公开(公告)号：WO9602235A1

公开(公告)日：1996-02-01

申请号：PCT/US9508861

申请日：1995-07-14

Applicant: BIOQUEST INC

Inventor： CHAGNON MARK S ,  BURKLE STEPHEN E ,  CARTER MICHELLE J ,  HAMILTON TRACY J ,  HAVELICK JOHN JR ,  KAPLAN DEBORAH A ,  MARZLOFF KRISTIN L

IPC: A61K9/127 ,  A61K47/48 ,  A61K49/18 ,  B03C1/01 ,  C12N11/14 ,  G01N33/543 ,  G01N33/551 ,  G01N33/554 ,  A61K9/16 ,  A61K9/50

CPC classification number: G01N33/554 ,  A61K9/1272 ,  A61K47/6923 ,  A61K49/1812 ,  A61K49/183 ,  A61K49/1854 ,  A61K49/186 ,  B03C1/01 ,  C12N11/14 ,  G01N33/54313 ,  G01N33/5434 ,  G01N33/551 ,  G01N2446/20 ,  G01N2446/80 ,  G01N2446/84 ,  G01N2446/90

Abstract: Novel N-RES agents for use in vitro and in vivo medical and biological applications, such as, for example MRI and/or intravenous administration of pharmaceutical agents are described. The novel N-RES agents are prepared by coating inorganic core particles with a poly(acrylic acid) - poly(alkylene ether) graft copolymer. The resulting polymer-coated inorganic particle cores are useful as imaging agents, therapeutic agents or carriers having increased circulation time due to decrease uptake or recognition by the RES.

Abstract translation: 描述了用于体外和体内医学和生物应用的新型N-RES试剂，例如药物的MRI和/或静脉内施用。 通过用聚（丙烯酸） - 聚（亚烷基醚）接枝共聚物涂覆无机芯颗粒来制备新的N-RES试剂。 得到的聚合物涂覆的无机颗粒芯可用作成像剂，治疗剂或载体，由于减少摄取或RES的识别而具有增加的循环时间。