公开(公告)号：WO2020047424A1

公开(公告)日：2020-03-05

申请号：PCT/US2019/049087

申请日：2019-08-30

Applicant: AMGEN, INC.

Inventor： CAILLE, Sebastien ,  CORBETT, Michael ,  SMITH, Austin

IPC: A61K31/45 ,  C07D211/76 ,  C07D471/04 ,  C07D498/04

Abstract: The present invention provides commercial processes for preparing 2- ((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3 -m ethyl-2-oxopiperi din-3 -yl)acetic acid as well as intermediates thereof.

公开(公告)号：WO2020047424A9

公开(公告)日：2020-03-05

申请号：PCT/US2019/049087

申请日：2019-08-30

Applicant: AMGEN, INC.

Inventor： CAILLE, Sebastien ,  CORBETT, Michael ,  SMITH, Austin

IPC: A61K31/45 ,  C07D211/76 ,  C07D471/04 ,  C07D498/04

Abstract: The present invention provides commercial processes for preparing 2- ((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-l-((S)-l-(isopropylsulfonyl)-3-methylbutan-2-yl)-3 -m ethyl-2-oxopiperi din-3 -yl)acetic acid as well as intermediates thereof.