公开(公告)号：WO2019083212A1

公开(公告)日：2019-05-02

申请号：PCT/KR2018/012146

申请日：2018-10-16

Applicant: 주식회사 셀레믹스

Inventor： 정유신 ,  이상협 ,  류태훈

IPC: B01L3/00 ,  B01L9/00 ,  C12M1/34

CPC classification number: B01L3/5085 ,  B01L9/523 ,  B01L2200/0652 ,  B01L2300/06 ,  B01L2300/0654 ,  B01L2300/10 ,  C12M41/00

Abstract: 수분 보유 매질이 배치된 기판; 상기 수분 보유 매질 내에 함유된 생물학적 물질; 상기 생물학적 물질을 관찰하기 위한 관찰 도구; 상기 생물학적 물질을 상기 기판으로부터 분리하기 위한 추출 도구; 상기 수분 보유 매질로부터 증발하는 수분을 보충하기 위한 수분 공급부; 및 상기 기판과 상기 수분 공급부 사이에 존재하는 영역의 온도 혹은 습도를 측정하는 습도 제어부를 포함하는 생물학적 물질 분리장치가 제공된다.

公开(公告)号：WO2019010229A1

公开(公告)日：2019-01-10

申请号：PCT/US2018/040799

申请日：2018-07-03

Applicant: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Inventor： SAMUEL, Raheel ,  LAMBERT, Christopher, J. ,  GALE, Bruce, K. ,  BONKOWSKY, Joshua, L. ,  FRESHNER, Briana ,  CHUNG, Arlen

IPC: C12M3/06 ,  B01L3/00 ,  C12M1/00

CPC classification number: B01L3/5085 ,  B01L2200/0647 ,  B01L2300/16 ,  C12Q1/6806 ,  C12Q2531/107 ,  C12Q2563/159

Abstract: A device for rapid non-destructive genetic material collection can include a multi-reservoir array (202) and a movement mechanism. The multi-reservoir array (202) can include multiple reservoirs (204). A plurality of the multiple reservoirs (204) can include an abrasive surface (210) capable of retaining a source of genetic material in a liquid carrier. The abrasive surface (210) has a roughness. The movement mechanism can be operable to move the multi-reservoir array (202) in an oscillating motion sufficient to create relative movement between the abrasive surface (210) and the source of the genetic material in order to remove a portion of genetic material from the source of the genetic material without destroying the source of the genetic material or the portion of the genetic material that is removed.

公开(公告)号：WO2018154306A1

公开(公告)日：2018-08-30

申请号：PCT/GB2018/050464

申请日：2018-02-22

Applicant: MEDHERANT, LTD

Inventor： NURUMBETOV, Gabit ,  HADDLETON, David ,  TOMBS, Emma ,  NIKOLAOU, Vasiliki ,  DAVIS, Nigel

IPC: B01L3/00

CPC classification number: B01L3/5025 ,  B01F11/0082 ,  B01F13/0827 ,  B01L3/5085 ,  B01L2300/042 ,  B01L2300/0609 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2400/0472 ,  G01N13/00 ,  G01N2013/003

Abstract: A diffusion test system is disclosed. The system comprises a base plate (13; Fig. 5) having a plurality of wells (14), each well having a blind end (51). The system comprises at least one elongate hollow plug (42), each plug comprising a wall (63; Fig. 13) running between first and second open ends (61, 62; Fig. 13) and defining a cavity (64; Fig. 13) therein. Each plug is configured to be removably securely-insertable into a respective well. The system may also comprise at least one magnetic agitator (43), each magnetic agitator configured to be receivable in a respective cavity.

公开(公告)号：WO2018121818A1

公开(公告)日：2018-07-05

申请号：PCT/DK2017/050348

申请日：2017-10-20

Applicant: ESCO MEDICAL APS

Inventor： PEDERSEN, Thomas William

IPC: C12M1/12 ,  C12M1/32 ,  C12M1/00 ,  A01N1/02 ,  B01L3/00

CPC classification number: C12M23/12 ,  A01N1/0268 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/0809 ,  B01L2300/0832 ,  C12M23/06 ,  C12M47/20

Abstract: The invention related to a device (100) for culturing a biological material, said device comprising a first element (2) and a second element (4); wherein said first element (2) is having an extension in a lengthwise direction (X), an extension in a transverse direction (Y) and an extension in a direction (Z) perpendicular to the lengthwise direction as well as to the transverse direction; wherein said second element (4) is having an extension in a lengthwise direction (X), an extension in a transverse direction (Y) and an extension in a direction (Z) perpendicular to the lengthwise direction as well as to the transverse direction; wherein said first element (2) comprises one or more rods (6, 6', 6", 6"', 8, 8', 8", 8"'); wherein said second element (4) comprises a cylindrical compartment (26) comprising a first open end (30) confined by a rim (32); wherein the outer dimensions of said first element (2) and the inner dimensions of said compartment (26) in said second element (4) are adapted to each other in such a way that the first element can be slit in and out of the compartment in the second element, in a lengthwise direction (X), thereby changing the accessibility to one or more of the plurality of culture wells 24 between an exposed configuration in which the culture wells are accessible and not covered by the second element (4), and a closed configuration in which the culture wells are covered by the second element (4).

公开(公告)号：WO2018006050A1

公开(公告)日：2018-01-04

申请号：PCT/US2017/040444

申请日：2017-06-30

Applicant: BECKMAN COULTER, INC.

Inventor： TADASHI, Haga ,  TAKEUCHI, Tomohiko

IPC: G01N35/10

CPC classification number: G06T7/0008 ,  B01L3/5085 ,  B01L2200/0605 ,  B01L2200/143 ,  B01L2200/148 ,  G01N35/1011 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/30164 ,  G06T2207/30232

Abstract: An automated analysis instalment operates to detect inadequate dispensation of a fluidic substance on a tray. The instrument includes an image capturing device to capture an image of at least a portion of the tray including a receptacle portion and a surrounding portion around the receptacle portion. The instrument then identifies the surrounding portion of the at least the portion of the tray in the image, evaluates color components of the image corresponding to the surrounding portion of the at least the portion of the tray, and determines whether the fluidic substance is present on the surrounding portion of the at least the portion of the tray based on at least one of the color components.

Abstract translation: 自动分析装置用于检测托盘上流体物质的分配不充分。 该仪器包括图像捕获装置以捕获托盘的至少一部分的图像，该图像包括容器部分和围绕容器部分的周围部分。 然后仪器识别图像中托盘的至少部分的周围部分，评估与托盘的至少部分的周围部分对应的图像的颜色分量，并确定流体物质是否存在于 基于至少一种颜色成分，托盘的至少一部分的周围部分。

公开(公告)号：WO2017142410A1

公开(公告)日：2017-08-24

申请号：PCT/NL2017/050098

申请日：2017-02-17

Applicant: PERKINELMER HEALTH SCIENCES B.V.

Inventor： VAN BEURDEN, Rob

IPC: C12M1/32 ,  B01L3/00 ,  C12M1/00 ,  C12M1/12

CPC classification number: C12M23/12 ,  B01L3/5085 ,  B01L9/523 ,  B01L2200/025 ,  B01L2200/0647 ,  B01L2200/12 ,  B01L2300/04 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0832 ,  B01L2300/161 ,  C12M23/22 ,  C12M25/14

Abstract: The invention relates to means and methods for cell culturing and cell analysis, in particular to devices designed for growth, maintenance and/or microscopic analysis of 3D cell culture models, like cell aggregates or spheroids. Provided is an insert plate for detachably attaching to a standardized microplate and having a plurality of wells, the insert plate having a main body comprising a plurality of tubes for receiving a sample, each tube having a liquid impermeable optically clear bottom portion to allow for microscopic imaging and wherein at least part of said bottom portion has a concave arcuate surface, the plurality of tubes being positioned to fit into and align with a corresponding well of the microplate when the microplate and the insert plate are attached. Also provided is an assembly of the insert plate and a microplate.

Abstract translation: 本发明涉及用于细胞培养和细胞分析的手段和方法，具体涉及设计用于3D细胞培养模型（例如细胞聚集体或球体）的生长，维持和/或显微分析的装置。 提供了一种用于可拆卸地连接到标准化微孔板并具有多个孔的插入板，插入板具有包括多个用于接收样本的管的主体，每个管具有液体不可渗透的光学透明底部以允许显微镜 成像，并且其中所述底部的至少一部分具有凹形弓形表面，当所述微板和所述插入板连接时，所述多个管定位成配合到所述微板的相应孔中并与所述微板的相应孔对准。 还提供了插板和微板的组装。

公开(公告)号：WO2017106542A1

公开(公告)日：2017-06-22

申请号：PCT/US2016/066998

申请日：2016-12-15

Applicant: BIOFIRE DEFENSE, LLC

Inventor： RILEY, Patrick L. ,  ABBOTT, Richard David ,  NAY, Lyle M. ,  FOWDEN, Sarah M.

IPC: G01N21/27 ,  B01F13/00 ,  B01J13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L7/00 ,  B41M3/14

CPC classification number: G01N21/6456 ,  B01L3/5085 ,  B01L7/52 ,  B01L2200/148 ,  B41M3/144 ,  G01N21/278 ,  G01N21/64 ,  G01N21/6452 ,  G01N2021/6421 ,  G01N2021/6439

Abstract: A solid fluorescence standard that can be used to calibrate and/or normalize a device (e.g., a scientific instrument) that is configured for generating and collecting fluorescence data. A fluorescence standard disclosed herein includes an adhesive (e.g., a low viscosity, substantially optically transparent, solvent-free, radiation curable adhesive, such as, but not limited to, a UV curable adhesive), and a selected quantity of fluorescent particles (e.g., quantum dots) dispersed in the adhesive. The adhesive and the fluorescent particles are mixed together and disposed in a sample well. The adhesive is then cured and solidified, which yields a solid fluorescence standard in the well.

Abstract translation: 可用于校准和/或标准化设备（例如，科学仪器）的固体荧光标准，所述设备被配置用于生成和收集荧光数据。 本文公开的荧光标准包括粘合剂（例如，低粘度，基本光学透明，无溶剂，可辐射固化的粘合剂，例如但不限于UV可固化粘合剂）和选定量的荧光颗粒（例如 ，量子点）分散在粘合剂中。 将粘合剂和荧光颗粒混合在一起并置于样品孔中。 然后将粘合剂固化并固化，从而在孔中产生固体荧光标准。

公开(公告)号：WO2017097553A1

公开(公告)日：2017-06-15

申请号：PCT/EP2016/077797

申请日：2016-11-16

Applicant: BEHNK, Holger

Inventor： BEHNK, Holger

IPC: B01L3/00 ,  G01N33/49 ,  G01N21/03

CPC classification number: B01L3/508 ,  B01F13/0818 ,  B01F13/1022 ,  B01L3/5085 ,  B01L2200/0647 ,  B01L2300/0609 ,  B01L2300/0858 ,  G01N21/03 ,  G01N21/59 ,  G01N33/4905 ,  G01N2021/0378 ,  G01N2021/0382

Abstract: Die Erfindung betrifft eine Küvette zum Mischen einer Flüssigkeit. Die Küvette umfasst einen Innenraum (18) zur Aufnahme der Flüssigkeit und eine in dem Innenraum (18) ausgebildete Laufschiene (20) für eine Kugel (22), wobei die Laufschiene (20) von zwei Vorsprüngen (12, 13) gebildet wird, die von gegenüberliegenden Seitenwänden (10, 11) der Küvette (14) in den Innenraum (18) vorspringen. Erfindungsgemäß weist die Laufschiene einen geradlinigen Abschnitt auf und ist an beiden Enden nach oben umgelenkt. In der erfindungsgemäßen Küvette (14) lässt sich mit einer geringen Flüssigkeitsmenge ein hoher Füllstand erreichen, was für optische Messungen von Vorteil ist. Die Erfindung betrifft außerdem ein Messverfahren unter Verwendung der Küvette.

Abstract translation: 本发明涉及一种用于混合液体的厨房。 K个导航使用维特包括内部空间（18），用于接收所述F1导航使用液体和在所述内部（18）形成滑轨（20），用于导航用途为r的球（22），其中，所述工作轨2的（20）突起导航用途NTS（ （14）的相对的侧壁（10,11）突出到内部空间（18）中。 发明＆AUML;大街 导轨有一个直线段，两端向上偏转。 在本发明（14）的情况下，可以用少量液体实现高液位，这对于光学测量是有利的。 本发明还涉及一种使用厨房的测量方法。

公开(公告)号：WO2017040989A1

公开(公告)日：2017-03-09

申请号：PCT/US2016/050191

申请日：2016-09-02

Applicant: SAINT LOUIS UNIVERSITY

Inventor： ZUSTIAK, Silviya Petrova ,  AHMED, Naveed Zafar

IPC: G05B15/00

CPC classification number: B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/00644 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00743 ,  B01L3/5085 ,  C12M23/12 ,  C12M25/14 ,  C12N2531/00 ,  C12N2535/10 ,  C12N2539/00 ,  G03F7/027 ,  G03F7/038 ,  G03F7/2014

Abstract: The present invention provides a system for conservation and efficient use of energy through controlling and monitoring of devices. At least one processing controller connected to a sensor and a device, the processing controller configured to receive the ambient data from the sensor and operating parameters from the device; a user module configured to IO receive input parameters from a plurality of users; a central processing module, connected to the structure, the user module, and the admin module through wired and/or wireless connection, the central processing module configured to process the data received from the processing controller adapted in the zone of the structure and generate the optimum parameters for operating the device adapted in the zone to the structure.

Abstract translation: 本发明提供一种通过控制和监视装置来节约和有效利用能量的系统。 连接到传感器和设备的至少一个处理控制器，所述处理控制器被配置为从所述传感器接收环境数据并从所述设备接收操作参数; 用户模块，被配置为从多个用户接收输入参数; 中央处理模块，其通过有线和/或无线连接连接到所述结构，所述用户模块和所述管理模块，所述中央处理模块被配置为处理从所述结构区域适应的所述处理控制器接收到的数据，并且生成 将适于该区域的设备操作到结构的最佳参数。

公开(公告)号：WO2017033070A1

公开(公告)日：2017-03-02

申请号：PCT/IB2016/054248

申请日：2016-07-15

Applicant: GENCELL BIOSYSTEMS LTD.

Inventor： DALTON, Mark

IPC: B01L3/00 ,  G01N35/00

CPC classification number: C12N15/1075 ,  B01L3/5085 ,  B01L3/50851 ,  B01L2200/0673 ,  B01L2300/0829 ,  B01L2300/161 ,  C12Q1/6874 ,  G01N35/0099 ,  G01N35/1002

Abstract: Composite liquid cell supports are provided. Aspects of the supports include: a plurality of CLC containers, wherein each CLC container is configured to hold a CLC and comprises a fluorophilic inner surface having a water contact angle of 80 degrees or greater. The fluorophilic inner surface may have a first contact angle with a fluorous carrier liquid which is less than a second contact angle with an encapsulating liquid that is immiscible with the carrier liquid. The supports find use in, among other applications, CLC systems and devices. Also provided are methods of preparing and using CLC arrays that include the CLC supports of the invention.

Abstract translation: 提供复合液晶盒支架。 支撑件的方面包括：多个CLC容器，其中每个CLC容器被配置为保持CLC并且包括具有80度或更大的水接触角的富含荧光的内表面。 荧光内表面可以与氟载体液体具有与与载体液体不混溶的封装液体小于第二接触角的第一接触角。 支持在其他应用中可用于CLC系统和设备。 还提供了制备和使用包括本发明的CLC载体的CLC阵列的方法。