公开(公告)号：WO2019222816A1

公开(公告)日：2019-11-28

申请号：PCT/AU2019/051013

申请日：2019-09-20

Applicant: BIONOMICS LIMITED

Inventor： TOOP, Hamish ,  SINGH, Rajinder ,  SMITH, Erin ,  PAUL, Dharam ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe ,  CHERY, Florence ,  GARRIDO, Fabrice

IPC: C07D401/04 ,  A61P25/00 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/4166

Abstract: The present application relates generally to compounds useful for the treatment and/or enhancement of cognitive dysfunction and negative symptoms associated with CNS disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

公开(公告)号：WO2020000065A3

公开(公告)日：2020-01-02

申请号：PCT/AU2019/051194

申请日：2019-10-30

Applicant: BIONOMICS LIMITED

Inventor： TOOP, Hamish ,  PAUL, Dharam ,  SINGH, Rajinder ,  SMITH, Erin ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe ,  SCHAEFFER, Laurent ,  MICHAUT-SIMON, Celine ,  CHERY, Florence ,  GARRIDO, Fabrice

IPC: C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  A61K31/497 ,  A61K31/501 ,  A61P25/08 ,  A61P25/18 ,  A61P25/28

Abstract: The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.

公开(公告)号：WO2020000065A2

公开(公告)日：2020-01-02

申请号：PCT/AU2019/051194

申请日：2019-10-30

Applicant: BIONOMICS LIMITED

Inventor： TOOP, Hamish ,  PAUL, Dharam ,  SINGH, Rajinder ,  SMITH, Erin ,  BAZZINI, Patrick ,  CONTRERAS, Jean-Marie ,  MORICE, Christophe ,  SCHAEFFER, Laurent ,  MICHAUT-SIMON, Celine ,  CHERY, Florence ,  GARRIDO, Fabrice

IPC: C07D401/14

Abstract: The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.