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公开(公告)号：WO2017127753A1
公开(公告)日：2017-07-27
申请号：PCT/US2017/014446
申请日：2017-01-20
Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.
Inventor： HARWIG, Curtis , SEENISAMY, Jeyaprakashnarayanan , KEREGADDE, Mahesh, Narayan, , CHETIA, Lakshindra
IPC: C07D307/77 , C07C209/40 , C07C211/25 , C07C13/465
CPC classification number: C07C209/30 , C07B2200/07 , C07C213/00 , C07C249/12 , C07C2101/14 , C07C2102/02 , C07C2601/14 , C07C2602/02 , C07C2602/24 , C07D307/77 , C07D317/70 , C07D317/72 , C07J1/0011 , C07J1/0022 , C07J13/007 , C07J21/008 , C07J31/006 , C07J51/00 , C07J71/0026 , C07J73/003 , C07J73/005 , C07C215/42
Abstract: This invention is directed to methods of preparing AQX-1125 having the formula (I). This invention is also directed to intermediates utilized in the methods of preparing AQX-1125.
Abstract translation: 本发明涉及制备具有式（I）的AQX-1125的方法。 本发明还涉及用于制备AQX-1125的方法中的中间体。
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2.发明申请PREPARATION OF 6-OXA-8ALPHA-STEROID ESTROGEN ANALOGUES - A NEW GROUP OF UNNATURAL ESTROGENS AND THEIR USE IN MEDICINE 审中-公开6-OXA-8ALPHA-STEROID雌激素类似物的制备 - 一组新的独特的雌激素及其在医学中的应用
公开(公告)号：WO2009059806A3
公开(公告)日：2009-10-29
申请号：PCT/EP2008009619
申请日：2008-11-10
Applicant: TOPASS GMBH , PISON ULRICH , SHAVVA ALEXANDER GRIGORIEVICH , MOROZKINA SVETLANA NIKOLAEVNA
IPC: C07J73/00 , A61K31/56 , A61K31/566 , A61P5/30
CPC classification number: C07J73/003
Abstract: The invention is related to the area of new 6-Oxa-8a-steroid estrogen analogues and the synthesis of these new biological active steroid estrogen analogues, namely, to the preparation of 6-oxa-8a-steroid estrogens and their use as estrogen receptor modulators. These new estrogen analogues are ligands for estrogen receptors and as such may be useful for the treatment and prevention of a variety of conditions related to estrogen functioning. These conditions include bone and cartilage disorders, increased levels of LDL cholesterol, cardiovascular diseases, impairment of cognitive function, cerebral degeneration disorders, endometriosis and other types of inflammation, the metabolic syndrome, and cancer, in particular of the breast, uterus and prostate.
Abstract translation: 本发明涉及新的6-Oxa-8a-类固醇雌激素类似物的面积和这些新的生物活性类固醇雌激素类似物的合成，即6-氧杂-8a类固醇雌激素的制备及其作为雌激素受体的用途 调制器。 这些新的雌激素类似物是雌激素受体的配体，因此可用于治疗和预防与雌激素功能相关的各种病症。 这些病症包括骨和软骨障碍，LDL胆固醇水平升高，心血管疾病，认知功能障碍，脑变性障碍，子宫内膜异位症和其他类型的炎症，代谢综合征和癌症，特别是乳腺，子宫和前列腺。
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公开(公告)号：WO2009124460A1
公开(公告)日：2009-10-15
申请号：PCT/CN2009/000360
申请日：2009-04-02
CPC classification number: C07J73/003 , C07J21/00 , C07J33/00 , C07J71/00
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公开(公告)号：WO2007147713A1
公开(公告)日：2007-12-27
申请号：PCT/EP2007/055366
申请日：2007-05-31
Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. , CERRI, Alberto , MORO, Barbara , TORRI, Maco , CARZANA, Giulio , BIANCHI, Giuseppe , FERRANDI, Mara , FERRARI, Patrizia , ZAPPAVIGNA, Maria Pia , BANFI, Leonardo , GIACALONE, Giuseppe
Inventor： CERRI, Alberto , MORO, Barbara , TORRI, Maco , CARZANA, Giulio , BIANCHI, Giuseppe , FERRANDI, Mara , FERRARI, Patrizia , ZAPPAVIGNA, Maria Pia , BANFI, Leonardo , GIACALONE, Giuseppe
IPC: C07J3/00 , C07J63/00 , A61K31/58 , A61K31/565 , A61K31/566 , A61P9/04 , A61P9/06
CPC classification number: C07J73/005 , C07J63/004 , C07J73/003
Abstract: New aminoalkoxyimino derivatives at position 3 of substituted B- homoandrostanes and B-heteroandrostanes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described, where the radicals have the meanings described in detail in the application.
Abstract translation: 取代的B-雄性雄甾烷和B-异雄甾烷砜的3位的新的氨基烷氧基亚氨基衍生物，其制备方法，以及含有它们用于治疗心力衰竭和高血压的心血管疾病的药物组合物。 特别地描述了具有通式（I）的化合物，其中基团具有本申请中详细描述的含义。
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公开(公告)号：WO2004064722A3
公开(公告)日：2004-11-18
申请号：PCT/US0239673
申请日：2002-12-11
Applicant: ENDEAVOR PHARMACEUTICALS INC
Inventor： DESAI SHAILESHKUMAR RAMANLAL , RAY DAVID WAYNE JR , SAYED YOUSRY A
IPC: C07D311/78 , C07D311/94 , C07J1/00 , C07J73/00 , C07D321/00 , C07D309/00
CPC classification number: C07D311/94 , C07D311/78 , C07J1/0037 , C07J73/003
Abstract: The present invention relates to a process for the synthesis of oxandrolone from mestanolone. The process comprises the steps of: (a) oxidizing mestanolone to form 17beta -hydroxy-17alpha -methyl-5 -androst-1-en-3-one; (b) hydroxylating the 17beta - hydroxy-17alpha -methyl-5alpha -androst-1-en-3-one to form 1alpha , 2alpha , 17beta -trihydroxy-17alpha - methylandrostan-3-one; (c) cleaving the 1alpha , 2alpha , 17beta -trihydroxy-17alpha -methylandrostan-3- one to form 17beta -hydroxy-17alpha -methyl-1-oxo-1,2,-seco-A-nor-5 -androstan-2-oic acid; and (d) reducing the 17beta -hydroxy-17 -methyl-1-oxo-1,2,-seco-A-nor-5alpha -androstan-2-oic acid to form oxandrolone.
Abstract translation: 本发明涉及从mestanolone合成氧杂雄酮的方法。 该方法包括以下步骤：（a）氧化mestanolone以形成17β-羟基-17α-甲基-5-雄甾-1-烯-3-酮; （b）使17β-羟基-17α-甲基-5α-雄甾-1-烯-3-酮羟基化形成1α，2α，17β-三羟基-17α-甲基雄甾-3-酮; （c）切割1α，2α，17β-三羟基-17α-甲基雄甾烷-3-酮以形成17β-羟基-17α-甲基-1-氧代-1,2'-环十一碳-5-雄甾烷-2 - 酸; 和（d）还原17β-羟基-17-甲基-1-氧代-1,2， - 异-α-降-5α-雄烷-2-烯酸以形成氧雄龙。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2004074305A2
公开(公告)日：2004-09-02
申请号：PCT/US2004004548
申请日：2004-02-13
Applicant: BARR LAB INC , PONDER GARRATT W
Inventor： PONDER GARRATT W
IPC: C07D311/78 , C07D493/00 , C07J20060101 , C07J
CPC classification number: C07J73/003
Abstract: The present invention relates to processes for the production of 2-oxa-3-one androstane derivatives. The processes comprise reacting a 3-one androstane derivative with ozone to form a 2-oxa-3-one androstane derivative.
Abstract translation: 本发明涉及2-氧杂-3-酮雄甾烷衍生物的制备方法。 该方法包括使3-酮雄甾烷衍生物与臭氧反应以形成2-氧杂-3-酮的雄甾烷衍生物。
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公开(公告)号：WO2013106975A1
公开(公告)日：2013-07-25
申请号：PCT/CN2012/001156
申请日：2012-08-28
Applicant: 成都新朝阳作物科学有限公司 , 何其明
Inventor： 何其明
CPC classification number: A01N35/04 , A01N43/22 , A01N45/00 , A01N65/00 , A01N65/08 , C07J9/00 , C07J73/003
Abstract: 本发明提供了提取自植物的芸苔素内酯类似物的提取及其应用，包括促进植物生长、抗低温和耐高盐等方面的应用。另外，本发明还提供了包含该芸苔素内酯类似物的农用组合物。
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公开(公告)号：WO2011088160A3
公开(公告)日：2011-10-13
申请号：PCT/US2011021043
申请日：2011-01-13
Applicant: BIOMARIN PHARM INC , CHU DANIEL , WANG BING , YE TAO
Inventor： CHU DANIEL , WANG BING , YE TAO
IPC: C07J61/00 , A61P5/28 , C07D487/04 , C07J73/00
CPC classification number: C07J73/003 , C07D211/76 , C07D233/60 , C07D241/12 , C07D249/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07J61/00 , C07J73/005 , C07J73/006 , C07J73/008
Abstract: Provided herein are inhibitors of CYP17 enzyme. Also described herein are pharmaceutical compositions that include at least one compound described herein and the use of a compound or pharmaceutical composition described herein to treat androgen-dependent diseases, disorders and conditions.
Abstract translation: 本文提供了CYP17酶的抑制剂。 本文还描述了包含至少一种本文所述化合物的药物组合物以及本文所述化合物或药物组合物用于治疗雄激素依赖性疾病，病症和病症的用途。
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9.发明申请
公开(公告)号：WO2008125069A3
公开(公告)日：2009-02-05
申请号：PCT/CZ2008000044
申请日：2008-04-14
Applicant: USTAV ORGANICKE CHEMIE A BIOCH , MACEK THOMAS , UHLIK ONDREJ , KAMLAR MAREK , HARMATHA JURAJ , KOHOUT LADISLAV
Inventor： MACEK THOMAS , UHLIK ONDREJ , KAMLAR MAREK , HARMATHA JURAJ , KOHOUT LADISLAV
CPC classification number: C07J73/003 , A01H3/04 , A01N59/16 , A01N61/00 , C12N9/88 , Y02P60/247 , A01N45/00 , A01N45/02 , A01N2300/00
Abstract: This invention deals with a method of increasing the yield of photosynthetic assimilation of carbon dioxide in plants by means of application of agents that increase the carboxylase activity of the enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO, EC 4.1.1.39). It leads as to increase of green mass of agricultural products as decrease of carbon dioxide in atmosphere.
Abstract translation: 本发明涉及一种增加植物中二氧化碳的光合同化产率的方法，该方法是通过使用增加酶核酮糖1,5-二磷酸羧化酶/加氧酶（RuBisCO，EC 4.1.1.39）的羧化酶活性的试剂。 导致大气中二氧化碳减少导致农产品绿色增长。
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公开(公告)号：WO2007059008A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/043933
申请日：2006-11-13
Applicant: PURDUE RESEARCH FOUNDATION , THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES , CUSHMAN, Mark, S. , MORRELL, Andrew, E. , NAGARAJAN, Muthukaman , POMMIER, Yves, G.
Inventor： CUSHMAN, Mark, S. , MORRELL, Andrew, E. , NAGARAJAN, Muthukaman , POMMIER, Yves, G.
IPC: C07D221/18 , A61K31/473 , A61K31/4741
CPC classification number: C07J73/005 , A61K31/473 , A61K31/4741 , C07D221/18 , C07D311/94 , C07J73/003
Abstract: N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.
Abstract translation: 描述了N-取代的茚并异喹啉化合物和N-取代的茚并异喹啉化合物的药物制剂。 还描述了制备N-取代的茚并异喹啉化合物的方法。 还描述了使用所述的N-取代的茚并异喹啉化合物或其药物制剂治疗哺乳动物癌症的方法。
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