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    POLYMERIC DRUG DELIVERY SYSTEMS FOR TREATMENT OF DISEASE
    1.
    发明申请
    POLYMERIC DRUG DELIVERY SYSTEMS FOR TREATMENT OF DISEASE 审中-公开
    用于治疗疾病的聚合物药物递送系统

    公开(公告)号：WO2017100533A1

    公开(公告)日：2017-06-15

    申请号：PCT/US2016/065763

    申请日：2016-12-09

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： LI, Chun ,  ZHAO, Jun ,  FLEMING, Jason

    IPC: A61K47/48 ,  A61P35/00 ,  C08F8/42

    CPC classification number: C08F8/42

    Abstract: Provided are compositions and nanoparticle formulations that may be used, e.g., to deliver a therapeutic compound to a subject. In some embodiments, the nanoparticles may be used to deliver one or more chemotherapeutic agents to treat a cancer such, e.g., as a pancreatic ductal adenocarcinoma.

    Abstract translation: 提供了可用于例如将治疗性化合物递送至受试者的组合物和纳米颗粒制剂。 在一些实施方案中，纳米颗粒可用于递送一种或多种化学治疗剂以治疗癌症，例如胰腺导管腺癌。

    THERAPEUTIC AND DIAGNOSTIC USE OF MODIFIED POLYMERIC MICROCAPSULES
    3.
    发明申请
    THERAPEUTIC AND DIAGNOSTIC USE OF MODIFIED POLYMERIC MICROCAPSULES 审中-公开
    改性聚合物微胶囊的治疗和诊断用途

    公开(公告)号：WO1994002106A1

    公开(公告)日：1994-02-03

    申请号：PCT/US1993006675

    申请日：1993-07-16

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  WALLACE, Sidney ,  YANG, David ,  WALLACE, Michael ,  LI, Chun ,  LI-REN, Kuang

    IPC: A61K09/50

    CPC classification number: A61K9/1647 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/167 ,  A61K9/1694 ,  A61K47/6925 ,  A61K49/048 ,  A61K51/1251 ,  A61K2123/00 ,  B01J13/125 ,  B01J13/20 ,  Y10T428/2985

    Abstract: The present invention relates to a highly efficient method of preparing modified microcapsules exhibiting selective targeting. These microcapsules are suitable for encapsulation or surface attachment of therapeutic and diagnostic agents. In one aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing improved targeting of encapsulated agents to specific tissue cells. Examples include encapsulation of hydrophilic radiodiagnostic agents in 1 (my)m capsules to provide improved opacification and encapsulation of cytotoxic agents in 100 (my)m capsules for chemoembolization procedures. The microcapsules are suitable for attachment of a wide range of targeting agents, including antibodies, steroids and drugs, which may be attached to the microcapsule polymer before or after formation of suitably sized microcapsules. The invention also includes hydrophilic microcapsules surface modified with hydroxyl groups. Various agents such as estrone may be attached to the microcapsules and effectively targeted to selected organs.

    Abstract translation: 本发明涉及一种制备显示出选择性靶向的改性微胶囊的高效方法。 这些微胶囊适用于治疗和诊断剂的包封或表面附着。 在本发明的一个方面，通过将氨基酸酯与聚合物缀合来改变聚合物材料的表面电荷，从而提供封装剂对特定组织细胞的改进靶向。 实例包括将亲水性放射性诊断剂包封在1（my）m胶囊中，以提供改进的不透明化和包封细胞毒性剂在100（my）m胶囊中用于化疗栓塞过程。 微胶囊适合于连接广泛范围的靶向剂，包括抗体，类固醇和药物，其可在形成适当大小的微胶囊之前或之后附着于微胶囊聚合物。 本发明还包括用羟基表面改性的亲水性微胶囊。 可以将诸如雌酮的各种试剂连接到微胶囊上并且有效地靶向选定的器官。

    DUAL MODALITY DETECTION OF APOPTOSIS
    4.
    发明申请
    DUAL MODALITY DETECTION OF APOPTOSIS 审中-公开

    公开(公告)号：WO2010028156A3

    公开(公告)日：2010-03-11

    申请号：PCT/US2009/055899

    申请日：2009-09-03

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  LI, Chun ,  XIONG, Chiyi

    Inventor： LI, Chun ,  XIONG, Chiyi

    IPC: A61K49/00 ,  A61P35/00

    Abstract: To image apoptosis in vivo , small, membrane-permeable probes comprising a caspase 3 substrate, a fluorogenic dye and a radionuclide is provided. This dual-modality probe can be cleaved by caspase upon exposure to apoptotic cells, allowing imaging of caspase 3 and 7 activities using both optical and nuclear imaging techniques. The combined use of these methods provides the opportunity for a direct correlation between in vitro and in vivo biological activities and a viable method to treat disease

    DENDRITIC POLY (AMINO ACID) CARRIERS AND METHODS OF USE
    5.
    发明申请
    DENDRITIC POLY (AMINO ACID) CARRIERS AND METHODS OF USE 审中-公开
    DENDRITIC POLY AMINO ACID CARRIERS AND METHODS OF USE

    公开(公告)号：WO2003055935A1

    公开(公告)日：2003-07-10

    申请号：PCT/US2002/040937

    申请日：2002-12-23

    Applicant: BOARD OF REGENTS - THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： LI, Chun ,  VEGA, Javier ,  WALLACE, Sidney ,  TANSEY, Wayne ,  CHARNSANGAVEJ, Chusilp

    IPC: C08G69/10

    CPC classification number: B82Y5/00 ,  A61K47/6855 ,  A61K47/6885 ,  A61K51/1268 ,  C08G69/10 ,  C08G83/003

    Abstract: The present invention concerns a design for dendritic poly (amino acid) polymer carriers, also known as nonlinear polymers, and their applications. These dendritic poly (amino acid) carriers have multiple functional groups at the polymer surface. In addition, they have heterofunctional groups on the poly (amino acid) side chains for drug or diagnostic agent attachement. They are designed to allow sufficient preservation of the binding affinity of the targeting ligand while conjugating therapeutic or diagnostic agents to the polymers. The present invention also describes methods of production of the polymer carriers and methods for the treatment or diagnosis of diseases employing the polymer carriers. The present invention also includes methods to introduce targeting moieties site-specifically to the end of polymer chains.

    Abstract translation: 本发明涉及树突状聚（氨基酸）聚合物载体的设计，也称为非线性聚合物及其应用。 这些树枝状聚（氨基酸）载体在聚合物表面具有多个官能团。 此外，它们在聚（氨基酸）侧链上具有用于药物或诊断剂附着的异官能团。 它们被设计成允许充分保留靶向配体的结合亲和力，同时将治疗剂或诊断剂与聚合物共轭。 本发明还描述了生产聚合物载体的方法和用于治疗或诊断使用聚合物载体的疾病的方法。 本发明还包括将靶向部位特异性引入到聚合物链的末端的方法。

    DIAGNOSTIC IMAGING COMPOSITIONS, THEIR METHODS OF SYNTHESIS AND USE
    6.
    发明申请
    DIAGNOSTIC IMAGING COMPOSITIONS, THEIR METHODS OF SYNTHESIS AND USE 审中-公开

    公开(公告)号：WO2002087498A3

    公开(公告)日：2002-11-07

    申请号：PCT/US2002/012510

    申请日：2002-04-19

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： LI, Chun ,  WEN, Xiaoxia ,  WU, Qing-Ping ,  WALLACE, Sydney ,  ELLIS, Lee, M.

    IPC: A61K9/127

    Abstract: Conjugate molecules comprising a ligand bonded to a polymer are disclosed. One such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treating tumors or biological receptors. These conjugate molecules may be synthesized without the necessity of preactivation of the ligand using an SCN-polymer-chelating agent precursor. Conjugate molecules incorporating an annexin V ligand are particularly useful for visualizing apoptotic cells. Conjugate molecules incorporating a C225 ligand are particularly useful for targeting tumors expressing EGFR.

    DIAGNOSTIC IMAGING COMPOSITIONS, THEIR METHODS OF SYNTHESIS AND USE
    7.
    发明申请
    DIAGNOSTIC IMAGING COMPOSITIONS, THEIR METHODS OF SYNTHESIS AND USE 审中-公开
    诊断成像组合物，其合成和使用方法

    公开(公告)号：WO2002087498A2

    公开(公告)日：2002-11-07

    申请号：PCT/US2002/012510

    申请日：2002-04-19

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

    Inventor： LI, Chun ,  WEN, Xiaoxia ,  WU, Qing-Ping ,  WALLACE, Sydney ,  ELLIS, Lee, M.

    IPC: A61K

    CPC classification number: A61K51/1093 ,  A61K47/65 ,  A61K47/6849 ,  A61K47/6883 ,  A61K47/6889 ,  A61K51/087 ,  A61K51/088 ,  A61K51/103

    Abstract: Conjugate molecules comprising a ligand bonded to a polymer are disclosed. One such conjugate molecule comprises a ligand bonded to a polymer, a chelating agent bonded to the polymer, and a radioisotope chelated to the chelating agent. The conjugate molecules may be useful in detecting and/or treating tumors or biological receptors. These conjugate molecules may be synthesized without the necessity of preactivation of the ligand using an SCN-polymer-chelating agent precursor. Conjugate molecules incorporating an annexin V ligand are particularly useful for visualizing apoptotic cells. Conjugate molecules incorporating a C225 ligand are particularly useful for targeting tumors expressing EGFR.

    Abstract translation: 公开了包含与聚合物结合的配体的共轭分子。 一种这样的共轭分子包括与聚合物键合的配体，与聚合物结合的螯合剂，以及与螯合剂螯合的放射性同位素。 缀合物分子可用于检测和/或治疗肿瘤或生物受体。 可以使用SCN-聚合物 - 螯合剂前体而不需要使配体预活化来合成这些共轭分子。 结合膜联蛋白V配体的缀合物分子对于凋亡细胞的可视化特别有用。 结合C225配体的缀合物分子特别可用于靶向表达EGFR的肿瘤。

    FUNGUS-SPECIFIC IMAGING AGENTS
    9.
    发明申请
    FUNGUS-SPECIFIC IMAGING AGENTS 审中-公开

    公开(公告)号：WO2007134229A3

    公开(公告)日：2007-11-22

    申请号：PCT/US2007/068766

    申请日：2007-05-11

    Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  LI, Chun ,  KONTOYIANNIS, Dimitrios P.

    Inventor： LI, Chun ,  KONTOYIANNIS, Dimitrios P.

    IPC: A01N37/18 ,  A61K38/00

    Abstract: The disclosure relates to an imaging composition including a fungus-specific peptide and an imaging material. Another imaging composition includes a fungus-specific peptide and a chelator able to chelate a radionuclide. The disclosure also provides to a method of detecting a fungal infection. The method includes administering an imaging agent to a patient. The imaging agent comprises a fungus-specific peptide and an imaging material. Then one may detect the imaging agent in the patient. Detecting retained imaging agent in a tissue or organ indicates fungal infection of the tissue or organ.

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