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公开(公告)号：WO2018141910A1
公开(公告)日：2018-08-09
申请号：PCT/EP2018/052665
申请日：2018-02-02
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor： MCAULEY, Arnold , GHATTYVENKATAKRISHNA, Pavan , ABEL, Jeff , HUH, Joon , POMPE, Cornelius , KANAPURAM, Sekhar , TREUHEIT, Michael , JAGANNATHAN, Bharadwaj
IPC: A61K39/395 , C07K16/28
Abstract: The present disclosure provides a low pH pharmaceutical composition comprising (a) an antibody constructs comprising a first domain binding to a target cell surface antigen, a second domain binding to a second antigen and preferably a third domain, which is a specific Fc modality, (b) at least one buffer agent, (c) at least one saccharide, and (d) at least one surfactant; and wherein the pH of the pharmaceutical composition is in the range of 3.5 to 6.
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Patent Agency Ranking
公开(公告)号：WO2017134134A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052202
申请日：2017-02-02
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
IPC: C07K16/28
CPC classification number: C07K16/2878 , A61K2039/505 , C07K16/2809 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/56 , C07K2317/622 , C07K2317/64 , C07K2317/94 , C07K2319/00
Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to BCMA, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
Abstract translation: 本发明提供了特异性Fc模式的双特异性抗体构建体，其特征在于包含与BCMA结合的第一结构域，与人和/或猕猴CD3ε链的细胞外表位结合的第二结构域和 第三个领域，这是特定的Fc模式。 此外，本发明提供了编码抗体构建体的多核苷酸，包含该多核苷酸的载体，表达构建体的宿主细胞以及包含其的药物组合物。
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3.发明申请
公开(公告)号：WO2017129585A1
公开(公告)日：2017-08-03
申请号：PCT/EP2017/051486
申请日：2017-01-25
Applicant: AMGEN RESEARCH (MUNICH) GMBH , AMGEN INC.
Inventor： KANAPURAM, Sekhar , LATYPOV, Ramil , THANGARAJ, Balakumar , POMPE, Cornelius
IPC: C07K16/28 , A61K39/395 , A61K47/00
CPC classification number: A61K39/3955 , A61K9/0019 , A61K9/1652 , A61K9/19 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/40 , A61K2039/505 , B01D61/145 , B01D2315/16 , C07K16/2803 , C07K16/2809 , C07K16/2878 , C07K2317/24 , C07K2317/31 , C07K2317/622 , C07K2317/94
Abstract: The present invention provides novel and stable pharmaceutical compositions comprising bispecific single chain antibody constructs, cyclodextrins and a buffer.
Abstract translation: 本发明提供了包含双特异性单链抗体构建体，环糊精和缓冲液的新颖且稳定的药物组合物。
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公开(公告)号：WO2017134140A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052212
申请日：2017-02-02
Applicant: AMGEN RESEARCH (MUNICH) GMBH
Inventor： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
CPC classification number: C07K16/30 , C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/3053 , C07K16/468 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/64 , C07K2317/94 , C07K2319/00
Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to a target cell surface antigen, a second domain binding to an extracellular epitope of the human and/or the Macaca CD3ε chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
Abstract translation: 本发明提供了特异性Fc模式的双特异性抗体构建体，其特征在于包含与靶细胞表面抗原结合的第一结构域，与人和/或猕猴的细胞外表位结合的第二结构域 CD3ε链和第三个结构域，这是特定的Fc模式。 此外，本发明提供了编码抗体构建体的多核苷酸，包含该多核苷酸的载体，表达构建体的宿主细胞以及包含其的药物组合物。
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公开(公告)号：WO2017134158A1
公开(公告)日：2017-08-10
申请号：PCT/EP2017/052239
申请日：2017-02-02
Applicant: AMGEN RESEARCH (MUNICH) GMBH
Inventor： RAUM, Tobias , MUENZ, Markus , BROZY, Johannes , KUFER, Peter , HOFFMANN, Patrick , FRIEDRICH, Matthias , RATTEL, Benno , BOGNER, Pamela , WOLF, Andreas , POMPE, Cornelius
CPC classification number: C07K16/3069 , A61K2039/505 , C07K16/2809 , C07K2317/31 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/622 , C07K2317/64
Abstract: The present invention provides bispecific antibody constructs of a specific Fc modality characterized by comprising a first domain binding to PSMA, a second domain binding to an extracellular epitope of the human and the Macaca CD3 E chain and a third domain, which is the specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.
Abstract translation: 本发明提供了特异性Fc模式的双特异性抗体构建体，其特征在于包含与PSMA结合的第一结构域，与人的细胞外表位结合的第二结构域和 猕猴CD3_E链和第三个结构域，它是特定的Fc模式。 此外，本发明提供了编码抗体构建体的多核苷酸，包含该多核苷酸的载体，表达构建体的宿主细胞以及包含其的药物组合物。
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公开(公告)号：WO2021081321A1
公开(公告)日：2021-04-29
申请号：PCT/US2020/057054
申请日：2020-10-23
Applicant: AMGEN INC.
Inventor： POMPE, Cornelius , CLARK, Nicholas, J. , QI, Wei , MCAULEY, Arnold, J. , SCHNEIDER, Michael , WU, Chia-Jung , CHRISTIAN, Twinkle, R. , FRANEY, Heather, N. , JAGANNATHAN, Bharadwaj , ABEL, Jeffrey , DIETZEL, Franz
Abstract: An approach for determining material compatibility for components of a drug delivery system is provided that includes using surface zeta-potential analytical method to evaluate surface interactions between a desired molecule and at least one material present within a given IV-bag system.
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