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公开(公告)号：WO2018115141A1
公开(公告)日：2018-06-28
申请号：PCT/EP2017/083854
申请日：2017-12-20
摘要： A neuromodulation apparatus for stimulating neural activity in a renal nerve of a patient is provided, the apparatus comprising a transducer for applying a signal to the renal nerve so as to produce a physiological response. Methods of treating sleep apnoea are also provided, including methods using the neuromodulation apparatus.
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公开(公告)号：WO2023003810A1
公开(公告)日：2023-01-26
申请号：PCT/US2022/037465
申请日：2022-07-18
发明人： LEWIS, Stephen J.
IPC分类号： A61K31/225 , A61P25/36 , A61K31/223
摘要： A method of treating opioid withdrawal and/or dependence in a subject in need thereof, includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine ester, a cystine ester, or an adduct, a pharmaceutically acceptable salt, a tautomer, or a solvate thereof.
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公开(公告)号：WO2019109002A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/063417
申请日：2018-11-30
发明人： JENKINS, Michael W. , LEWIS, Stephen J. , CHIEL, Hillel J. , JANSEN, Eric Duco , ZHOU, Junqi , LOTHET, Emilie , KOLA, Gjinovefa
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N2005/063 , A61N2005/0651 , A61N2005/0659 , A61N2005/067
摘要： The present disclosure relates to a system for using a light signal (e.g., an infrared (IR) light signal) for long-term modulation of peripheral nerve activity. Light generated with parameters (including intensity and time) can be applied to a peripheral nerve to achieve a target biological response. The target biological response can extend for a period after the light is applied. For example, when the light is applied for short period of time (e.g., 20 seconds), the target biological response can extend for a long period of time (e.g., over one hour).
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4.发明申请
公开(公告)号：WO2021159077A1
公开(公告)日：2021-08-12
申请号：PCT/US2021/017088
申请日：2021-02-08
IPC分类号： A61K31/445 , A61K31/45 , A61K31/452 , C07D211/94 , A61P25/36 , A61P11/00 , A61P9/02
摘要： A method of attenuating opioid induced cardio and/or respiratory depression in a subject in need thereof includes administering to the subject an amount of a composition comprising a nitroxide compound effective to attenuate the opioid induced cardio and/or respiratory depression.
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公开(公告)号：WO2019109008A1
公开(公告)日：2019-06-06
申请号：PCT/US2018/063426
申请日：2018-11-30
发明人： JENKINS, Michael W. , LEWIS, Stephen J. , CHIEL, Hillel J. , JANSEN, Eric Duco , ZHUO, Junqi , LOTHET, Emilie , KOLA, Gjinovefa
IPC分类号： A61N5/06
CPC分类号： A61N5/0622 , A61N2005/0612 , A61N2005/0659
摘要： The present disclosure relates to modulating neural activity within brainstem circuitry to evoke a certain bodily function (e.g., cardiorespiratory response) in a patient. A controller can configure a light signal (such as an infrared light signal) to deliver an amount of radiant exposure to a specific portion of the brainstem for a time. The specific portion of the brainstem can include brainstem circuitry that is the control center for the certain bodily function. The configured light signal can be delivered to the specific portion of the brainstem by an optrode for the time. During application, the light signal can deliver the amount of radiant exposure to the specific portion of the brainstem to evoke the certain bodily function.
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公开(公告)号：WO2017149436A1
公开(公告)日：2017-09-08
申请号：PCT/IB2017/051143
申请日：2017-02-27
摘要： This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post‐ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.
摘要翻译： 本公开提供了一种用于调节颈交感神经链（CSC）或上颈神经节（SCG）或SCG神经节后支链（一种或多种）中的神经活动的装置或系统，以及用于治疗 睡眠呼吸暂停，以及使用方法。
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