ANALYTE SENSORS FEATURING ONE OR MORE DETECTION-FACILITATING ENHANCEMENTS

    公开(公告)号:WO2021252124A2

    公开(公告)日:2021-12-16

    申请号:PCT/US2021/032180

    申请日:2021-05-13

    摘要: Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors configured to monitor multiple analytes are also in development. Sufficient sensitivity for low-abundance analytes and multiple analytes having differing membrane permeability values may complicate analyte detection in some cases. Analyte sensors may feature enhancements to address one or both of these issues. Some analyte sensors may comprise a carbon working electrode comprising a dielectric substrate, one or more apertures extending through the dielectric substrate and filled with a carbon conductor pillar, a carbon conductor coating on a first face of the dielectric substrate in direct contact with each carbon conductor pillar, and one or more active areas on a second face of the dielectric substrate in electrical communication with the carbon conductor pillars. Photopolymerized mass transport limiting membranes may be used in combination with such carbon working electrodes or with other working electrode types.

    METHOD AND SYSTEM OF PRODUCING A PLURALITY OF ANALYTICAL TEST STRIPS

    公开(公告)号:WO2021123178A1

    公开(公告)日:2021-06-24

    申请号:PCT/EP2020/087036

    申请日:2020-12-18

    摘要: A method of producing a plurality of analytical test strips (146) by using a reel-to-reel process is disclosed. Each analytical test strip (146) comprises at least one first layer (198) having at least one first electrode (200), at least one spacer layer (202) and at least one second layer (204) having at least one second electrode (206). The method comprises: i. providing at least one continuous first layer web (114), having disposed on a first side (118) at least one first electrode layer (120), the first layer web (114) having a first layer edge (122); ii. continuously disposing, in at least one first lamination station (116), at least one continuous spacer layer web (124) onto the first side (118) of the first layer web (114), wherein the spacer layer web (124) has a spacer layer edge (126), wherein the disposing is position-controlled in a master-slave fashion by using a position of the first layer edge (122) as a master position and a position of the spacer layer edge (126) as a slave position, wherein the disposing takes place such that the spacer layer edge (126) is offset from the first layer edge (122) and that, thereby, a portion of the first side (118) of the first layer (114) and a portion of the first electrode layer (120) remain uncovered by the spacer layer web (124); and iii. continuously disposing, in at least one second lamination station (128), at least one continuous second layer web (130) onto the spacer layer web (124), the second layer web (130) having disposed on a first side (132) at least one second electrode layer (134), wherein the disposing is performed such that the second electrode layer (134) faces the first layer web (114), wherein the second layer web (130) has a second layer edge (136), wherein the disposing takes place such that the second layer edge (136) is aligned with the first layer edge (122), and wherein the disposing is position- controlled in a master-slave fashion by using a position of the second layer edge (136) as a slave position. Further disclosed are a cutting station (172) and a manufacturing system (110) for producing a plurality of analytical test strips (146) by using a reel-to-reel process.