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公开(公告)号：WO2016004404A2
公开(公告)日：2016-01-07
申请号：PCT/US2015/039134
申请日：2015-07-02
Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Inventor： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , HAMILTON, Matthew , KANG, Zhijun , SOTH, Michael, P. , BURKE, Jason, P. , LE, Kang , CARROLL, Christopher, Lawrence , PALMER, Wylie , LEWIS, Richard , MCAFOOS, Timothy , CZAKO, Barbara , LIU, Gang , THEROFF, Jay , HERRERA, Zachary , YAU, Anne
IPC: C07D417/14 , A61K31/4439
CPC classification number: C07D417/14 , A61K31/4192 , A61K31/433 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/497 , A61K31/501 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D417/06 , C07D493/08
Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
Abstract translation: 本文公开了用于治疗具有式I结构的GLS1介导的疾病例如癌症的化合物和组合物：还提供了抑制人或动物受试者中的GLS1活性的方法。 / p>
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公开(公告)号：WO2016004417A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/039150
申请日：2015-07-03
Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Inventor： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , ZHIJUN, Kang , SOTH, Michael, P , BURKE, Jason, P , CARROLL, Christopher Lawrence , MCAFOOS, Timothy , PALMER, Wylie, S. , HERRERA, Zachary , HAMILTON, Matthew
IPC: C07D401/06
CPC classification number: C07D401/06 , A61K31/00 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/513 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/06 , C07D417/14 , C07D487/04
Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.
Abstract translation: 本文公开了可用于治疗GLS1介导的疾病（例如癌症）的化合物和组合物，其具有式I的结构：还提供了人或动物受试者的抑制GLS1活性的方法。
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公开(公告)号：WO2016004413A3
公开(公告)日：2016-01-07
申请号：PCT/US2015/039143
申请日：2015-07-02
Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM
Inventor： DI FRANCESCO, Maria, Emilia , JONES, Philip , HEFFERNAN, Timothy , SOTH, Michael, P. , LE, Kang , CARROLL, Christopher, Lawrence , MCAFOOS, Timothy , BURKE, Jason, P. , THEROFF, Jay , ZANG, Zhijun
IPC: C07D487/04 , A61K31/5025
Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS I mediated diseases, such as cancer, having the structure of Formula I. Methods of inhibition GLS I activity in a human or animal subject are also provided. Accordingly, the inventors herein disclose new compositions and methods for inhibiting glutaminase activity.
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4.发明申请SALTS OF HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE 审中-公开用于治疗疾病的HIF活性的杂环调节剂的盐
公开(公告)号：WO2015130790A2
公开(公告)日：2015-09-03
申请号：PCT/US2015/017533
申请日：2015-02-25
Applicant: BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM , JONES, Philip , DI FRANCESCO, Maria, Emilia , MCAFOOS, Timothy
Inventor： JONES, Philip , DI FRANCESCO, Maria, Emilia , MCAFOOS, Timothy
IPC: C07D413/14
CPC classification number: A61K31/454 , A61K31/4245 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D413/14
Abstract: The present disclosure relates to salts of heterocyclic compounds and methods that inhibit HIF pathway activity. The compounds are designed to treat or prevent cancer and other hypoxia-mediated diseases.
Abstract translation: 本公开涉及杂环化合物的盐和抑制HIF通路活性的方法。 该化合物被设计用于治疗或预防癌症和其他缺氧介导的疾病。
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