公开(公告)号：WO02098389A8

公开(公告)日：2006-10-12

申请号：PCT/US0215425

申请日：2002-05-13

Applicant: ALEXZA MOLECULAR DELIVERY CORP

Inventor： HALE RON L ,  HODGES CRAIG C ,  LLOYD PETER M ,  MUFSON DANIEL ,  ROGERS DANIEL D ,  SONG SOONHO ,  WENSLEY MARTIN J ,  MYERS DANIEL J ,  MCKINNEY JEFFREY A ,  QUINTANA REYNALDO J ,  RABINOWITZ JOSHUA D

IPC: A61K9/72 ,  A61M15/00 ,  A61K9/00 ,  A61K9/16 ,  A61K31/4468 ,  A61M11/00 ,  A61M11/04 ,  A61M16/00 ,  A61P23/00 ,  B05B7/16 ,  B05B17/04

CPC classification number: A61M11/044 ,  A61K9/007 ,  A61K9/0073 ,  A61K31/235 ,  A61K31/4468 ,  A61K31/485 ,  A61K31/519 ,  A61M11/001 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0028 ,  A61M16/109 ,  A61M2016/0039 ,  A61M2205/3606 ,  A61M2205/3653 ,  A61M2205/368 ,  A61M2205/50 ,  B05B7/1686 ,  B05B17/04

Abstract: The present invention relates to the inhalation delivery of aerosols containing small particles. Specifically, it relates to a method of forming an aerosol for use in inhalation therapy. In a method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug at a rate greater than 1000 °C/s, thereby forming an vapor; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor, wherein the coated composition is in the form of a film less than 10 µ thick; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy. In another method aspect of the present invention, a method of forming an aerosol for use in inhalation therapy is provided. The method involves the following steps: (a) heating a substrate coated with a composition comprising a drug to form a vapor in less than 100 milliseconds, wherein the vapor has a mass greater than 0.1 mg; and, (b) allowing the vapor to cool, thereby forming an aerosol, which is used in inhalation therapy.

Abstract translation: 本发明涉及含有小颗粒的气溶胶的吸入输送。 具体地说，本发明涉及形成用于吸入治疗的气雾剂的方法。 在本发明的方法方面，提供了一种形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）以大于1000℃/ s的速率加热涂覆有包含药物的组合物的基底，从而形成蒸气; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以形成蒸气，其中所述涂覆的组合物为小于10μm的膜的形式; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。 在本发明的另一方法方面，提供了形成用于吸入治疗的气雾剂的方法。 该方法包括以下步骤：（a）加热涂覆有包含药物的组合物的基底以在小于100毫秒内形成蒸气，其中蒸气的质量大于0.1mg; 和（b）允许蒸汽冷却，从而形成用于吸入治疗的气溶胶。