公开(公告)号：WO1990012825A1

公开(公告)日：1990-11-01

申请号：PCT/EP1990000728

申请日：1990-04-26

Applicant: AKZO N.V. ,  SAINT PETER S.R.L. ,  GIOVANDO, Gualtiero

Inventor： AKZO N.V. ,  SAINT PETER S.R.L.

IPC: C08F299/04

CPC classification number: C08F299/06 ,  C08F299/04 ,  C08F299/0464 ,  C08K5/37

Abstract: An accelerator composition for the curing of unsaturated maleic, allylic, vinylic and epoxy-type polyester resins is disclosed. The accelerator composition includes a complex of a salt of a metal selected from lithium, copper, manganese, magnesium, vanadium, iron and cobalt, with an oxygen-containing compound which is capable of forming a complex with the metal salt and includes at least one functional group selected from aldehyde, ketone, ether, ester and alcohol. Also disclosed are a curable resin composition including the foregoing accelerators and a curing process employing these accelerators.

公开(公告)号：WO1990012824A1

公开(公告)日：1990-11-01

申请号：PCT/EP1990000727

申请日：1990-04-26

Applicant: AKZO N.V. ,  SAINT PETER S.R.L. ,  GIOVANDO, Gualtiero

Inventor： AKZO N.V. ,  SAINT PETER S.R.L.

IPC: C08F299/04

CPC classification number: C08G59/686 ,  C08F299/04 ,  C08F299/0464 ,  C08K5/0091

Abstract: Accelerator compositions for the curing of unsaturated maleic, vinylic, allylic and epoxy-type polyesters, are disclosed. The accelerator compositions comprise a complex of a salt of a metal selected from lithium, vanadium, copper, nickel, magnesium, iron and cobalt, and a nitrogen-containing compound capable of forming a complex with these metal salts and being selected from ammonia, ammonium salts, amines, amides, heterocyclic nitrogen compounds and their adducts with anhydrides and epoxides. Also disclosed are a curable composition comprising resin and the accelerator composition of the invention and a curing process carried out in the presence of an accelerator composition of the invention.

Abstract translation: 公开了用于固化不饱和马来酸，乙烯基，烯丙基和环氧型聚酯的促进剂组合物。 促进剂组合物包含选自锂，钒，铜，镍，镁，铁和钴的金属盐和能够与这些金属盐形成络合物的含氮化合物的复合物，并且选自氨，铵 盐，胺，酰胺，杂环氮化合物及其与酸酐和环氧化物的加合物。 还公开了包含本发明的树脂和促进剂组合物的固化性组合物和在本发明的促进剂组合物存在下进行的固化过程。

公开(公告)号：WO1990012826A1

公开(公告)日：1990-11-01

申请号：PCT/EP1990000729

申请日：1990-04-26

Applicant: AKZO N.V. ,  SAINT PETER S.R.L. ,  GIOVANDO, Gualtiero

Inventor： AKZO N.V. ,  SAINT PETER S.R.L.

IPC: C08F299/04

CPC classification number: C08G59/687 ,  C08F299/04 ,  C08F299/0464 ,  C08F299/06 ,  C08G59/66 ,  C08K5/37

Abstract: Accelerator compositions for the free radical polymerization of unsaturated polyesters and for the curing of unsaturated polyesters and polyurethanes are disclosed. More particularly, use is made of complexes of thiolic compounds with metal salts as the accelerators. In more preferred embodiments, the accelerators also include oxygen-containing compounds or phosphorus-containing compounds. Also disclosed are curable resin compositions comprising these accelerators and polymerization and curing processes employing these accelerators.

Abstract translation: 公开了用于不饱和聚酯的自由基聚合和不饱和聚酯和聚氨酯固化的促进剂组合物。 更具体地，使用硫醇化合物与金属盐作为促进剂的络合物。 在更优选的实施方案中，促进剂还包括含氧化合物或含磷化合物。 还公开了包含这些促进剂的可固化树脂组合物和使用这些促进剂的聚合和固化方法。

公开(公告)号：WO1994019337A1

公开(公告)日：1994-09-01

申请号：PCT/US1994001424

申请日：1994-02-08

Applicant: AKZO N.V. ,  MAROLEWSKI, Theodore, A. ,  BURKHARDT, Eric, W. ,  WALLFAHRER, Uwe, H.

Inventor： AKZO N.V.

IPC: C07D285/125

CPC classification number: C08F8/40 ,  C08F222/14 ,  C08F267/06 ,  C08F2800/10 ,  C08F210/14 ,  C08F2220/325 ,  C08F230/02

Abstract: Epoxy functional copolymers of a higher alpha -olefin, and an unsaturated dicarboxylic acid ester formed by copolymerization of olefin, acid ester and ethylenically unsaturated glycidyl compound can be used to form nitrogen, oxygen, phosphorus and/or sulfur-containing lubricant additives by reaction of the epoxy functionality in such a copolymer with glycidyl-reactive compounds containing nitrogen, oxygen, phosphorus and/or sulfur atoms. Alternatively, the copolymerization reaction can utilize the olefin, unsaturated acid ester, and an ethylenically unsaturated compound containing the nitrogen, phosphorus and/or sulfur atom, which compound is formed by reaction of ethylenically unsaturated glycidyl compound and an epoxy-reactive nitrogen, phosphorus, and/or sulfur-containing compound.

Abstract translation: 通过烯烃，酸酯和烯键式不饱和缩水甘油基化合物的共聚而形成的高级α-烯烃和不饱和二羧酸酯的环氧官能团共聚物可用于形成氮，氧，磷和/或含硫润滑剂添加剂， 这种共聚物中含有含氮，氧，磷和/或硫原子的缩水甘油基反应性化合物的环氧官能度。 或者，共聚反应可以利用烯烃，不饱和酸酯和含有氮，磷和/或硫原子的烯属不饱和化合物，该化合物是通过烯键式不饱和缩水甘油基化合物与环氧反应性氮，磷， 和/或含硫化合物。

公开(公告)号：WO1994006912A1

公开(公告)日：1994-03-31

申请号：PCT/EP1993002478

申请日：1993-09-13

Applicant: AKZO N.V. ,  MIDDELDORP, Jaap, Michiel

Inventor： AKZO N.V.

IPC: C12N15/38

CPC classification number: C07K16/087 ,  C07K14/005 ,  C12N2710/16222

Abstract: The invention relates to a peptide or fragment thereof which is immunochemically reactive with Epstein-Barr Virus (EBV) antibodies. A new monoclonal antibody directed to said peptide or fragment thereof is also part of the invention. The invention also relates to a method for the detection of EBV or anti-EBV antibodies in a test fluid and also to an immunochemical reagent comprising a peptide, a fragment or a polypeptide according to the invention and a test kit to be used when applying the said detection methods. Detection of EBV in a test fluid or tissue specimen using antibodies, monoclonal and polyclonal, directed to the said peptide, which have the characteristics of detecting both native and denatured intact, functional EBNA-1 protein is also part of said invention.

Abstract translation: 本发明涉及与爱泼斯坦 - 巴尔病毒（EBV）抗体免疫化学反应的肽或其片段。 针对所述肽或其片段的新单克隆抗体也是本发明的一部分。 本发明还涉及一种用于在测试流体中检测EBV或抗EBV抗体的方法，还涉及包含根据本发明的肽，片段或多肽的免疫化学试剂以及当应用本发明时使用的测试试剂盒 说检测方法。 使用具有检测天然和变性完整的功能性EBNA-1蛋白的特征的针对所述肽的抗体（单克隆抗体和多克隆抗体）检测试验液或组织标本中的EBV也是所述发明的一部分。

公开(公告)号：WO1994003621A1

公开(公告)日：1994-02-17

申请号：PCT/EP1993001971

申请日：1993-07-23

Applicant: AKZO N.V. ,  SONDERMEIJER, Paulus, Jacobus, Antonius ,  WILLEMSE, Martha, Jacoba

Inventor： AKZO N.V.

IPC: C12N15/86

CPC classification number: C12N15/86 ,  A61K39/00 ,  C07K14/005 ,  C12N2710/16722 ,  C12N2710/16743

Abstract: The present invention is concerned with a Feline herpesvirus (FHV) mutant comprising a heterologous gene introduced into a section of the FHV genome. The invention also relates to a vector vaccine comprising such an FHV mutant which expresses a heterologous polypeptide derived from a feline pathogen and induces an adequate immune response in an inoculated host against both FHV and the feline pathogen.

Abstract translation: 本发明涉及包含引入FHV基因组部分的异源基因的猫疱疹病毒（FHV）突变体。 本发明还涉及包含这样的FHV突变体的载体疫苗，其表达源自猫科病原体的异源多肽，并且在接种的宿主中对FHV和猫病原体诱导足够的免疫应答。

公开(公告)号：WO1994003250A1

公开(公告)日：1994-02-17

申请号：PCT/EP1993002007

申请日：1993-07-28

Applicant: AKZO N.V. ,  VAN DER MEER, Abele, Broer

Inventor： AKZO N.V.

IPC: B01D15/02

CPC classification number: B01D24/36

Abstract: Process for removing bottoms or isolating useful products from a liquid mixture which in addition to, e.g., water contains solid matter, in which process the mixture is passed through a packed filter bed in a vessel, characterized in that the filter bed is composed of bottoms and useful products-absorbing filter particles and situated in such a space that, when the greater part of any present solid matter or the like is passed through it, expansion or fluidisation of the filter bed may occur as the pressure in it increases during operation.

Abstract translation: 用于除去底部物质或从液体混合物中分离有用产物的方法，除了例如含有固体物质的水之外，其中混合物通过容器中的填充过滤床，其特征在于，过滤床由底部 和有用的产品吸收过滤器颗粒并且位于这样的空间中，当大部分任何存在的固体物质等通过其中时，过滤床的膨胀或流化可以随着其中的压力在操作期间增加而发生。

公开(公告)号：WO1993020938A1

公开(公告)日：1993-10-28

申请号：PCT/US1993003147

申请日：1993-04-02

Applicant: AKZO N.V. ,  KERSHNER, David, L.

Inventor： AKZO N.V.

IPC: B01J31/00

CPC classification number: C07F9/5009 ,  B01J31/0225 ,  B01J31/2239 ,  B01J31/2404 ,  B01J2531/42 ,  B01J2531/80 ,  B01J2531/824 ,  C07C45/49

Abstract: Polyketones can be formed from carbon monoxide and at least one olefin by using, as a catalytic complex, a catalyst which comprises a Group VIII metal, an anion of an acid having a pKa of less than about four, and a tin tetradentate phosphine ligand, preferably of the formula Sn(RPR'2)4 where R is methylene and R' is phenyl.

公开(公告)号：WO1993020199A1

公开(公告)日：1993-10-14

申请号：PCT/EP1993000780

申请日：1993-03-29

Applicant: AKZO N.V. ,  DIJKEMA, Rein ,  DE LEEUW, Renato

Inventor： AKZO N.V.

IPC: C12N15/12

CPC classification number: C07K14/723 ,  C07K16/2869 ,  C07K2319/02

Abstract: The present invention provides a new receptor for gonadotropins, amino acid sequences of said receptor, nucleic acid sequences coding for said receptor, recombinant hosts comprising such a nucleic acid as well as screening assays using said receptor and ligands such as antibodies for that receptor. In a more preferred embodiment the invention provides antibodies raised against the human FSH receptor. The compounds and methods of the invention will find their use in the field of reproductive medicine, particularly human reproductive medicines.

Abstract translation: 本发明提供了促性腺激素的新受体，所述受体的氨基酸序列，编码所述受体的核酸序列，包含这种核酸的重组宿主，以及使用所述受体和配体如针对该受体的抗体的筛选试验。 在更优选的实施方案中，本发明提供针对人FSH受体产生的抗体。 本发明的化合物和方法将用于生殖医学领域，特别是人类生殖药物领域。

公开(公告)号：WO1993017707A1

公开(公告)日：1993-09-16

申请号：PCT/US1993001858

申请日：1993-03-03

Applicant: AKZO N.V. ,  POMATO, Nicholas

Inventor： AKZO N.V. ,  MC CABE, Richard, P. ,  HAWKINS, Gregory, A. ,  BREDERHORST, Reinhard ,  KIM, Chong-Ho ,  VOGEL, Carl-Wilhelm

IPC: A61K39/395

CPC classification number: B82Y5/00 ,  A61K47/6897 ,  A61K51/1093 ,  A61K2121/00

Abstract: A method for in vivo targeting a functional moiety in a patient by administering a targeting moiety coupled to an affinity component, wherein the targeting moiety has affinity for binding sites in a target area, and administering a binding partner to the affinity component coupled to a functional moiety to localize the functional moiety in the target area. Preferably the targeting moiety is an antibody and the functional moiety is a radiometal when performing in vivo imaging or therapy. The affinity component may be a novel methotrexate analog.

Abstract translation: 一种通过施用与亲和组分偶联的靶向部分来体内靶向患者功能部分的方法，其中所述靶向部分对靶区域中的结合位点具有亲和性，并且向与功能性部分偶联的亲和成分施用结合配偶体 部分以定位目标区域中的功能部分。 优选地，靶向部分是抗体，并且当进行体内成像或治疗时，功能部分是放射性金属。 亲和成分可以是新型甲氨蝶呤类似物。