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公开(公告)号：WO2017091656A1
公开(公告)日：2017-06-01
申请号：PCT/US2016/063480
申请日：2016-11-23
申请人： AMGEN INC. , XENCOR, INC.
发明人： STEVENS, Jennitte, Leann , BALAZS, Mercedesz , NOLAN-STEVAUX, Olivier , MOORE, Gregory , DESJARLAIS, John , BERNETT, Matthew, J. , CHU, Seung, Y. , RASHID, Rumana , MUCHHAL, Umesh
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/18 , C07K16/2809 , C07K16/2896 , C07K16/3061 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/92
摘要： The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
摘要翻译： 本发明涉及结合CD3和CD38的异二聚体抗体。
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公开(公告)号：WO2017091656A8
公开(公告)日：2017-06-01
申请号：PCT/US2016/063480
申请日：2016-11-23
申请人： AMGEN INC. , XENCOR, INC.
发明人： STEVENS, Jennitte, Leann , BALAZS, Mercedesz , NOLAN-STEVAUX, Olivier , MOORE, Gregory , DESJARLAIS, John , BERNETT, Matthew, J. , CHU, Seung, Y. , RASHID, Rumana , MUCHHAL, Umesh
摘要： The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.
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公开(公告)号：WO2021067863A2
公开(公告)日：2021-04-08
申请号：PCT/US2020/054139
申请日：2020-10-02
申请人： XENCOR, INC. , HEDVAT, Michael , CHANG, Eric
发明人： BERNETT, Matthew , DESJARLAIS, John, R. , VARMA, Rajat , LIU, Ke , RASHID, Rumana , HASSANZADEH-KIABI, Nargess
IPC分类号： A61K38/00 , A61K39/395 , A61P35/00 , C07K14/54 , C07K16/28 , C07K14/5434 , C07K16/2818 , C07K16/2827 , C07K2317/24 , C07K2317/33 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/92 , C07K2319/30 , C07K2319/33
摘要： The present invention relates to targeted IL-12 heterodimeric Fc fusion proteins, where the fusion proteins bind to human PD-1 or human PD- L1.
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4.发明申请
公开(公告)号：WO2019204655A1
公开(公告)日：2019-10-24
申请号：PCT/US2019/028192
申请日：2019-04-18
申请人： XENCOR, INC.
摘要： The present invention is directed to novel targeted heterodimeric fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a TIM-3 antibody fragment-Fc fusion protein.
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公开(公告)号：WO2020172631A2
公开(公告)日：2020-08-27
申请号：PCT/US2020/019363
申请日：2020-02-21
申请人： XENCOR, INC.
发明人： MOORE, Gregory , VARMA, Rajat , KIM, Yoon, Kyung , RASHID, Rumana , CHANG, Eric , NISTHAL, Alex , DIAZ, Juan , BERNETT, Matthew , HEDVAT, Michael
摘要： The present invention provides untargeted and targeted IL-10-Fc fusion proteins, compositions and methods of use thereof. The targeted IL-10-Fc fusion proteins includes those that bind PD-1, TIGIT, CDS and NKG2D.
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6.发明申请
公开(公告)号：WO2019204646A9
公开(公告)日：2019-10-24
申请号：PCT/US2019/028180
申请日：2019-04-18
申请人： XENCOR, INC.
摘要： The present invention is directed to novel targeted heterodimeric fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a LAG-3 antibody fragment-Fc fusion protein.
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公开(公告)号：WO2018005706A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/039840
申请日：2017-06-28
申请人： XENCOR, INC.
发明人： MOORE, Gregory , RASHID, Rumana , LEE, Sung-Hyung , FOSTER, Paul
摘要： The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2).
摘要翻译： 本发明涉及结合生长抑素受体2（SSTR2）的抗体，包括新型抗原结合结构域和异源二聚体抗体。
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公开(公告)号：WO2021072298A1
公开(公告)日：2021-04-15
申请号：PCT/US2020/055116
申请日：2020-10-09
申请人： GENENTECH, INC. , XENCOR, INC.
发明人： DESJARLAIS, John , BERNETT, Matthew , HEDVAT, Michael , VARMA, Rajat , SCHUBBERT, Suzanne , BONZON, Christine , RASHID, Rumana , DIAZ, Juan , HOLDER, Patrick , HUANG, Christine
IPC分类号： A61K39/395 , A61P35/00 , C07K14/54 , C07K14/715 , C07K16/08 , C07K16/28 , A61K39/00
摘要： The present invention relates to fusion proteins comprising variant IL-15 proteins, fusion proteins comprising variant anti-PD-1 antigen binding domains, and fusion proteins comprising variant IL-15 proteins and variant anti-PD-1 antigen binding domains. The present invention also relates to nucleic acid molecules, expression vectors, host cells and methods for making such fusion proteins and the use of such fusion proteins in the treatment of cancer.
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9.发明申请
公开(公告)号：WO2020132646A1
公开(公告)日：2020-06-25
申请号：PCT/US2019/068167
申请日：2019-12-20
申请人： XENCOR, INC.
发明人： BERNETT, Matthew , DESJARLAIS, John, R. , VARMA, Rajat , MOORE, Gregory , DIAZ, Juan , NISTHAL, Alex , LIU, Ke , RASHID, Rumana , CHANG, Eric
摘要： The present invention is directed to a novel targeted heterodimeric Fc fusion proteins comprising an IL-l5/IL-l5Rα Fc fusion protein and an NKG2D antigen binding domain Fc fusion proteins.
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10.发明申请
公开(公告)号：WO2019204655A9
公开(公告)日：2019-10-24
申请号：PCT/US2019/028192
申请日：2019-04-18
申请人： XENCOR, INC.
摘要： The present invention is directed to novel targeted heterodimeric fusion proteins comprising an IL-15/IL-15Rα Fc-fusion protein and a TIM-3 antibody fragment-Fc fusion protein.
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