcRn receptor.

    摘要翻译： 在第一方面，本发明涉及鉴定过表达FcRn受体的癌症类型。 第二方面，本发明涉及所述癌症类型的治疗。在另外的方面，本发明涉及鉴定炎性疾病的亚型及其治疗。在另外的方面，本发明涉及癌症过表达的体内成像， 表达FcRn受体。

    MODIFIED PAYLOAD MOLECULES AND THEIR INTERACTIONS AND USES
    2.
    发明申请
    MODIFIED PAYLOAD MOLECULES AND THEIR INTERACTIONS AND USES 审中-公开
    改性PAYLOAD分子及其相互作用和用途

    公开(公告)号：WO2014005596A1

    公开(公告)日：2014-01-09

    申请号：PCT/DK2013/050223

    申请日：2013-07-03

    申请人： AARHUS UNIVERSITET

    发明人： HOWARD, Kenneth Alan ,  BIENK, Konrad ,  KRAGH-HANSEN, Ulrich

    IPC分类号： C12N15/11 ,  C07K14/765 ,  A61K31/7088 ,  A61K47/48

    CPC分类号： C12N15/111 ,  A61K47/54 ,  A61K47/60 ,  A61K47/643 ,  C12N2310/14 ,  C12N2310/3231 ,  C12N2310/3515 ,  C12N2320/32

    摘要： An object of the present invention relates to a composition comprising a payload molecule such as a small interfering nucleic acid (siNA) and albumin or fragments thereof, or fusion polypeptides comprising variant albumin or fragments thereof, of a parent albumin. Another object of the present invention relates to a payload molecule such as a siNA conjugated with one or more cholesteryl and/or one or more fatty acid. A further object of the present invention relates to a payload molecule such as a siNA the composition of the present invention for use as a medicament. Yet another object of the present invention relates topayload molecule such as asiNA or the composition of the present invention for use as in regulating a genetic expression of a transcript or protein associated with a disease.

    摘要翻译： 本发明的目的涉及包含母体白蛋白的有效载荷分子例如小干扰核酸（siNA）和白蛋白或其片段或包含变体白蛋白或其片段的融合多肽的组合物。 本发明的另一个目的涉及一种有效载荷分子，例如与一种或多种胆固醇和/或一种或多种脂肪酸缀合的siNA。 本发明的另一个目的是涉及用作药物的本发明组合物的有效载荷分子例如siNA。 本发明的另一个目的是涉及分子量分析例如asiNA或本发明的组合物，其用于调节与疾病相关的转录物或蛋白质的遗传表达。

    DEHYDRATED CHITOSAN NANOPARTICLES
    5.
    发明申请
    DEHYDRATED CHITOSAN NANOPARTICLES 审中-公开
    脱氢壳聚糖纳米颗粒

    公开(公告)号：WO2009006905A1

    公开(公告)日：2009-01-15

    申请号：PCT/DK2008/050171

    申请日：2008-07-04

    申请人： AARHUS UNIVERSITET ,  KJEMS, Jørgen ,  HOWARD, Kenneth Alan ,  BESENBACHER, Flemming ,  ANDERSEN, Morten Østergaard

    发明人： KJEMS, Jørgen ,  HOWARD, Kenneth Alan ,  BESENBACHER, Flemming ,  ANDERSEN, Morten Østergaard

    IPC分类号： C12N15/11 ,  A61K48/00

    CPC分类号： A61K48/0041 ,  A61K9/5161 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/51

    摘要： The present invention relates to dehydrated nanoparticles comprising chitosan and a nucleic acid. Preferably, the nucleic acid is a siRNA. Dehydrated nanoparticles of the invention have improved storage characteristics. The particles may be used in screening methods, e.g. where they have been dried onto a solid support, such as the surface of a culture well. The nanoparticles may also be dried onto implants for tissue engineering scaffolds, where they enable transfection of cells growing on the scaffold. Moreover, the particles have therapeutic relevance.

    摘要翻译： 本发明涉及包含壳聚糖和核酸的脱水纳米粒子。 优选地，核酸是siRNA。 本发明的脱水纳米颗粒具有改进的储存特性。 颗粒可用于筛选方法，例如， 它们已经被干燥到固体支持物上，例如培养物的表面。 纳米颗粒也可以干燥到用于组织工程支架的植入物上，其中它们能够转染在支架上生长的细胞。 此外，颗粒具有治疗相关性。