公开(公告)号：WO2014121205A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014466

申请日：2014-02-03

Applicant: AUXOGYN, INC.

Inventor： SHEN, Shehua ,  CHEN KIM, Alice, A. ,  WIRKA, Kelly, Athayde ,  SURAJ, Vaishali ,  TAN, Lei

IPC: G01N33/48

CPC classification number: G01N33/5091 ,  G01N2800/367 ,  G06F19/00 ,  G06K9/00134 ,  G06K9/00147

Abstract: Infertility is a common health problem that affects 10-15% of couples of reproductive age. In the United States alone in the year 2006, approximately 140,000 cycles of in vitro fertilization (IVF) were performed. This resulted in the culture of more than a million embryos annually with variable, and often ill-defined, potential for implantation and development to temi. The live birth rate, per cycle, following IVF was just 29%, while on average 30% of live births resulted in multiple gestations. Multiple gestations have well-documented adverse outcomes for both the mother and fetuses, such as miscarriage, preterm birth, and low birth rate.

Abstract translation: 不孕是一个常见的健康问题，影响10-15％的育龄夫妇。 仅在2006年的美国，进行了约14万个体外受精（IVF）的周期。 这导致每年有超过一百万个胚胎的培养，具有植入和发育趋势的变化，往往不明确的潜力。 在IVF之后的每个周期的活产率只有29％，而平均30％的活产婴儿导致多次妊娠。 母亲和胎儿的多胎妊娠记录有不良后果，如流产，早产和低出生率。

公开(公告)号：WO2015143350A1

公开(公告)日：2015-09-24

申请号：PCT/US2015/021796

申请日：2015-03-20

Applicant: AUXOGYN, INC.

Inventor： TAN, Lei ,  CHIAN, Martin ,  CHEN KIM, Alice ,  LORENZEN, Peter

IPC: G06K9/00 ,  G06T7/00 ,  G01N33/50 ,  G01N33/483 ,  C12N5/073

CPC classification number: G01N33/5091 ,  C12N5/0604 ,  G01N15/1463 ,  G01N33/4833 ,  G01N2015/1493 ,  G01N2015/1497 ,  G06K9/00147 ,  G06T7/0016 ,  G06T2207/10056 ,  G06T2207/30044

Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans.

Abstract translation: 提供了用于确定一种或多种胚胎的发育潜力的方法，组合物和试剂盒。 这些方法，组合物和试剂盒可用于鉴定在人体内治疗不育症中最有用的体外胚胎。

公开(公告)号：WO2014121200A1

公开(公告)日：2014-08-07

申请号：PCT/US2014/014449

申请日：2014-02-03

Applicant: AUXOGYN, INC.

Inventor： SHEN, Shehua ,  CHEN KIM, Alice, A. ,  WIRKA, Kelly, Athayde ,  SURAJ, Vaishali ,  TAN, Lei

IPC: A61B17/43 ,  A61D7/00

CPC classification number: G01N33/5091 ,  G01N2800/367

Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans.

Abstract translation: 提供了用于确定一种或多种胚胎的发育潜力的方法，组合物和试剂盒。 这些方法，组合物和试剂盒可用于鉴定在人体内治疗不育症中最有用的体外胚胎。