公开(公告)号：WO2022147496A1

公开(公告)日：2022-07-07

申请号：PCT/US2022/011026

申请日：2022-01-03

Applicant: ABBOTT DIABETES CARE INC.

Inventor： LE, Phu ,  LATOUR, John, V. ,  WALLIS, Kevin, P. ,  HOSS, Udo

IPC: C12Q1/00

Abstract: The present disclosure provides redox mediators having two tridentate ligands and analyte sensors comprising such redox mediators. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject.

公开(公告)号：WO2019035073A3

公开(公告)日：2019-02-21

申请号：PCT/IB2018/056223

申请日：2018-08-17

Applicant: ABBOTT DIABETES CARE INC.

Inventor： SCOTT, Steven ,  BENNELL, Christopher J. ,  BHOGAL, Claire ,  CRANFIELD, Katie A. ,  TAUB, Marc B. ,  WINTER, Bree M. ,  REYNOLDS, Owen D. ,  BABKA, Jean-Pierre ,  PATEL, Dharmendra S. ,  THOMAS, Christopher A. ,  HOSS, Udo ,  YAHNKE, Mark S. ,  KAHN, Tahir S.

IPC: A61B5/145 ,  A61B5/1495

Abstract: Systems, devices, kits, and methods are provided herein in the form of example embodiments that relate to calibration of medical devices. The medical devices can be sensors adapted to sense a biochemical attribute. The embodiments can be used to determine calibration information specific to an individual medical device. The embodiments can determine the calibration information by reference to one or more parameters obtained during manufacturing of the medical device. The embodiments can also determine the calibration information by reference to in vitro testing of the medical devices. The embodiments also apply to systems incorporating those medical devices in their use in the field. Also described are embodiments of modifications to surfaces of sensor substrates, such as through applied radiation and/or the creation of a well, to aid in the placement and/or sizing of a sensor element on the substrate.

公开(公告)号：WO2019018838A1

公开(公告)日：2019-01-24

申请号：PCT/US2018/043240

申请日：2018-07-23

Applicant: ABBOTT DIABETES CARE INC.

Inventor： HOSS, Udo

IPC: A61B5/145 ,  A61K9/48 ,  A61K9/50 ,  A61K9/51 ,  A61M5/00

Abstract: The disclosed technology provides delivery devices for therapeutic agents, where the delivery devices are configured to be worn on a patient's body, and where the delivery devices deliver a solid formulation of a therapeutic agent subcutaneously to the patient. The delivery devices may in one embodiment be part of an integrated system comprising both a solid formulation delivery device and an analyte sensing device.

公开(公告)号：WO2013086007A2

公开(公告)日：2013-06-13

申请号：PCT/US2012/067965

申请日：2012-12-05

Applicant: ABBOTT DIABETES CARE INC.

Inventor： HOSS, Udo ,  HELLER, Adam

IPC: G01N27/30

CPC classification number: A61B5/1468 ,  A61B5/14532 ,  G01N27/3272

Abstract: The disclosure provides method and materials for preparing biosensors (e.g., in vitro test strips and in vivo sensors) with improved mechanical properties. In some aspects, for example, the electrochemical sensors have improved durability and are better able to withstand mechanical and electrochemical stresses such as those encountered during manufacturing, transportation, storage, and use (e.g., in vivo positioning, in vivo operation, or in vitro operation). Also for example, in some aspects the electrochemical sensors are less susceptible to pinholes and other manufacturing defects that degrade performance in traditional sensors.

Abstract translation: 本公开提供了用于制备具有改进的机械性能的生物传感器（例如，体外测试条和体内传感器）的方法和材料。 在一些方面，例如，电化学传感器具有改善的耐久性，并且能够更好地承受诸如在制造，运输，储存和使用期间遇到的机械和电化学应力（例如，体内定位，体内操作或体外 操作）。 同样例如，在一些方面，电化学传感器较不易受针孔和其他制造缺陷的影响，这些缺陷降低了传统传感器的性能。

公开(公告)号：WO2011130545A1

公开(公告)日：2011-10-20

申请号：PCT/US2011/032542

申请日：2011-04-14

Applicant: ABBOTT DIABETES CARE INC. ,  HOSS, Udo ,  FELDMAN, Benjamin, J. ,  LIU, Zenghe ,  CHO, Hyun ,  RUSH, Benjamin, M.

Inventor： HOSS, Udo ,  FELDMAN, Benjamin, J. ,  LIU, Zenghe ,  CHO, Hyun ,  RUSH, Benjamin, M.

IPC: A61B5/00

CPC classification number: A61B5/1473 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1468 ,  A61B5/7275 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B2560/0252 ,  A61B2560/0443

Abstract: Method and system for determining real time analyte concentration including an analyte sensor having a portion in fluid contact with an interstitial fluid under a skin layer, an on-body electronics including a housing coupled to the analyte sensor and configured for positioning on the skin layer, the on-body electronics housing including a plurality of electrical contacts, on the housing; and a data analysis unit having a data analysis unit housing and a plurality of probes, on the housing. Each of the probes configured to electrically couple to a respective electrical contact when the data analysis unit is positioned in physical contact with the on-body electronics. The one or more signals on the probes correspond to one or more of a substantially real time monitored analyte concentration level (MACL), MACL over a predetermined time period, or a rate of change of the MACL, or combinations thereof, are provided.

Abstract translation: 用于确定实时分析物浓度的方法和系统，包括分析物传感器，所述分析物传感器具有与皮肤层下面的间质液体流体接触的部分;体内电子器件，包括耦合到分析物传感器并被配置用于定位在皮肤层上的壳体， 在壳体上包括多个电触头的体内电子壳体; 以及数据分析单元，其具有在壳体上的数据分析单元壳体和多个探针。 每个探针被配置为当数据分析单元与体内电子器件物理接触地定位时电耦合到相应的电接触。 探针上的一个或多个信号对应于基本上实时监测的分析物浓度水平（MACL），预定时间段内的MACL或MACL的变化率或其组合中的一个或多个。

公开(公告)号：WO2011011643A1

公开(公告)日：2011-01-27

申请号：PCT/US2010/042974

申请日：2010-07-22

Applicant: ABBOTT DIABETES CARE INC. ,  HOSS, Udo ,  MAZZA, John, Charles ,  LE, Phu

Inventor： HOSS, Udo ,  MAZZA, John, Charles ,  LE, Phu

IPC: A61B5/1468

CPC classification number: A61B5/14532 ,  A61B5/002 ,  A61B5/14865 ,  A61B2562/227

Abstract: Low profile continuous analyte measurement systems and systems and methods for implantation within the skin of a patient are provided.

Abstract translation: 提供了用于植入患者皮肤内的低分子连续分析物测量系统和系统和方法。

公开(公告)号：WO2009124095A1

公开(公告)日：2009-10-08

申请号：PCT/US2009/039044

申请日：2009-03-31

Applicant: ABBOTT DIABETES CARE INC. ,  FELDMAN, Benjamin, J. ,  HOSS, Udo ,  CHO, Hyun

Inventor： FELDMAN, Benjamin, J. ,  HOSS, Udo ,  CHO, Hyun

IPC: G01F1/64

CPC classification number: A61B5/14865 ,  A61B5/002 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1495 ,  A61B5/685 ,  A61B5/746 ,  A61B2560/0223 ,  A61B2560/0252 ,  A61B2562/0295

Abstract: Methods and devices to detect analyte in body fluid are provided Embodiment include analyte sensors designed so that at least a portion of the sensor is positionable beneath the skin One or more working electrodes may be placed intradermal^ under the skin layer A detected signal from the implanted portion of the analyte sensor is associated with an analyte level of the user.

Abstract translation: 用于检测体液中分析物的方法和装置实施例包括分析物传感器，其被设计成使得传感器的至少一部分可定位在皮肤下面。一个或多个工作电极可以被皮内层下皮内放置。来自植入物的检测信号 分析物传感器的一部分与用户的分析物水平相关联。

公开(公告)号：WO2022147512A1

公开(公告)日：2022-07-07

申请号：PCT/US2022/011058

申请日：2022-01-03

Applicant: ABBOTT DIABETES CARE INC.

Inventor： CLARY, Jacob ,  LATOUR, John, V. ,  HOSS, Udo ,  OU, Junli ,  CANNADY, Nolan, R.

IPC: A61B5/145 ,  A61B5/1486 ,  A61M5/14

Abstract: The present disclosure provides therapeutic compositions and methods for delivering a therapeutic agent in close proximity to an analyte sensor. In certain embodiments, the present disclosure provides analyte sensors including one or more therapeutic agents, e.g, covalently-bound therapeutic agents. In certain embodiments, the present disclosure further provides therapeutic releasing compositions and methods of delivering such therapeutic releasing compositions.

公开(公告)号：WO2022010620A1

公开(公告)日：2022-01-13

申请号：PCT/US2021/037307

申请日：2021-06-15

Applicant: ABBOTT DIABETES CARE INC.

Inventor： OJA, Stephen ,  FOX, Cade, Brylee ,  TRAN, Lam, N. ,  LIU, Zenghe ,  FELDMAN, Benjamin, J. ,  HOSS, Udo ,  YAHNKE, Mark, Stephen ,  KHAN, Tahir, S. ,  BABKA, Jean-Pierre ,  REYNOLDS, Owen, Daniel

IPC: A61B5/1486 ,  A61B5/1468 ,  G01N33/487 ,  A61B5/14532 ,  A61B5/14865

Abstract: Analyte sensors are being increasingly employed for monitoring various analytes in vivo. Analyte sensors may feature enhancements to address signals obtained from interferent species. Some analyte sensors may comprise a working electrode comprising an active area disposed thereon and electrode asperities laser planed therefrom. Some analyte sensors may comprise an interferent-reactant species incorporated therewith. Some analyte sensors may comprise an interferent scrubbing electrode. Combinations of these enhancements may additionally be employed.

公开(公告)号：WO2021133903A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/066826

申请日：2020-12-23

Applicant: ABBOTT DIABETES CARE INC.

Inventor： LATOUR, John, V. ,  MCCANLESS, Jonathan, D. ,  OJA, Stephen ,  OUYANG, Tianmei ,  WALLIS, Kevin, Paul ,  FELDMAN, Benjamin, J. ,  HOSS, Udo ,  QIAN, Suyue

IPC: G01N27/327 ,  A61B5/145 ,  G01N33/66 ,  A61B5/14532 ,  A61B5/14865 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3272 ,  G01N27/3277 ,  G01N27/3278

Abstract: Analyte sensors responsive at low working electrode potentials may comprise an active area upon a surface of a working electrode, wherein the active area comprises a polymer, a redox mediator covalently bonded to the polymer, and at least one analyte-responsive enzyme covalently bonded to the polymer. A specific redox mediator responsive at low potential may have a structure of (I) wherein G is a linking group covalently bonding the redox mediator to the polymer. A mass transport limiting membrane permeable to the analyte may overcoat the active area. In some sensor configurations, the mass transport limiting membrane may comprise a membrane polymer crosslinked with a branched crosslinker comprising three or more crosslinkable groups, such as polyethylene glycol tetraglycidyl ether.