公开(公告)号：WO1997022291A1

公开(公告)日：1997-06-26

申请号：PCT/US1996018870

申请日：1996-11-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HENNING, Timothy, P. ,  SHAIN, Eric, B. ,  KHALIL, Gamal ,  ELSTROM, Tuan, A.

IPC: A61B05/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/6848

Abstract: The present invention relates to a device (10) for the sampling of blood or other body fluids which includes means (16) for the direct measurement of the analyte of interest within the fluid. Also disclosed is a "closed-loop" device and method wherein the analyte is measured and the required amount of drug is determined and injected, without removal of the device from the patient's body.

Abstract translation: 本发明涉及一种用于对血液或其他体液进行取样的装置（10），其包括用于直接测量流体内感兴趣分析物的装置（16）。 还公开了一种“闭环”装置和方法，其中测量分析物，并且确定和注射所需量的药物，而不从装置从患者身体移除。

公开(公告)号：WO1997030749A1

公开(公告)日：1997-08-28

申请号：PCT/US1997002264

申请日：1997-02-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ELSTROM, Tuan, A. ,  SHAIN, Eric, B. ,  HENNING, Timothy, P.

IPC: A61M37/00

CPC classification number: A61B5/14514 ,  A61M37/0092 ,  A61M2037/0007

Abstract: A process for the sampling of extracellular fluid across the skin of an animal involves establishing an ultrasonic standing wave across the skin and collecting fluid transudate. Sampling can be enhanced by combining the use of ultrasound with the application of a partial vacuum to the surface of the skin. An apparatus includes an ultrasonic transducer, a reflector and an absorbent material for collecting transudate. The apparatus can further include a pressure component for reducing hydrostatic pressure on the skin surface.

Abstract translation: 跨越动物皮肤取样细胞外液的过程包括在皮肤上建立超声驻波并收集流体渗出物。 可以通过将超声波与部分真空的应用组合到皮肤表面来增强采样。 一种装置包括超声换能器，反射器和用于收集渗出物的吸收材料。 该装置还可以包括用于降低皮肤表面上的静水压力的压力分量。

公开(公告)号：WO1997032521A1

公开(公告)日：1997-09-12

申请号：PCT/US1997002824

申请日：1997-02-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OOSTA, Gary, M. ,  ELSTROM, Tuan, A. ,  SHAIN, Eric, B. ,  SCHAPIRA, Thomas, G.

IPC: A61B05/103

CPC classification number: A61B5/1495 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/442 ,  A61B5/443

Abstract: A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual using non-ionizing radiation is provided. The process includes determining the contribution of one or more skin parameters to the absorption and transmittance data and correcting the subsequent non-invasive measurement of the biological compound for the contribution of the parameter(s).

Abstract translation: 提供了使用非电离辐射来校准个体以准备对该个体的皮肤进行的非侵入式测量生物化合物的过程。 该过程包括确定一个或多个皮肤参数对吸收和透射率数据的贡献，并校正生物化合物的后续非侵入​​性测量以用于参数的贡献。

公开(公告)号：WO1997030628A1

公开(公告)日：1997-08-28

申请号：PCT/US1997002483

申请日：1997-02-14

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  SHAIN, Eric, B. ,  ELSTROM, Tuan, A. ,  SCHAPIRA, Thomas, G. ,  HENNING, Timothy, P.

IPC: A61B05/00

CPC classification number: A61B5/14514 ,  A61B5/14532

Abstract: The combined use of an ultrasound source (12) and a pressure-reducing means (14) for the enhancement of transdermal transport of fluids in fluid sampling methods, and for the detection of analytes in a patient's blood.

Abstract translation: 组合使用超声波源（12）和减压装置（14），用于增强流体采样方法中的流体的透皮转运，以及检测患者血液中的分析物。

公开(公告)号：WO1997022292A1

公开(公告)日：1997-06-26

申请号：PCT/US1996019902

申请日：1996-12-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HENNING, Timothy, P. ,  SHAIN, Eric, B. ,  ELSTROM, Tuan, A. ,  WARNKE, Kevin, C.

IPC: A61B05/00

CPC classification number: A61B5/441 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/15134 ,  A61B5/157

Abstract: This disclosure relates to a device and method for the non-invasive or minimally invasive withdrawal of fluids from a patient by the use of a self-actuated pump (12) connected to an analyte sensing unit (16). The self-actuated pump (12) is preferably mounted in the patient's shoe (38).

Abstract translation: 本公开涉及一种用于通过使用连接到分析物感测单元（16）的自动泵（12）从患者非侵入性或最小程度地取出流体的装置和方法。 自动泵（12）优选安装在患者鞋（38）中。