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6 条记录 (耗时 0.017 秒)

    CELL DISRUPTION
    1.
    发明申请
    CELL DISRUPTION 审中-公开
    细胞破坏

    公开(公告)号：WO2011157989A3

    公开(公告)日：2012-02-16

    申请号：PCT/GB2011000898

    申请日：2011-06-15

    申请人： BG RES LTD ,  NAZARETH NELSON ,  EDGE DAVID ,  WARD DAVID

    发明人： NAZARETH NELSON ,  EDGE DAVID ,  WARD DAVID

    IPC分类号： C12N1/06 ,  B01L7/00 ,  C12M1/02 ,  C12M1/33 ,  F25B21/02

    CPC分类号： C12N15/1003 ,  B01L3/5029 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2200/141 ,  B01L2200/147 ,  B01L2300/044 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/049 ,  C12N1/066 ,  C12N1/08 ,  F25B21/04

    摘要： A process for the disruption of a biological cell comprising freezing, boiling or perhaps alternately freezing and boiling the material containing the biological cell using a thermoelectric cell a base face whereof is contiguous with a heat sink/source held at a substantially constant temperature and a working face. Apparatus for carrying out the disruption process comprises a peltier cell a base face of which is flexibly attached to a heat sink arranged to be kept at a constant temperature of around 50°C and a working face of which is contiguous with a reaction vessel or a reaction vessel holder. Reversal of the voltage in the peltier cell enables the working face alternately to reach below freezing and above boiling temperatures, and/or with use of a resistive wire on the vessel holder for heating with the TEC used purely for cooling The peltier cell base face is constructed of materials which tend to inhibit disintegration of the peltier cell brought about by expansion and contraction under heat.

    摘要翻译： 一种用于破坏生物细胞的方法，包括使用热电池冷冻，沸腾或者可能交替地冷冻和沸腾含有生物细胞的材料，其基面与保持在基本上恒定的温度的热沉/源连接，并且工作 面对。 用于进行破碎处理的装置包括一个珀耳帖细胞，其基面灵活地连接到散热器，该散热器被设置成保持在约50℃的恒定温度，其工作面与反应容器或 反应容器 在皮肤细胞中的电压反转使得工作面交替地达到低于冰点和沸点以上的温度，和/或使用电阻丝在容器保持器上用于纯化用于冷却的TEC加热珀耳帖细胞基面是 由倾向于抑制由加热引起的膨胀和收缩引起的珀耳帖细胞崩解的材料构成。

    IMPROVEMENTS IN REACTION APPARATUS
    3.
    发明申请
    IMPROVEMENTS IN REACTION APPARATUS 审中-公开
    反应装置的改进

    公开(公告)号：WO2008035074A3

    公开(公告)日：2008-09-18

    申请号：PCT/GB2007003564

    申请日：2007-09-18

    申请人： BG RES LTD ,  WARD DAVID ,  EDGE DAVID ,  NAZARETH NELSON

    发明人： WARD DAVID ,  EDGE DAVID ,  NAZARETH NELSON

    IPC分类号： B01L7/00

    CPC分类号： B01L3/50851 ,  B01L7/52 ,  B01L2200/147 ,  B01L2300/0654 ,  B01L2300/1822 ,  B01L2300/1827

    摘要： Apparatus for biological or chemical reactions, in particular PCR, and comprising a heat removal module adapted to receive snugly a reaction vessel in such a manner as to create good thermal conductivity contact between the module and the vessel, the module being formed of a thermally conductive material having therein a channel adapted for the flow of a coolant liquid. Preferably it is constructed to receive an array of 96n microtitre wells formed of electrically conductive plastics (ecp) lined with an electrically insulative material.

    摘要翻译： 用于生物或化学反应的装置，特别是PCR，并且包括热量去除模块，该热量去除模块适合于紧密地接收反应容器，以便在模块和容器之间产生良好的导热性接触，该模块由导热 其中具有适于冷却液流动的通道的材料。 优选地，其被构造成接收由​​衬有电绝缘材料的导电塑料（ecp）形成的96n微量滴定孔的阵列。

    THERMAL CYCLING APPARATUS AND PROCESS
    5.
    发明申请
    THERMAL CYCLING APPARATUS AND PROCESS 审中-公开
    热循环装置和工艺

    公开(公告)号：WO2008107683A2

    公开(公告)日：2008-09-12

    申请号：PCT/GB2008000775

    申请日：2008-03-06

    申请人： BG RES LTD ,  WARD DAVID ,  NAZARETH NELSON

    发明人： WARD DAVID ,  NAZARETH NELSON

    IPC分类号： B01L7/00

    CPC分类号： F25B21/04 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/1822 ,  B01L2300/185

    摘要： A thermal cycling apparatus and process wherein at least one reaction vessel is associated with a thermo-electric cooler (TEC) device, such as a peltier cell, arranged to provide both heating and cooling of the reaction vessel. One side of the TEC is associated with the said at least one reaction vessel and the other side is arranged in use to be maintained at a temperature intermediate the highest temperature and the lowest temperature used in the thermal cycling operation. Electric current is supplied to the TEC in one direction whereby the said one side becomes hotter than the said other side and then in the other direction whereby the said one side becomes cooler than the said other side.

    摘要翻译： 一种热循环装置和方法，其中至少一个反应容器与热电冷却器（TEC）装置（例如珀耳帖细胞）相关联，该装置被设置成提供反应容器的加热和冷却。 TEC的一侧与所述至少一个反应容器相关联，另一侧被安排在使用中以保持在热循环操作中使用的最高温度和最低温度之间的温度。 在一个方向上向TEC提供电流，由此所述一侧变得比所述另一侧更热，然后在另一方向上，由此所述一侧变得比所述另一侧更冷。

    NUCLEIC ACID AMPLIFICATION
    6.
    发明申请
    NUCLEIC ACID AMPLIFICATION 审中-公开
    核酸扩增

    公开(公告)号：WO2017055791A3

    公开(公告)日：2017-05-26

    申请号：PCT/GB2016000178

    申请日：2016-09-30

    申请人： BG RES LTD

    发明人： NAZARETH NELSON ,  EDGE DAVID ,  TYLER ADAM

    IPC分类号： B01L3/00 ,  B01L7/00 ,  C12M1/02 ,  C12Q1/68 ,  G01N21/00

    CPC分类号： B01L7/52 ,  B01L3/508 ,  B01L2200/04 ,  B01L2200/12 ,  B01L2300/042 ,  B01L2300/0851 ,  B01L2300/0883 ,  B01L2300/12 ,  C12Q1/68 ,  C12Q1/686 ,  G01N21/0303 ,  G01N2021/6439

    摘要： A nucleic acid amplification (NAA) reaction vessel comprising: two opposing major walls; a minor wall system attaching the major walls and thus defining a reaction chamber having a base, the major and minor walls being formed of a thermally conductive material; an inlet port permitting the introduction of fluid into the reaction vessel; a cap arranged for sealing the inlet port; and a light transmissive window at the base of the vessel reaction chamber; the vessel having a capacity greater than 100 microlitres. Process and apparatus employing the vessel are also described.

    摘要翻译： 核酸扩增（NAA）反应容器包括：两个相对的主壁; 小壁系统，其连接主壁并因此限定具有基部的反应室，主壁和次壁由导热材料形成; 允许将流体引入反应容器的入口端口; 设置用于密封入口的帽; 和位于容器反应室底部的透光窗口; 容器的容量大于100微升。 还描述了采用该容器的过程和设备。