公开(公告)号：WO2018018151A1

公开(公告)日：2018-02-01

申请号：PCT/CA2017/050903

申请日：2017-07-28

Applicant: BIOAMBER INC.

Inventor： LAU, Man Kit ,  HASS, Cathy Staloch ,  MILLIS, James R.

IPC: C12N1/21 ,  C07C59/245 ,  C07C59/325 ,  C07C59/40 ,  C12N1/15 ,  C12N1/19 ,  C12N15/52 ,  C12N15/53 ,  C12N15/54 ,  C12N15/55 ,  C12P19/32 ,  C12P7/46 ,  C12P7/62

Abstract: The description relates to, inter alia , recombinant microorganisms, engineered metabolic pathways, chemical catalysts, and products produced through the use of the described methods and materials. The products produced include methylenemalonic acid and intermediates, as well as their salts and esters.

Abstract translation: 描述涉及，尤其是重组微生物，工程化代谢途径，化学催化剂和通过使用所述方法和材料生产的产品。 生产的产品包括亚甲基丙二酸和中间体以及它们的盐和酯。

公开(公告)号：WO2015191763A2

公开(公告)日：2015-12-17

申请号：PCT/US2015/035178

申请日：2015-06-10

Applicant: BIOAMBER INC.

Inventor： BAKER, Ralph Thomas ,  WHITE, James F. ,  MANZER, Leo E. ,  NTAIS, Spyridon ,  BARANOVA, Olena ,  THAPA, Indira ,  LAU, Man Kit ,  HASS, Cathy Staloch

IPC: C07C51/09

CPC classification number: C07C51/38 ,  B01J21/18 ,  B01J23/44 ,  B01J27/053 ,  B01J27/232 ,  C07C51/31 ,  C12R1/645 ,  C07C55/14

Abstract: This disclosure relates to methods for converting homocitric acid to adipic acid, and more particularly to methods of using metal catalysts to catalyze the conversion of homocitric acid to adipic acid.

Abstract translation: 本公开内容涉及将高酸反应转化为己二酸的方法，更具体地涉及使用金属催化剂催化高柠檬酸转化为己二酸的方法。

公开(公告)号：WO2014031724A1

公开(公告)日：2014-02-27

申请号：PCT/US2013/055950

申请日：2013-08-21

Applicant: BIOAMBER INC.

Inventor： LAU, Man Kit

IPC: C12N9/04 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N9/00 ,  C12P13/04

CPC classification number: C12P13/001 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0016 ,  C12N9/1096 ,  C12N9/13 ,  C12N9/16 ,  C12N9/88 ,  C12N9/93 ,  C12P13/005 ,  C12P13/04

Abstract: A chemical having the formula (S) 2-amino-6-hydroxypimelate. (S)-2-amino-6- hydroxypimelate can be made using a method comprising culturing a cell comprising an exogenous nucleic acid sequence encoding an enzyme that catalyzes the substrate to product conversion of (S)-2-amino-6-oxopimelate to (S)-2-amino-6-hydroxypimelate and separating the (S)-2-amino-6-hydroxypimelate. The cell may be a recombinant microorganism for producing aminocaproic acid or hexamethylenediamine from (S)-2- amino-6-hydroxypimelate comprising at least one exogenous nucleic acid sequence that expresses at least one polypeptide with substrate preference for homolysine, and amino acid decarboxylase with substrate preference for alpha-aminopimelate.

Abstract translation: 具有式（S）2-氨基-6-羟基庚酸酯的化学式。 （S）-2-氨基-6-羟基庚酸酯可以使用包括培养包含编码催化底物的酶的外源核酸序列的细胞的方法制备（S）-2-氨基-6-氧代庚酸成分转化为 （S）-2-氨基-6-羟基庚酸酯并分离（S）-2-氨基-6-羟基庚酸酯。 细胞可以是用于从（S）-2-氨基-6-羟基庚二酸生产氨基己酸或六亚甲基二胺的重组微生物，其包含至少一种外源核酸序列，其表达至少一种具有底物优选homolysine的多肽，以及氨基酸脱羧酶与 底物优选α-氨基庚二酸酯。