公开(公告)号：WO1995009235A1

公开(公告)日：1995-04-06

申请号：PCT/US1994010957

申请日：1994-09-28

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY

发明人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY ,  GOLDSTEIN, Harris ,  KOLLMANN, Tobias, R.

IPC分类号： C12N15/00

CPC分类号： A01K67/0271

摘要： BTCD-hu2 chimeric mice for assaying the pathogenesis of human disease and efficacy and toxicity of disease treatments have been developed by implantation of human fetal thymus and human fetal liver tissue under the kidney capsule of T- and B-cell deficient mice, by engraftment of human fetal bone marrow cells into T- and B-cell deficient mice and combinations of both. The resulting chimeric mice contain human T-cells, human monocytes or combinations thereof in sufficient quantity in the mouse peripheral lymphoid compartment to support HIV-1 infection following intraperitoneal inoculation of HIV-1 into the mouse.

摘要翻译： 通过在T细胞和B细胞缺陷小鼠的肾胶囊下植入人胎儿胸腺和人胎儿肝组织，研究了用于测定人类疾病发病机理和疾病治疗的功效和毒性的BTCD-hu2嵌合小鼠，通过植入 人胎儿骨髓细胞进入T细胞和B细胞缺陷小鼠以及两者的组合。 所得嵌合小鼠在小鼠外周淋巴室中含有足量的人T细胞，人单核细胞或其组合，以在将HIV-1腹膜内接种入小鼠后支持HIV-1感染。

公开(公告)号：WO2021178975A1

公开(公告)日：2021-09-10

申请号：PCT/US2021/021411

申请日：2021-03-08

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE

发明人： GOLDSTEIN, Harris ,  ALMO, Steven C. ,  GARFORTH, Scott ,  LI, Mengyan

IPC分类号： A61K31/7088 ,  A61K35/76 ,  A61K35/761 ,  A61K38/16 ,  A61K39/00 ,  A61K39/002

摘要： The present disclosure relates to a method of modulating one or more genetically modified cells, e.g., chimeric antigen receptor (CAR)-expressing cells, ex vivo and/or in vivo.

公开(公告)号：WO2021178973A1

公开(公告)日：2021-09-10

申请号：PCT/US2021/021407

申请日：2021-03-08

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE

发明人： GOLDSTEIN, Harris ,  ALMO, Steven, C. ,  GARFORTH, Scott ,  LI, Mengyan

IPC分类号： A61K48/00 ,  C07K14/00 ,  C07K14/705

摘要： Polypeptides, nucleic acids, and compositions thereof are provided that include a targeting moiety. The polypeptides, nucleic acids, and compositions that comprise them, can be used in methods to treat subjects, to alter CAR-expressing cells in subjects who may suffer from a disease such as a cancer or a pathogen.

公开(公告)号：WO2018187190A1

公开(公告)日：2018-10-11

申请号：PCT/US2018/025621

申请日：2018-04-02

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.

发明人： GOLDSTEIN, Harris ,  ALMO, Steven, C.

IPC分类号： C12N5/0783 ,  C12N15/13 ,  C12N15/85 ,  C12N15/86 ,  C12N15/867 ,  C07K14/47 ,  C07K14/74 ,  C07K16/28 ,  C07K14/725 ,  C07K14/705

CPC分类号： C07K16/2818 ,  A61P31/18 ,  C07K14/005 ,  C07K14/52 ,  C07K14/5418 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/70521 ,  C07K14/70532 ,  C07K14/70539 ,  C07K14/70596 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2319/30 ,  C12N2710/16122 ,  C12N2740/16043 ,  C12N2740/16222

摘要： Compositions and methods to increase the in vivo capacity of CD8+ T cells to kill HIV-infected and reactivated latent HIV-infected T cells (LHITC) to functionally cure HIV infection or improve the clinical course. Compositions and methods to increase the in vivo capacity of CD8+ T cells to kill CMV or CMV -infected cells are also provided.

公开(公告)号：WO2006096656A2

公开(公告)日：2006-09-14

申请号：PCT/US2006/007961

申请日：2006-03-06

申请人： ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY ,  DADACHOVA, Ekaterina ,  CASADEVALL, Arturo ,  GOLDSTEIN, Harris

发明人： DADACHOVA, Ekaterina ,  CASADEVALL, Arturo ,  GOLDSTEIN, Harris

IPC分类号： A61K51/00

CPC分类号： A61K51/1006

摘要： This invention provides methods for treating subjects infected with human immunodeficiency virus (HIV) which comprise administering to the subjects a radiolabeled antibody or agent effective to kill HIV infected cells, where the antibody or agent is specific for a HIV envelope glycoprotein. The invention also provides compositions and methods for making compositions of radiolabeled antibodies or agents to HIV envelope glycoproteins for treatment of HIV infection.

摘要翻译： 本发明提供了治疗感染人免疫缺陷病毒（HIV）的受试者的方法，其包括向受试者施用有效杀死HIV感染细胞的放射性标记的抗体或试剂，其中抗体或试剂对HIV包膜糖蛋白是特异性的。 本发明还提供了用于制备放射性标记的抗体或HIV包膜糖蛋白的试剂的组合物用于治疗HIV感染的组合物和方法。