公开(公告)号：WO2021133903A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/066826

申请日：2020-12-23

Applicant: ABBOTT DIABETES CARE INC.

Inventor： LATOUR, John, V. ,  MCCANLESS, Jonathan, D. ,  OJA, Stephen ,  OUYANG, Tianmei ,  WALLIS, Kevin, Paul ,  FELDMAN, Benjamin, J. ,  HOSS, Udo ,  QIAN, Suyue

IPC: G01N27/327 ,  A61B5/145 ,  G01N33/66 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3272 ,  G01N27/3277 ,  G01N27/3278

Abstract: Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of (I) wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.

公开(公告)号：WO2022139876A1

公开(公告)日：2022-06-30

申请号：PCT/US2021/037322

申请日：2021-06-15

Applicant: ABBOTT DIABETES CARE INC.

Inventor： HOSS, Udo ,  OUYANG, Tianmei ,  FELDMAN, Benjamin, J. ,  QIAN, Suyue

IPC: A61B5/1486 ,  A61B5/1468 ,  G01N33/487

Abstract: Analyte sensor comprises an electrode layer having an elongate body comprising a proximal end and a distal end. The electrode layer includes a first active working electrode area, a second electrode portion, and at least one gap electrically separating the first active working electrode portion and the second electrode portion. The first active working electrode area comprises at least one sensing spot with at least one analyte responsive enzyme disposed thereupon. Additional analyte sensors disclosed.

公开(公告)号：WO2012078908A1

公开(公告)日：2012-06-14

申请号：PCT/US2011/064000

申请日：2011-12-08

Applicant: ABBOTT DIABETES CARE INC. ,  HOSS, Udo ,  LE, Phu ,  WANG, Yi ,  FUJIMOTO, Frank David ,  QIAN, Suyue ,  TRAN, Lam

Inventor： HOSS, Udo ,  LE, Phu ,  WANG, Yi ,  FUJIMOTO, Frank David ,  QIAN, Suyue ,  TRAN, Lam

IPC: C12Q1/00

CPC classification number: A61B5/14532 ,  A61B5/1473 ,  C12Q1/001 ,  C12Q1/006

Abstract: Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.

Abstract translation: 本公开的实施例涉及具有感测表面的分析物确定方法和装置（例如，电化学分析物监测系统），该感测表面包括彼此横向设置的两个或更多个感测元件，其中感测表面位于体内的工作电极 和/或体外分析物传感器，例如使用分析物传感器和/或测试条的连续和/或自动体内监测。 还提供了在分析物监测中使用例如电化学分析物传感器的系统和方法。