公开(公告)号：WO2021007141A8

公开(公告)日：2021-01-14

申请号：PCT/US2020/040856

申请日：2020-07-06

Applicant: BASF CORPORATION ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： REISMAN, Sarah ,  ROMBOLA, Michael ,  LADD, Carolyn, L. ,  MCLAUGHLIN, Martin, John ,  ZUEND, Stephan ,  GOETZ, Roland

IPC: C07D401/14 ,  C07B53/00 ,  C07C35/18 ,  C07B2200/07 ,  C07C201/12 ,  C07C2601/16 ,  C07C2602/44 ,  C07C2603/74 ,  C07C67/293

Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a', R10b', R10c', R10d', Z and Z' have the meanings as defined in the description.

公开(公告)号：WO2021007141A1

公开(公告)日：2021-01-14

申请号：PCT/US2020/040856

申请日：2020-07-06

Applicant: BASF CORPORATION ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： REISMAN, Sarah ,  ROMBOLA, Michael ,  LADD, Carolyn, L. ,  MCLAUGHLIN, Martin, John ,  ZUEND, Stephan ,  GOETZ, Roland

IPC: C07D401/14 ,  C07B53/00 ,  C07C35/18

Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a' , R 10b' , R 10c' , R 10d' , Z and Z' have the meanings as defined in the description.

公开(公告)号：WO2017106649A1

公开(公告)日：2017-06-22

申请号：PCT/US2016/067181

申请日：2016-12-16

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： CHUANG, Kangway, V. ,  XU, Chen ,  REISMAN, Sarah

IPC: C07D311/94 ,  C07D309/30 ,  A61K31/35 ,  A61K31/366

CPC classification number: C07D309/30 ,  C07C43/23 ,  C07C43/315 ,  C07C49/577 ,  C07C49/743 ,  C07C49/753 ,  C07D309/32

Abstract: This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogues thereof and novel compounds prepared thereby.

Abstract translation: 本公开涉及用于生产脱水安奈多，ryanodol或其类似物以及由此制备的新化合物的方法。