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公开(公告)号：WO2021026259A1
公开(公告)日：2021-02-11
申请号：PCT/US2020/045048
申请日：2020-08-05
IPC分类号： G01N35/10 , G01N33/536
摘要： A method (10) for automatically diluting a patient sample (20) onboard an immunoassay diagnostic system (100) includes: a) pipetting a first amount (22) of the patient sample (20) from a primary sample vessel (30) at a sample presentation unit (142) to a sample vessel (32) with a sample pipetting device (152); b) pipetting a second amount (26) of the patient sample (20) from the sample vessel (32) to a first dilution vessel (36) with the sample pipetting device (152); c) pipetting a first amount (62) of diluent (60) to the first dilution vessel (36) with a reagent pipetting device (162) thereby making a first patient sample dilution (50); and d) storing the first dilution vessel at a sample storage unit (158).
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公开(公告)号：WO2018081617A2
公开(公告)日：2018-05-03
申请号：PCT/US2017/058838
申请日：2017-10-27
发明人： MIZUTANI, Takayuki , NAZEMI, Leila , DEWITT, Arthur, Conan , YANCEY, Stephanie , WILLETTE, Marie , BUSACKER, Rebecca , BARNABEI, Matt , SEO, Katsuhiro , FUJII, Shigeru , UMEBARA, Kazuki
摘要： Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.
摘要翻译： 提供了自动物质制备和评估系统和方法，用于制备和评估流体物质，例如流体。 带有体液的样品，容器中和/或分配头中。 该系统和方法可以检测容积，评估完整性并检查容器和/或分配头中的颗粒浓度。
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公开(公告)号：WO2023086300A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/049153
申请日：2022-11-07
发明人： MIZUTANI, Takayuki , SAWHNEY, Amit , NOWAK, Kevin Louis , HOLMES, Laura Elizabeth Schilling , TUBMAN, Jessica Melissa Mattke
IPC分类号： G01N21/65
摘要： The described technology provides systems (100) and methods for determining concentration of an analyte (308) of interest using Surface Enhanced Raman Spectroscopy (SERS). An automated SERS system (100) can include a body (102) for accepting a substrate (200, 210, 220, 230, 240, 300), a fluid handling system (104), a light source (108), and a detector (106) that collects and detects Raman scattered light.
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公开(公告)号：WO2019060373A1
公开(公告)日：2019-03-28
申请号：PCT/US2018/051679
申请日：2018-09-19
CPC分类号： G01N21/76 , G01J1/44 , G01N21/27 , G01N33/5302 , G01N2021/135 , G01N2201/022 , G01N2201/1241 , G01N2201/127 , G01N2201/12753
摘要： A luminometer (400) includes a light detector (630) configured to sense photons (135). The luminometer (400) includes an analog circuit (915a) configured to provide an analog signal (965) based on the photons (135) emitted from assay reactions over a time period and a counter circuit (915b) configured to provide a photon count (970) based on the photons (135) emitted from the assay reactions over the time period. The luminometer (400) includes a luminometer controller (905) configured to, in response to an analog signal value of the analog signal (965) being greater than a predetermined value, determine and report a measurement value of the photons (135) emitted from the assay reactions over the time period based on the analog signal value of the analog signal (965) and a linear function (1010). Optionally, the linear function (1010) is derived from a relationship between the analog signal (965) and the photon count (970).
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5.发明申请
公开(公告)号：WO2023073667A1
公开(公告)日：2023-05-04
申请号：PCT/IB2022/060485
申请日：2022-10-31
摘要： A system (100) is provided for an automated analyzer (10) having an analyzer arrangement (20) configured to consume liquid consumables (30L) when in an active mode (12). The liquid consumables (30L) are delivered to the automated analyzer (10) via consumables containers (30). The system (100) comprises a storage magazine (120) configured to removably hold at least one of the consumables containers (30), a tray (150) configured to manually receive one or more of the consumables containers (30) from an operator at least while the analyzer arrangement (20) is in the active mode (12), and a transfer system (250) configured to transfer one or more of the consumables containers (30) at least between the tray (150) and the storage magazine (120). The transfer system (250) transfers one or more of the consumables containers (30) to or from the storage magazine (120) at least while the tray (150) manually receives one or more of the consumables containers (30) from the operator.
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公开(公告)号：WO2019126363A1
公开(公告)日：2019-06-27
申请号：PCT/US2018/066561
申请日：2018-12-19
IPC分类号： G01N33/487 , G01N33/94 , G01N33/82 , G01N27/62 , G01N33/68
摘要： One embodiment of the invention is directed to a sample processing system for analyzing a biological sample from a patient. The sample processing system comprises: a plurality of analyzers comprising at least one mass spectrometer, wherein each analyzer in the plurality of analyzers is configured to acquire at least one measurement value corresponding to at least one characteristic of the biological sample; at least one data storage component which stores (i) a list of parameters for the plurality of analyzers, and (ii) at least two condition sets, which contain data associated with completing one or more test orders. The condition sets contain data which differ by at least one variable; and a control system operatively coupled to the plurality of analyzers, and the at least one data storage component. The control system is configured to (i) determine which condition set of the at least two condition sets to use based on the determined condition set, (ii) determine which analyzer or analyzers of the plurality of analyzers to use to process each test order based on the determined condition set and one or more parameters from the list of parameters, and (iii) cause the determined analyzer or analyzers to acquire one or more measurement values for the biological sample.
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公开(公告)号：WO2018217778A1
公开(公告)日：2018-11-29
申请号：PCT/US2018/033927
申请日：2018-05-22
摘要： An integrated sample processing system including an analyzer and a mass spectrometer is disclosed. The integrated sample processing system can perform multiple different types of detection, thereby providing improved flexibility and better accuracy in processing samples. The detection systems in the sample processing system may include an optical detection system and a mass spectrometer.
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公开(公告)号：WO2022146842A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/064952
申请日：2021-12-22
申请人： BECKMAN COULTER, INC. , MATSUSHITA, Atsushi , NOWAK, Kevin L. , MIZUTANI, Takayuki , O'REILLY, Aaron P.
摘要： A system comprises: a sample analyzing device reading measurements associated with a liquid sample; a display device displaying a graphical user interface (GUI) to a current user of the automated sample analyzer; processing circuitry; and a memory storing: a receiving engine which receives the measurements associated with the liquid sample from the sample analyzing device and storing the received measurements in memory; a configuration control engine which sets a configuration of a user model to correspond to the current user of the automated sample analyzer; a learning engine which detects and collect at least one pattern of interaction of the current user with the GUI; and a user interface engine which configures the GUI according to user-dependent configuration data of the configuration of the user model corresponding to the current user.
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公开(公告)号：WO2022146591A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/060930
申请日：2021-11-29
摘要： The presently claimed and described technology provides improved calibration and validation procedures for sample containers (e.g., cuvettes) in automated chemical analyzers. The claimed and described technology further provides methods of operating an automated analyzer that allows for the automation of calibrating and tracking the integrity of individual sample containers (e.g., cuvettes) in parallel with measuring constituent samples. These methods eliminate the need to alternate between a diagnostic mode and measurement mode when performing system maintenance, such as validating cuvette integrity, calibrating absorbance baseline, and replacing cuvettes. As such, the presently claimed and described technology can reduce downtime and improve the clinical lab productivity significantly by allowing for this system maintenance to occur simultaneously with sample analysis.
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公开(公告)号：WO2022146582A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/060528
申请日：2021-11-23
摘要： An external calibration curve relies on external calibrators containing known concentrations of a target analyte that can deteriorate over time, leading to inaccurate results. Generating new calibration curves often requires preparing several calibrators to obtain calibration points needed for generating the calibration curves. Preparing the calibrators necessary for multi-point calibration curves requires operator preparation time and can introduce handling errors. The presently claimed and described technology provides a clinical laboratory automation system, including a fluid handling system, an analyzer component, and a mass spectrometer. The clinical laboratory automation system can provide automated calibration using one calibrator to prepare one or more calibrator dilutions used to generate a calibration curve for the quantitative measurement of a target analyte in a sample. The clinical laboratory automation analyzer may also provide an automated evaluation of pipettor dispensing volume and adjustment of the pipettor actuator to deliver an accurate dispensing volume.
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