公开(公告)号：WO2017035501A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/049084

申请日：2016-08-26

Applicant: ACADEMIA SINICA ,  LIANG, Chi-Ming

Inventor： LI, Wen-Shan ,  HUNG, Wen-Chun ,  SHEN, Chia-Ning

IPC: C07J9/00 ,  A61P35/00 ,  C07J11/00 ,  C07J15/00 ,  C12N9/10

CPC classification number: C07J73/005 ,  C07J9/005 ,  C07J41/0005 ,  C07J41/0055 ,  C07J43/003 ,  C07J63/00 ,  C07J73/003

Abstract: Disclosed herein are novel sialyltransferase inhibitors, and compositions and methods for treating diseases and/or conditions associated with the activation of sialyltransferase, such as a cancer, an immune disease or an inflammatory disease.

Abstract translation: 本文公开了新的唾液酸转移酶抑制剂，以及用于治疗与唾液酸转移酶活化相关的疾病和/或病症的组合物和方法，例如癌症，免疫疾病或炎性疾病。

公开(公告)号：WO2022197564A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/020074

申请日：2022-03-11

Applicant: ACADEMIA SINICA ,  LIU, Fu-Tong

Inventor： CHENG, Wei-Chieh ,  CHEN, Wei-An ,  CHEN, Yu-Hsin ,  CHENG, Ting-Jen ,  SHEN, Chia-Ning ,  HSIEH, Chiao-Yun ,  HUNG, Pi-Fang

IPC: A61K31/395 ,  A61K31/40 ,  A61K31/407 ,  C07D403/02 ,  C07D487/00 ,  C07D487/04

Abstract: Disclosed herein are novel polyhydroxylated indolizidine and pyrrolizidine derivates and methods for using the same in the treatment of cancer. The present poly hydroxylated indolizidine and pyrrolizidine derivates has the structure of formula (I), wherein: X is 0 or S; a, b and c are independently an integral of 0 or 1; and R is selected from the group consisting of H, C1-6 alkyl, alkenyl, alkynyl, and, heteroawl, cycloalkyl. cycloalkenyl, aralkyl, aralkenyl, aralkynyl, heteroaralkyl, heteroaralkenyl, heteroaralkynyl. heterocyclyl, alkoxy, aryloxy, and sulfonyl.