公开(公告)号：WO1996010747A1

公开(公告)日：1996-04-11

申请号：PCT/US1995012462

申请日：1995-09-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  HANSMANN, Douglas, D. ,  GRACE, John, P. ,  LOWERY, Michael, G. ,  OOSTA, Gary, M. ,  LOOMIS, Neil, W. ,  SHAIN, Eric, B. ,  SCHAPIRA, Thomas, G.

IPC: G01N33/543

CPC classification number: G01N33/5304 ,  B01L3/502746 ,  B01L3/502753 ,  B01L2200/10 ,  B01L2300/0636 ,  B01L2300/0825 ,  B01L2400/0406 ,  B01L2400/086 ,  C08G18/0866 ,  C08G18/10 ,  G01N33/54366 ,  G01N33/54393 ,  Y10S435/81 ,  Y10S436/804 ,  Y10S436/805 ,  Y10S436/809 ,  Y10S436/81

Abstract: The present invention relates to analytical devices for determining the presence or amount of an analyte in a test sample. The analytical devices comprise an inlet port, a vent, a channel, and an array of structures. The structures have immobilized reagent covalently or non-covalently attached to the surface of the structures. The immobilized reagent captures analyte in the test sample where it is detected by a detection system. The present invention also provides methods and reagents for performing assays utilizing the analytical devices of the present invention. The present invention also provides methods of manufacturing the analytical devices of the present invention.

Abstract translation: 本发明涉及用于确定测试样品中分析物的存在或量的分析装置。 分析装置包括入口，通气口，通道和结构阵列。 这些结构具有共价或非共价连接到结构表面的固定化试剂。 固定化的试剂捕获测试样品中的分析物，由检测系统检测。 本发明还提供用于使用本发明的分析装置进行测定的方法和试剂。 本发明还提供了制造本发明的分析装置的方法。

公开(公告)号：WO1997032521A1

公开(公告)日：1997-09-12

申请号：PCT/US1997002824

申请日：1997-02-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OOSTA, Gary, M. ,  ELSTROM, Tuan, A. ,  SHAIN, Eric, B. ,  SCHAPIRA, Thomas, G.

IPC: A61B05/103

CPC classification number: A61B5/1495 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/442 ,  A61B5/443

Abstract: A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual using non-ionizing radiation is provided. The process includes determining the contribution of one or more skin parameters to the absorption and transmittance data and correcting the subsequent non-invasive measurement of the biological compound for the contribution of the parameter(s).

Abstract translation: 提供了使用非电离辐射来校准个体以准备对该个体的皮肤进行的非侵入式测量生物化合物的过程。 该过程包括确定一个或多个皮肤参数对吸收和透射率数据的贡献，并校正生物化合物的后续非侵入​​性测量以用于参数的贡献。

公开(公告)号：WO1995017966A1

公开(公告)日：1995-07-06

申请号：PCT/US1994014936

申请日：1994-12-28

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OOSTA, Gary, M. ,  SCHAPIRA, Thomas, G.

IPC: B01L03/00

CPC classification number: G01N33/54386 ,  B01L3/502723 ,  B01L2200/0684 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  Y10T436/255

Abstract: Methods and devices are provided involving an inlet port, at least one chamber, a channel providing access for fluids to flow through via capillary action or differential pressure, reagents, detection means and self-venting materials. The devices allow for the appropriate mixing, reacting, incubating needed to give a detectable signal which can be read. The self-venting materials allow for the 1) displacement of gases inside a track to the outside of the device and 2) oxygen movement into the track from the outside.

Abstract translation: 提供的方法和装置包括入口端口，至少一个腔室，通道，用于通过毛细作用或差压流体流过流体，试剂，检测装置和自排气材料。 这些装置允许适当的混合，反应，孵育所需的，以产生可读信号。 自放气材料允许1）将轨道内的气体置换到设备外部，以及2）氧气从外部进入轨道。