公开(公告)号：WO2009155324A3

公开(公告)日：2010-02-18

申请号：PCT/US2009047623

申请日：2009-06-17

Applicant: ABBOTT LAB ,  BROPHY SUSAN E ,  CHI LIANLI ,  DATWYLER SAUL A ,  HAWKSWORTH DAVID J ,  LAIRD DON M ,  MANOJ SHARMILA ,  PINKUS MARY S ,  PUCCI DOMINICK L ,  RAMSAY CAROL S ,  SOGIN DAVID C ,  TU BAILIN ,  TYNER JOAN D ,  YU ZHIGUANG ,  ZIEMANN ROBERT N

Inventor： BROPHY SUSAN E ,  CHI LIANLI ,  DATWYLER SAUL A ,  HAWKSWORTH DAVID J ,  LAIRD DON M ,  MANOJ SHARMILA ,  PINKUS MARY S ,  PUCCI DOMINICK L ,  RAMSAY CAROL S ,  SOGIN DAVID C ,  TU BAILIN ,  TYNER JOAN D ,  YU ZHIGUANG ,  ZIEMANN ROBERT N

IPC: C07K16/22 ,  C07K14/515 ,  C12N5/20 ,  C12N15/13

CPC classification number: C07K16/22 ,  C07K14/475 ,  C07K2317/92 ,  G01N33/74 ,  G01N2333/475

Abstract: The present disclosure relates to glycosylated and deglycosylated human PlGF-1, methods of using the glycosylated and deglycosylated human PlGF-1, antibodies that bind to human PlGF-1, methods of using the antibodies and human PlGF-1 immunoassays and kits.

Abstract translation: 本公开涉及糖基化和去糖基化的人PlGF-1，使用糖基化和去糖基化的人PlGF-1的方法，与人PlGF-1结合的抗体，使用抗体和人PlGF-1免疫测定和试剂盒的方法。

公开(公告)号：WO2014144355A2

公开(公告)日：2014-09-18

申请号：PCT/US2014028725

申请日：2014-03-14

Applicant: ABBOTT LAB

Inventor： TU BAILIN ,  ZIEMANN ROBERT N ,  TIEMAN BRYAN C ,  HEMKEN PHILIP M ,  RAMSAY CAROL S ,  STROBEL CAROLYN J ,  HAWKSWORTH DAVID J ,  BIRKENMEYER LARRY G ,  ZHAO CHENG ,  BROPHY SUSAN E ,  DOWELL BARRY L ,  MUERHOFF ANTHONY S

IPC: C07K16/18

CPC classification number: C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/57438 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2800/085 ,  G01N2800/50

Abstract: Disclosed herein are antibodies and methods of using said antibodies to detect Golgi protein 73 (GP73) and fucosylated GP73 in a sample.

Abstract translation: 本文公开了使用所述抗体检测样品中的高尔基体蛋白73（GP73）和岩藻糖基化GP73的抗体和方法。

公开(公告)号：WO2009086398A3

公开(公告)日：2009-11-19

申请号：PCT/US2008088199

申请日：2008-12-23

Applicant: ABBOTT LAB ,  BROPHY SUSAN E ,  HAWKSWORTH DAVID J ,  SHAH DINESH O ,  SIEGEL ROBERT W ,  TIEMAN BRYAN C ,  TU BAILIN ,  ZIEMANN ROBERT N ,  TYNER LOWELL

Inventor： BROPHY SUSAN E ,  HAWKSWORTH DAVID J ,  SHAH DINESH O ,  SIEGEL ROBERT W ,  TIEMAN BRYAN C ,  TU BAILIN ,  ZIEMANN ROBERT N ,  TYNER JOAN D

IPC: C07K16/20 ,  G01N33/569

CPC classification number: G01N33/56905 ,  C07K16/20 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/44 ,  G01N2469/10 ,  G01N2469/20 ,  G01N2496/00

Abstract: The present disclosure is directed to reagents and methods of using the reagents to detect epitopes of Trypanosoma cruzi.

Abstract translation: 本公开涉及使用所述试剂来检测克氏锥虫表位的试剂和方法。

公开(公告)号：WO2009052400A1

公开(公告)日：2009-04-23

申请号：PCT/US2008080340

申请日：2008-10-17

Applicant: ABBOTT LAB ,  BIRKENMEYER LARRY G ,  DESAI SURESH M ,  HAWKSWORTH DAVID J ,  OLEJNICZAK EDWARD T ,  RUAN QIAOQIAO ,  SIEGEL ROBERT W ,  TESTIN SERGE Y ,  TIEMAN BRYAN C ,  TU BAILIN ,  TYNER JOAN D ,  ZIEMANN ROBERT N

Inventor： BIRKENMEYER LARRY G ,  DESAI SURESH M ,  HAWKSWORTH DAVID J ,  OLEJNICZAK EDWARD T ,  RUAN QIAOQIAO ,  SIEGEL ROBERT W ,  TESTIN SERGE Y ,  TIEMAN BRYAN C ,  TU BAILIN ,  TYNER JOAN D ,  ZIEMANN ROBERT N

IPC: C07K16/18

CPC classification number: C07K14/47 ,  C07K2317/56 ,  C07K2317/92 ,  Y10T436/105831

Abstract: The present invention relates to antibodies specific for glycosylated mammalian NGAL, and to methods of making and using such antibodies.

Abstract translation: 本发明涉及糖基化哺乳动物NGAL的特异性抗体，以及制备和使用这种抗体的方法。

公开(公告)号：WO2009023331A2

公开(公告)日：2009-02-19

申请号：PCT/US2008063930

申请日：2008-05-16

Applicant: ABBOTT LAB ,  DATWYLER SAUL A ,  HAWKSWORTH DAVID J ,  HSU STEPHEN C ,  MATIAS MATTHEW S ,  PACENTI DAVID P ,  PINKUS MARY S ,  SHIH JESSIE W ,  TIEMAN BRYAN C ,  TYNER JOAN D ,  ZIEMANN ROBERT N

Inventor： DATWYLER SAUL A ,  HAWKSWORTH DAVID J ,  HSU STEPHEN C ,  MATIAS MATTHEW S ,  PACENTI DAVID P ,  PINKUS MARY S ,  SHIH JESSIE W ,  TIEMAN BRYAN C ,  TYNER JOAN D ,  ZIEMANN ROBERT N

IPC: C12Q1/28 ,  G01N33/573

CPC classification number: G01N33/573 ,  C12Q1/28 ,  G01N2333/908 ,  G01N2800/32 ,  G01N2800/50 ,  G01N2800/56

Abstract: The present disclosure relates to isolated antibodies that can be used in an assay to determine the concentration levels of myeloperoxidase (MPO) in a test sample. Additionally, the present disclosure also relates to the use of improved test sample handling methods in assays in order to preserve the original MPO levels in the test sample.

Abstract translation: 本公开涉及可用于测定中以测定测试样品中髓过氧化物酶（MPO）的浓度水平的分离的抗体。 另外，本公开还涉及在测定中使用改进的测试样品处理方法以保留测试样品中的原始MPO水平。

公开(公告)号：WO2008070727A2

公开(公告)日：2008-06-12

申请号：PCT/US2007086516

申请日：2007-12-05

Applicant: ABBOTT LAB ,  TU BAILIN ,  TYNER JOAN D ,  SCHEFFEL JAMES W ,  WHITE MICHAEL K ,  WERNEKE JEFFREY M ,  ZIEMANN ROBERT N ,  HAWKSWORTH DAVID J ,  PINKUS MARY S ,  GUTIERREZ ROBIN A

Inventor： TU BAILIN ,  TYNER JOAN D ,  SCHEFFEL JAMES W ,  WHITE MICHAEL K ,  WERNEKE JEFFREY M ,  ZIEMANN ROBERT N ,  HAWKSWORTH DAVID J ,  PINKUS MARY S ,  GUTIERREZ ROBIN A

IPC: C07H21/04 ,  C07K16/18 ,  C12N5/06 ,  G01N33/53

CPC classification number: G01N33/5767 ,  C07K16/109 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92

Abstract: Recombinant antibodies, including chimeric antibodies, specific for hepatitis C (HCV) antigenic proteins are provided. The recombinant antibodies specifically bind to diagnostically relevant regions of HCV proteins and are thus suitable for use, for example, as diagnostic reagents for the detection of HCV, and/or as standardization reagents or positive control reagents in assays for the detection of HCV. The recombinant antibodies can also be used in the treatment or prevention of a HCV infection.

Abstract translation: 提供了对丙型肝炎（HCV）抗原蛋白特异性的重组抗体，包括嵌合抗体。 重组抗体特异性结合HCV蛋白的诊断相关区域，因此适合用作检测HCV的诊断试剂，和/或用于检测HCV的测定中的标准化试剂或阳性对照试剂。 重组抗体也可用于治疗或预防HCV感染。

公开(公告)号：WO2006088700A2

公开(公告)日：2006-08-24

申请号：PCT/US2006004318

申请日：2006-02-08

Applicant: ABBOTT LAB ,  SHIH JESSIE W ,  TYNER JOAN D ,  MATIAS MATTHEW S ,  PINKUS MARY S ,  BROPHY SUSAN E ,  DAGHFAL DAVID J ,  HAWKSWORTH DAVID J ,  TIEMAN BRYAN C

Inventor： SHIH JESSIE W ,  TYNER JOAN D ,  MATIAS MATTHEW S ,  PINKUS MARY S ,  BROPHY SUSAN E ,  DAGHFAL DAVID J ,  HAWKSWORTH DAVID J ,  TIEMAN BRYAN C

IPC: C07K16/26 ,  C12N5/20 ,  G01N33/53

CPC classification number: C07K16/26 ,  C07K2317/34 ,  C07K2317/92

Abstract: The present invention relates to antibodies that specifically bind to human BNP and immunoassays using said antibodies in the quantification of human BNP or a fragment of human BNP in a test sample.

Abstract translation: 本发明涉及在测试样品中定量人BNP或人BNP片段时使用所述抗体特异性结合人BNP和免疫测定的抗体。