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    GENERATION OF HPV-SPECIFIC T-CELLS
    1.
    发明申请
    GENERATION OF HPV-SPECIFIC T-CELLS 审中-公开
    生成HPV特异性T细胞

    公开(公告)号：WO2018050818A1

    公开(公告)日：2018-03-22

    申请号：PCT/EP2017/073274

    申请日：2017-09-15

    申请人： BAYLOR COLLEGE OF MEDICINE ,  CLEGG, Richard Ian

    发明人： RAMOS, Carlos A. ,  ROONEY, Cliona M. ,  NARALA, Neeharika

    IPC分类号： C12N5/0783

    摘要： Embodiments of the disclosure concern methods and compositions for immunotherapy for human papillomavirus infection and diseases associated therewith. In specific embodiments, methods concern production of immune cells that target one or more antigens of HPV16 and/or HPV18, including methods with stimulation steps that employ IL-7 and IL-15, but not IL-6 and/or IL-12. Other specific embodiments utilize stimulations in the presence of certain cells, such as costimulatory cells and certain antigen presenting cells.

    摘要翻译： 本公开的实施方案涉及用于人乳头瘤病毒感染和与之相关的疾病的免疫疗法的方法和组合物。 在具体的实施方案中，方法涉及产生靶向HPV16和/或HPV18的一种或多种抗原的免疫细胞，包括使用IL-7和IL-15但不使用IL-6和/或IL-12的刺激步骤的方法。 其他具体的实施方案在某些细胞如共刺激细胞和某些抗原呈递细胞的存在下利用刺激。

    CONSTITUTIVELY ACTIVE CYTOKINE RECEPTORS FOR CELL THERAPY
    9.
    发明申请
    CONSTITUTIVELY ACTIVE CYTOKINE RECEPTORS FOR CELL THERAPY 审中-公开
    组成型细胞因子受体在细胞治疗中的应用

    公开(公告)号：WO2018038945A1

    公开(公告)日：2018-03-01

    申请号：PCT/US2017/046588

    申请日：2017-08-11

    申请人： BAYLOR COLLEGE OF MEDICINE

    发明人： SHUM, Thomas C.T. ,  GOTTSCHALK, Stephen M.G. ,  OMER, Bilal ,  ROONEY, Cliona M.

    IPC分类号： C07K14/00 ,  A61K38/19

    摘要： Embodiments of the disclosure include methods and compositions for enhancing expansion of immune cells for immunotherapy. In particular embodiments, immune cells, such as T-cells, express a constitutively active cytokine receptor in which the transmembrane and endodomains are able to provide an activating signal separately from any input to the corresponding exodomain to which they are operably linked. In specific embodiments, the transmembrane and endodomain from IL-7Rα is utilized with the exodomain of CD34.

    摘要翻译： 本公开的实施方案包括用于增强用于免疫疗法的免疫细胞扩增的方法和组合物。 在具体的实施方案中，免疫细胞例如T细胞表达组成型活性细胞因子受体，其中跨膜和内结构域能够提供与其可操作连接的相应外结构域的任何输入分开的激活信号。 在具体的实施方案中，来自IL-7Rα的跨膜和内结构域与CD34的外结构域一起使用。

    PROCESS OF EXPANDING T CELLS
    10.
    发明申请
    PROCESS OF EXPANDING T CELLS 审中-公开
    扩增T细胞的过程

    公开(公告)号：WO2013088114A1

    公开(公告)日：2013-06-20

    申请号：PCT/GB2012/050896

    申请日：2012-04-23

    申请人： CELL MEDICA LIMITED ,  ROONEY, Cliona M. ,  LEEN, Ann M. ,  VERA, Juan F. ,  NGO, Minhtran V. ,  KNAUS, Rainer Ludwig ,  BAYLOR COLLEGE OF MEDICINE

    发明人： ROONEY, Cliona M. ,  LEEN, Ann M. ,  VERA, Juan F. ,  NGO, Minhtran V. ,  KNAUS, Rainer Ludwig

    IPC分类号： C12N5/0783 ,  A61K35/14

    CPC分类号： C12N5/0638 ,  A61K35/15 ,  A61K35/17 ,  A61K39/00 ,  A61K2035/124 ,  C12N2501/2304 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2502/1121

    摘要： The present disclosure relates to a novel process for in vitro expansion of autologous or allogenic antigen specific T cellscomprising the steps:a)culturing a population of autologous PCMB cells in the presence of: i) dendritic cells which have been pulsed with a peptide/peptide mix relevant to a target antigen OR a peptide/peptide mix relevant to a target antigen, and ii) at least one cytokine, and b)culturing a population of T cells from step a)in the presence of: i) dendritic cells which have been pulsed with a peptide/peptide mix relevant to a target antigen OR autologous antigen presenting T cells (T-APC's) cells which have been pulsed with a peptide/peptide mix relevant to a target antigen and an artificial co-stimulatory factor, and ii) optionally a cytokine, and characterized in that the process does not employ live virus and/or viral vectors or the use of DNA or RNA encoding antigens or recombinant target antigens in the expansion of the relevant T cell population. The disclosure also extends to cell populations obtained from said process, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent patients.

    摘要翻译： 本公开涉及用于体外扩增自体或同种异体抗原特异性T细胞的新方法，其包括以下步骤：a）在存在下培养一群自体PCMB细胞：i）已经用肽/肽脉冲的树突状细胞 与目标抗原相关的混合物或与靶抗原相关的肽/肽混合物，和ii）至少一种细胞因子，和b）在下述存在的情况下培养来自步骤a）的T细胞群：i）树突状细胞，其具有 用与靶抗原呈递T细胞（T-APC's）的肽/肽混合物相关的肽/肽混合物，其已用与靶抗原和人工共刺激因子相关的肽/肽混合物脉冲，以及ii ）任选的细胞因子，其特征在于该方法不使用活病毒和/或病毒载体，或在相关T细胞群扩增中使用编码抗原或重组靶抗原的DNA或RNA。 本公开还延伸到从所述方法获得的细胞群，包含所述细胞群的药物组合物和用于治疗的细胞和组合物的用途，特别是病毒感染和/或癌症的治疗或预防，例如免疫受损或免疫能力 耐心。