公开(公告)号：WO2023074766A1

公开(公告)日：2023-05-04

申请号：PCT/JP2022/040029

申请日：2022-10-26

Applicant: 味の素株式会社

Inventor： 河戸　弥生 ,  中田　勇二 ,  伊地知　千織

IPC: C12N15/12 ,  C12Q1/02 ,  C12Q1/66 ,  G01N33/554 ,  G01N33/566 ,  A23L33/10 ,  C07K14/705

Abstract: アミノ酸臭を抑制するための技術を提供する。嗅覚受容体OR4S2および／またはOR4E2を利用してアミノ酸臭を抑制する物質をスクリーニングする。スクリーニングされた物質を利用して食品におけるアミノ酸臭を抑制する。

公开(公告)号：WO2022051669A1

公开(公告)日：2022-03-10

申请号：PCT/US2021/049148

申请日：2021-09-03

Applicant: ATLASXOMICS INC.

Inventor： GENNARO, Joseph C.

IPC: C12Q1/6841 ,  G01N33/554 ,  G01N33/567

Abstract: The present disclosure generally relates to methods for increasing the region of interest of spatial multi-omics techniques while retaining single-cell resolution. These methods can improve the scaling of region of interest dimension with input/output channels from linear to super-linear. In some embodiments, the method is performed by providing a plurality of probes of a first type to a first region of a sample, wherein at least a subset of the probes of the first type includes a first spatial barcode, providing a plurality of probes of a second type to a second region of the sample, wherein at least a subset of the probes of the second type includes a second spatial barcode, and providing a probe of a third type to a third region of the sample, wherein the probe of the third type comprises a third spatial barcode.

公开(公告)号：WO2021179892A1

公开(公告)日：2021-09-16

申请号：PCT/CN2021/077194

申请日：2021-02-22

Applicant: TAIPEI UNIVERSITY OF TECHNOLOGY

Inventor： HOU, Shao-Yi

IPC: G01N33/554

Abstract: A method and a system for detecting the presence of an analyte in a sample. The system, such as a diagnostic kit, for detecting the presence of an analyte in a sample, comprises (a) a recombinant bacterium or spore expressing one or more recombinant proteins on the surface thereof, wherein the recombinant protein specifically binds to the analyte directly or through a binding agent that specifically binds to the recombinant protein and the analyte, and (b) a signal-producing substance that can be detected.

公开(公告)号：WO2018144571A3

公开(公告)日：2018-08-09

申请号：PCT/US2018/016185

申请日：2018-01-31

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

Inventor： JOHNSTON, Stephen ,  WANG, Lu

IPC: C40B40/10 ,  C40B30/04 ,  G01N33/554 ,  C12Q1/02 ,  C12Q1/70

Abstract: Assays, arrays, and methods for distinguishing a bacterial infection from a viral infection are disclosed. The antibiotic crisis is in part driven by over prescription of antibiotics. There is a tendency, particular in pediatrics, to give an antibiotic even for viral infections. Thus, embodiments herein are directed to the problem of distinguishing a bacterial infection from a viral infection to reduce unnecessary antibiotic usage.

公开(公告)号：WO2018119173A1

公开(公告)日：2018-06-28

申请号：PCT/US2017/067787

申请日：2017-12-21

Applicant: FUNDAMENTAL SOLUTIONS CORPORATION

Inventor： ZUPANCIC, Thomas, J. ,  KITTLE, Joseph, D. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  BRODY, Richard, S. ,  WILLIAMS, Marvin, R.

IPC: C12Q1/6897 ,  G01N33/50 ,  G01N33/536 ,  G01N33/554 ,  G01N33/569 ,  G01N33/58

Abstract: A biosensor system for the detection of target analytes that includes a living biological cell of a predetermined type; a signal-generating reporter associated with the living biological cell; a signal transduction pathway or other activator mechanism or means associated with the signal-generating reporter; a universal detector element associated with the activator mechanism; and an analyte binding element associated with the universal detector element, wherein the analyte binding element is specific to both the universal detector element and a target analyte.

公开(公告)号：WO2017087429A1

公开(公告)日：2017-05-26

申请号：PCT/US2016/062115

申请日：2016-11-15

Applicant: SCIBAC INC.

Inventor： MUCHA, Jeanette M. ,  CANN, Anthony F.

IPC: G01N33/554

CPC classification number: C12N15/87 ,  C12N1/16 ,  C12N1/20 ,  C12N15/01 ,  C12N15/03 ,  C12N15/04 ,  C12N2502/70

Abstract: Described is a method to transfer chromosomal DNA between two microbial species without genetic engineering or vectors. The strains resulting from this method are chimeric microbial hybrids that can express a combination of genotypes from both parents.

Abstract translation: 描述了在没有基因工程或载体的情况下在两种微生物物种之间转移染色体DNA的方法。 这种方法产生的菌株是嵌合微生物杂种，可以表达来自父母双方的基因型组合。

公开(公告)号：WO2017027519A1

公开(公告)日：2017-02-16

申请号：PCT/US2016/046197

申请日：2016-08-09

Applicant: APOCELL, INC.

Inventor： DAVIS, Darren, W.

IPC: A61B5/00 ,  C12Q1/68 ,  G01N27/27 ,  G01N33/487 ,  G01N33/554

CPC classification number: G01N33/56966 ,  B03C5/005 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The present disclosure relates to an apparatus and methods for enriching and analyzing viable target particles of interest from a heterogeneous suspension containing target particles and non-target particles where the particles may be biological or non-biological. The method allows for the resulting target particles or a subset of target particles to undergo further analyses since the particles are not modified or labeled, which would typically interfere with further characterization. Another embodiment may be directed to a method of analyzing a fluid specimen from a subject suffering from a disease or condition comprising the steps of: obtaining a fluid specimen from a subject, culture, or animal model, where the fluid specimen comprises target cells of interest and non-target cells; adding said fluid specimen into a flow chamber; enriching viable target cells from non-target cells of the fluid specimen; and analyzing the viable target cells.

Abstract translation: 本公开涉及一种用于从含有靶颗粒和非靶颗粒的非均相悬浮液中富集和分析目标目标颗粒的装置和方法，其中颗粒可以是生物的或非生物的。 该方法允许所得到的靶颗粒或目标颗粒的子集进行进一步分析，因为颗粒不被修饰或标记，这通常会干扰进一步表征。 另一个实施方案可以涉及从患有疾病或病症的受试者分析流体标本的方法，包括以下步骤：从受试者，培养物或动物模型获得流体标本，其中所述流体标本包含感兴趣的靶细胞 和非靶细胞; 将流体试样加入流动室中; 从流体样本的非靶细胞中富集可行的靶细胞; 并分析可行的靶细胞。

公开(公告)号：WO2016161088A3

公开(公告)日：2016-10-06

申请号：PCT/US2016/025219

申请日：2016-03-31

Applicant: FUNDAMENTAL SOLUTIONS CORPORATION

Inventor： ZUPANCIC, Thomas, J. ,  ZENG, Lingchun ,  VEDAMOORTHY, Srikanth ,  LWANDE, Joel, S. ,  KITTLE, Joseph, D. ,  MO, Min

IPC: C12Q1/04 ,  G01N33/554 ,  G01N33/569

Abstract: The described invention relates in general to systems, devices, and methods for detecting various analytes in biological samples. An exemplary embodiment of this first system includes a living, engineered biosensor cell; a reporter protein that is engineered into and produced by the living, engineered biosensor cell and that emits a detectable signal; a signal transduction pathway engineered into or occurring naturally within the living, engineered biosensor cell; at least one type of detector molecule, wherein each detector molecule is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule and that is specific to that analyte; and a plurality of transmembrane, non-antibody signal transducing elements.

公开(公告)号：WO2015145280A1

公开(公告)日：2015-10-01

申请号：PCT/IB2015/051579

申请日：2015-03-04

Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  IBM (CHINA) INVESTMENT COMPANY LTD. ,  IBM RESEARCH GMBH

Inventor： DELAMARCHE, Emmanuel ,  TEMIZ, Yuksel

IPC: G01N33/53 ,  G01N33/554 ,  G01N33/543 ,  H01L21/00

CPC classification number: B01L3/502761 ,  B01L3/502707 ,  B01L2200/0668 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0887 ,  B01L2400/086

Abstract: A microfluidic chip (100) comprises a layer (10, 60) with an array (30) of bead trapping cavities (20) provided in that layer (10, 60), wherein each of the cavities (20) has a conic shape, defined by one or more lateral walls (21-24) that are, each, hydrophilic, and wherein each of the cavities (20) extends as a blind hole in the thickness of said layer (10, 60). Methods of fabrication of such a chip are further provided.

Abstract translation: 微流体芯片（100）包括具有设置在该层（10,60）中的珠粒捕获腔（20）的阵列（30）的层（10,60），其中每个空腔（20）具有圆锥形状， 由一个或多个侧壁（21-24）限定，每个侧壁是亲水的，并且其中每个空腔（20）作为所述层（10,60）的厚度中的盲孔延伸。 进一步提供这种芯片的制造方法。

公开(公告)号：WO2015026893A1

公开(公告)日：2015-02-26

申请号：PCT/US2014/051791

申请日：2014-08-20

Applicant: NUCLEA BIOTECHNOLOGIES, INC.

Inventor： MURACA, Patrick J.

IPC: G01N33/554

CPC classification number: G01N33/6893 ,  C07K14/4702 ,  G01N2800/04 ,  G01N2800/042 ,  G01N2800/325 ,  G01N2800/50

Abstract: Disclosed are predictive biomarkers and methods of use for the determination of insulin resistance and sensitivity, in addition to cardiovascular disease and risk associated with obesity. Methods for the stratification of patients along continuum of susceptibility to cardiometabolic risk, including prediction and progression to metabolic syndrome are also provided.

Abstract translation: 公开了用于确定胰岛素抵抗和敏感性的预测性生物标志物和方法，以及心血管疾病和与肥胖相关的风险。 还提供了对心脏代谢风险易感性持续的患者分层的方法，包括对代谢综合征的预测和进展。