公开(公告)号：WO2015161306A1

公开(公告)日：2015-10-22

申请号：PCT/US2015/026555

申请日：2015-04-18

Applicant: ALCYONE LIFESCIENCES, INC.

Inventor： EAST, Andrew ,  BROPHY, Morgan ,  SINGH, Deep, Arjun ,  ANAND, PJ ,  DEGON, Robert ,  FALLON, Timothy ,  WALLER, Allison ,  ATTAR, Matthew

IPC: A61M27/00

CPC classification number: A61M27/006 ,  A61M39/225 ,  A61M2027/004 ,  A61M2039/0018

Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRI)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRI, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system are also disclosed herein, as are various systems and methods for opening auxiliary fluid pathways through a shunt system.

Abstract translation: 本文提供的系统和方法通常涉及分流流体，例如在治疗脑积水时分流脑脊液。 提供了自清洁导管，其包括分开的尖端，其被配置为使得在其中插入导管的空腔中的脉动流动可导致尖端彼此撞击，从而清除障碍物。 还提供了内置流量指示器的导管。 示例性的流动指示器包括从导管的内表面径向向内延伸并且包括可成像部分（例如，在磁共振成像（MRI）下可见的部分）的突出部。 可以使用MRI检测由流体流过导管引起的流动指示器的运动，从而提供导管是否部分或完全阻塞的可靠指示。 本文还公开了用于冲洗分流系统的系统和方法，以及用于打开通过分流系统的辅助流体路径的各种系统和方法。

公开(公告)号：WO2014116640A1

公开(公告)日：2014-07-31

申请号：PCT/US2014/012449

申请日：2014-01-22

Applicant: ALCYONE LIFESCIENCES, INC.

Inventor： ANAND, Pj ,  SINGH, Deep, Arjun ,  BROPHY, Morgan ,  FALLON, Timothy ,  DEGON, Robert ,  ATTAR, Matthew ,  WONG, Anthony ,  WALLER, Allison ,  EAST, Andrew ,  MCINTYRE, Jon, T.

IPC: A61M25/14 ,  A61B17/22 ,  A61B18/24

CPC classification number: A61M27/006 ,  A61M39/225 ,  A61M2025/0019 ,  A61M2039/0018 ,  A61M2205/0205 ,  A61M2205/32 ,  A61M2205/3344 ,  A61M2230/20

Abstract: Systems and methods are provided herein that generally involve shunting fluid, e.g., shunting cerebrospinal fluid in the treatment of hydrocephalus. Self-cleaning catheters are provided which include split tips configured such that pulsatile flow of fluid in a cavity in which the catheter is inserted can cause the tips to strike one another and thereby clear obstructions. Catheters with built-in flow indicators are also provided. Exemplary flow indicators include projections that extend radially inward from the interior surface of the catheter and which include imageable portions (e.g., portions which are visible under magnetic resonance imaging (MRl)). Movement of the flow indicators caused by fluid flowing through the catheter can be detected using MRl, thereby providing a reliable indication as to whether the catheter is partially or completely blocked. Systems and methods for flushing a shunt system and for opening auxiliary fluid pathways through a shunt system are also disclosed herein.

Abstract translation: 本文提供的系统和方法通常涉及分流流体，例如在治疗脑积水时分流脑脊液。 提供了自清洁导管，其包括分开的尖端，其被配置为使得在其中插入导管的空腔中的脉动流动可导致尖端彼此撞击，从而清除障碍物。 还提供了内置流量指示器的导管。 示例性流量指示器包括从导管的内表面径向向内延伸并且包括可成像部分（例如在磁共振成像（MR1）下可见的部分））的突起。 可以使用MR1检测由流体流过导管引起的流动指示器的运动，从而提供关于导管是部分地还是完全阻塞的可靠指示。 本文还公开了用于冲洗分流系统和用于打开通过分流系统的辅助流体路径的系统和方法。