公开(公告)号：WO2020223538A8

公开(公告)日：2020-11-05

申请号：PCT/US2020/030819

申请日：2020-04-30

Applicant: CALICO LIFE SCIENCES LLC ,  ABBVIE INC.

Inventor： MARTIN, Kathleen, Ann ,  SIDRAUSKI, Carmela ,  SHI, Lei ,  MURAUSKI, Kathleen, J. ,  XU, Xiangdong ,  TONG, Yunsong ,  RANDOLPH, John, T. ,  DART, Michael, J. ,  BENELKEBIR, Hanae ,  EDESON, Steven ,  STARBUCK, Kathryn

IPC: C07D311/74 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00 ,  C07C1/00 ,  C07D213/53 ,  C07D265/36 ,  C07D271/10 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D407/12 ,  C07D413/04 ,  C07D413/12 ,  C07D417/12 ,  A61K31/165 ,  A61K31/353 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/4433 ,  A61K45/06 ,  A61P25/28 ,  C07C235/22 ,  C07C235/36 ,  C07C235/40 ,  C07C2601/04 ,  C07C2602/38 ,  C07C2602/44 ,  C07D311/22 ,  C07D311/24 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08

Abstract: Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.

公开(公告)号：WO2021124272A1

公开(公告)日：2021-06-24

申请号：PCT/IB2020/062218

申请日：2020-12-18

Applicant: LIMINAL BIOSCIENCES LIMITED

Inventor： GAGNON, Lyne ,  LEBLOND, François ,  GEERTS, Lilianne ,  ZACHARIE, Boulos ,  DOYLE, Chris ,  MARTEL, Julien ,  DUCEPPE, Jean-Simon ,  LACOSTE, Jean-Eric ,  THIBODEAU, Jean-François

IPC: A61P3/04 ,  A61P3/10 ,  A61P7/06 ,  A61P9/12 ,  A61P35/00 ,  C07C53/134 ,  C07C57/26 ,  C07D303/12 ,  C07B2200/05 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2602/44 ,  C07C53/23 ,  C07C61/04 ,  C07C61/16

Abstract: The present application discloses a compound of formula (I) or a salt thereof: (I) and compositions comprising such compound or salt thereof. The use of such compound, salt thereof or composition comprising same for treating anemia or leukopenia, fibrosis, cancer, hypertension and/or a metabolic condition in a subject is also disclosed.

公开(公告)号：WO2023273846A1

公开(公告)日：2023-01-05

申请号：PCT/CN2022/098281

申请日：2022-06-11

Applicant: 四川阿格瑞新材料有限公司

Inventor： 鄢亮亮 ,  陈少福 ,  戴雷 ,  蔡丽菲

IPC: C07C211/61 ,  H01L51/54 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/24 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2603/18 ,  C07C2603/94 ,  C07D209/86 ,  C07D307/14 ,  C07D307/91 ,  C07D309/04 ,  H01L51/0052 ,  H01L51/0056 ,  H01L51/006 ,  H01L51/0061 ,  H01L51/0065 ,  H01L51/0072 ,  H01L51/0073 ,  H01L51/5056 ,  H01L51/5088

Abstract: 涉及一种式(1)所示的螺环化合物及其应用。该螺环化合物具有光、电稳定性高，升华温度低，驱动电压低，载流子横向迁移率小，发光效率高，器件寿命长等优点，可用于有机电致发光器件中。特别是作为空穴注入、传输类材料，具有应用于AMOLED产业的可能。

公开(公告)号：WO2021007141A8

公开(公告)日：2021-01-14

申请号：PCT/US2020/040856

申请日：2020-07-06

Applicant: BASF CORPORATION ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： REISMAN, Sarah ,  ROMBOLA, Michael ,  LADD, Carolyn, L. ,  MCLAUGHLIN, Martin, John ,  ZUEND, Stephan ,  GOETZ, Roland

IPC: C07D401/14 ,  C07B53/00 ,  C07C35/18 ,  C07B2200/07 ,  C07C201/12 ,  C07C2601/16 ,  C07C2602/44 ,  C07C2603/74 ,  C07C67/293

Abstract: This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation Mm+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R10a, R10b, R10c, R10d, R10a', R10b', R10c', R10d', Z and Z' have the meanings as defined in the description.