公开(公告)号：WO2018022971A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/044333

申请日：2017-07-28

Applicant: BIOFIRE DIAGNOSTICS, LLC. ,  BIOFIRE DEFENSE, LLC.

Inventor： JONES, David E. ,  BRIMHALL, Owen D. ,  POLITIS, Jonathan J. ,  TAYLOR, Logan M. ,  MAUGHN, Marshall A. ,  COOLEY, Dirk D. ,  RIRIE, Kirk M. ,  WERNEREHL, Aaron D. ,  ZIMMERMAN, Taylor S. ,  CHAMBERLAIN, Anson Cole ,  PASKO, Christopher P. ,  RILEY, Patrick L. ,  FOWDEN, Sarah M. ,  NIELSEN, David R. ,  DERRICK, Michael B. ,  ANTONINI, Gregory J. ,  MILLER, Christopher Ryan ,  ARNOTT, Kristin Alan ,  BROWN, Dale Gordon ,  JOHNSON, Kyle K. ,  FRANDSEN, Matthew K. ,  JACKSON, G. Paul

IPC: C12Q1/68 ,  C12P19/34 ,  B01L7/52

Abstract: Instruments and methods for amplifying nucleic acids in a sample provided in a flexible, self-contained, substantially closed sample container.

Abstract translation: 用于扩增样品中的核酸的仪器和方法提供在柔性的，自包含的，基本封闭的样品容器中。

公开(公告)号：WO2017106542A1

公开(公告)日：2017-06-22

申请号：PCT/US2016/066998

申请日：2016-12-15

Applicant: BIOFIRE DEFENSE, LLC

Inventor： RILEY, Patrick L. ,  ABBOTT, Richard David ,  NAY, Lyle M. ,  FOWDEN, Sarah M.

IPC: G01N21/27 ,  B01F13/00 ,  B01J13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B41M3/14

CPC classification number: G01N21/6456 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/148 ,  B41M3/144 ,  G01N21/278 ,  G01N21/64 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2021/6439

Abstract: A solid fluorescence standard that can be used to calibrate and/or normalize a device (e.g., a scientific instrument) that is configured for generating and collecting fluorescence data. A fluorescence standard disclosed herein includes an adhesive (e.g., a low viscosity, substantially optically transparent, solvent-free, radiation curable adhesive, such as, but not limited to, a UV curable adhesive), and a selected quantity of fluorescent particles (e.g., quantum dots) dispersed in the adhesive. The adhesive and the fluorescent particles are mixed together and disposed in a sample well. The adhesive is then cured and solidified, which yields a solid fluorescence standard in the well.

Abstract translation: 可用于校准和/或标准化设备（例如，科学仪器）的固体荧光标准，所述设备被配置用于生成和收集荧光数据。 本文公开的荧光标准包括粘合剂（例如，低粘度，基本光学透明，无溶剂，可辐射固化的粘合剂，例如但不限于UV可固化粘合剂）和选定量的荧光颗粒（例如 ，量子点）分散在粘合剂中。 将粘合剂和荧光颗粒混合在一起并置于样品孔中。 然后将粘合剂固化并固化，从而在孔中产生固体荧光标准。