公开(公告)号：WO2022269351A2

公开(公告)日：2022-12-29

申请号：PCT/IB2022/000349

申请日：2022-06-21

Applicant: BIO-CHANGE LTD.

Inventor： ATTAR, Ishay ,  KEREN, Sinik ,  COHEN, Shani

IPC: A61K38/06 ,  A61K38/12 ,  A23C9/152 ,  C08H1/00 ,  A61K9/19 ,  A61L26/00 ,  C12N2533/30 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2533/78 ,  C12N2533/80 ,  C12N5/0062 ,  C12N5/0075

Abstract: Embodiments of the present disclosure relate to particles, compositions, tissue scaffolds, apparatuses, and uses and methods thereof for body contouring, tissue engineering, regenerative medicine, aesthetic dermatology, and reconstructive procedures or surgery.

公开(公告)号：WO2022140344A1

公开(公告)日：2022-06-30

申请号：PCT/US2021/064546

申请日：2021-12-21

Applicant: AMGEN INC.

Inventor： TAN, Glenn, Christopher ,  ZASADZINSKA, Ewelina ,  HOFFMANN, Patrick ,  WU, Bin

IPC: C12N5/00 ,  B01L3/00 ,  C12M1/00 ,  G01N21/64 ,  B01L2200/0668 ,  B01L2300/0896 ,  C12N5/0075

Abstract: The present disclosure provides materials and methods identifying, selecting, and characterizing cells that express and secrete non-Fc containing biomolecules.

公开(公告)号：WO2022240910A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028637

申请日：2022-05-10

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA ,  BLOCK, David ,  NITIN, Nitin

Inventor： OGAWA, Minami

IPC: C12N1/14 ,  A23L13/00 ,  C12N5/00 ,  C12R1/66 ,  C12R1/80 ,  C12R1/845 ,  A23L13/424 ,  A23L31/00 ,  C12N2502/70 ,  C12N5/0062 ,  C12N5/0075 ,  C12N5/0656 ,  C12N5/0658 ,  C12R2001/66 ,  C12R2001/80 ,  C12R2001/845

Abstract: Set forth herein is a composition that includes a fungal pellet and animal cells, wherein the animal cells are in connection with the fungal pellet. The animal cells can be located on the exterior surface of the fungal pellet, the interior of the fungal pellet, or both. The fungal pellet can include intact fungal cells. The fungal pellet can be substantially inviable. In an example, the pellet can be heat-treated, chemically treated, or lyophilized. The animal cells can be mammalian cells, wherein the mammalian cells may be non-human mammalian cells.

公开(公告)号：WO2021123878A1

公开(公告)日：2021-06-24

申请号：PCT/IB2019/060937

申请日：2019-12-17

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： WLASCHIN, Katie F. ,  SGOLASTRA, Federica ,  NAKAMURA, Masayuki

IPC: C12N11/14 ,  C12N5/00 ,  C12M1/12 ,  B01J20/10 ,  B01J20/28 ,  B01J20/103 ,  B01J20/28021 ,  B01J20/3204 ,  B01J20/3219 ,  B01J20/3248 ,  B01J20/3257 ,  B01J20/3274 ,  C12M25/16 ,  C12N2533/12 ,  C12N5/0075

Abstract: A composition and a method for culturing cells. The composition includes a plurality of buoyant hollow particles, the buoyant hollow particles comprising a siliceous surface; and a plurality of mammalian cells attached to the siliceous surface of the buoyant hollow particles; wherein the buoyant hollow particles are less dense than a media; and wherein the average seeding density is 3-50 adherent cells/buoyant hollow particle.

公开(公告)号：WO2021255008A1

公开(公告)日：2021-12-23

申请号：PCT/EP2021/066071

申请日：2021-06-15

Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V.

Inventor： ZIMMERMANN, Heiko ,  NEUBAUER, Julia ,  GEPP, Michael

IPC: C12N5/00 ,  C12N2531/00 ,  C12N2533/74 ,  C12N5/0075

Abstract: Ein Verfahren zur Herstellung von Trägerpartikeln für die Kultivierung biologischer Zellen umfasst die Schritte Bereitstellung einer wässrigen Suspension von Hydrogel-Kügelchen und Gefriertrocknung der Hydrogel-Kügelchen, so dass trockene Hydrogel-Partikel gebildet werden, wobei der Suspension mindestens eine Lyoprotektant-Substanz zugesetzt wird, die Hydrogel-Kügelchen in der Suspension mit der Lyoprotektant-Substanz beladen werden und die trockenen Hydrogel-Partikel unter der Wirkung der Lyoprotektant-Substanz eine Form erhalten, welche an eine sphärische Partikelform angenähert ist und auch nach der Rehydratisierung erhalten bleibt. Es werden auch Trägerpartikel für eine Kultivierung biologischer Zellen, die trockene Hydrogel-Partikel, vorzugsweise mit einer Proteinbeschichtung, umfassen, und Anwendungen der Trägerpartikel beschrieben.

公开(公告)号：WO2021229241A1

公开(公告)日：2021-11-18

申请号：PCT/GB2021/051168

申请日：2021-05-14

Applicant: LIGHTCAST DISCOVERY LTD

Inventor： MACIEJ, Sosna ,  EVANGELIA-NEFELI, Athanasopoulou ,  MEI, Wu

IPC: B01L3/00 ,  C12M3/02 ,  C12N5/00 ,  B01L2200/0652 ,  B01L3/502761 ,  B01L3/502792 ,  C12M25/01 ,  C12N2521/00 ,  C12N5/0075

Abstract: 32 ABSTRACT A method of handling an adherent cell in a microdroplet assaying system by conjugating an adherent cell to a microbead is provided. The method 50 comprises the steps of: loading a first plurality of microdroplets into a microfluidic space, wherein each of the first microdroplet 5 contains a microbead 52 and a first fluid; loading a second plurality of microdroplets into the microfluidic space, wherein each of the second microdroplet contains an adherent cell and a second fluid 54; merging the first plurality of microdroplets and the second plurality of microdroplets to form a plurality of merged microdroplets 56, each merged microdroplets containing the first and second fluids, at least one microbead and at least one adherent cell; and10 agitating each of the merged microdroplets 58 to cause the first and second fluids in each of the merged microdroplets to move such that at least one adherent cell adhere to the at least one microbead. [Figure 1]15

公开(公告)号：WO2021140129A1

公开(公告)日：2021-07-15

申请号：PCT/EP2021/050143

申请日：2021-01-06

Applicant: CARROUCELL

Inventor： FATHALLAH, Tarek

IPC: C12M1/12 ,  C12N5/00 ,  C12M25/16 ,  C12N5/0075

Abstract: Procédé de formation de microporteurs (1), comportant: a) formation de gouttes liquides (12) à partir d'une solution sol-gel (2); b) dépôts des gouttes, sous forme de liquide, sur un premier support (10), de préférence hydrophobe; c) déformation des gouttes déposées sur le premier support (10); d) solidification des gouttes par gélification et séchage, de façon à former des microporteurs solides; e) extraction des microporteurs solidifiés du premier support (10).