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1.发明申请
公开(公告)号：WO2022232083A1
公开(公告)日：2022-11-03
申请号：PCT/US2022/026261
申请日：2022-04-26
Applicant: AMGEN INC.
Inventor： ZHANG, Li , BARKHORDARIAN, Hedieh , ZASADZINSKA, Ewelina , DIEP, Jonathan
Abstract: The present invention relates to the field of biopharmaceutical manufacturing. In particular, the invention relates to using temperature as a lever to modulate product quality during upstream operations.
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公开(公告)号：WO2022140344A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064546
申请日：2021-12-21
Applicant: AMGEN INC.
Inventor： TAN, Glenn, Christopher , ZASADZINSKA, Ewelina , HOFFMANN, Patrick , WU, Bin
IPC: C12N5/00 , B01L3/00 , C12M1/00 , G01N21/64 , B01L2200/0668 , B01L2300/0896 , C12N5/0075
Abstract: The present disclosure provides materials and methods identifying, selecting, and characterizing cells that express and secrete non-Fc containing biomolecules.
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公开(公告)号：WO2022066418A1
公开(公告)日：2022-03-31
申请号：PCT/US2021/049562
申请日：2021-09-09
Applicant: AMGEN INC.
Inventor： LE, Huong, Thi Ngoc , TAT, Jasmine , ZASADZINSKA, Ewelina
Abstract: Methods and systems for determining a minimum number of cell line clones necessary to produce a product having a set of target product attributes are disclosed. An example method includes generating at least one cell line capable of expressing a polypeptide; measuring, using one or more analytical instruments, a plurality of measured product attribute values of a plurality of clones of a candidate cell line; receiving inputs, via a user interface, representing a set of target product attribute values for a product; projecting, by one or more processors based upon the plurality of measured values, a minimum number of subject clones of the product using the candidate cell line necessary to produce a subset of the subject clones having product attributes that satisfy one or more conditions associated with the set of target values; and generating the projected minimum number of subject clones of the product using the candidate cell line.
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