中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

16 records (took 0.014 seconds)

    ANTI-TNFa FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES
    1.
    发明申请
    ANTI-TNFa FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES 审中-公开
    抗TNFα基于FIBRONECTIN III型域的SCAFFOL组合物，方法和用途

    公开(公告)号：WO2010051310A2

    公开(公告)日：2010-05-06

    申请号：PCT/US2009062367

    申请日：2009-10-28

    Applicant: CENTOCOR ORTHO BIOTECH INC ,  JACOBS STEVEN ,  O'NEIL KARYN

    Inventor： JACOBS STEVEN ,  O'NEIL KARYN

    IPC: A61K38/39 ,  C12N15/12 ,  C12N15/70 ,  C40B30/04 ,  C40B40/10

    CPC classification number: G01N33/54306 ,  A61K38/39 ,  C07K14/78

    Abstract: A protein scaffold based on a consensus sequence of the tenth f?bronectin type III (FN3) repeat from human f?bronectin, preferably human Tenascin, that binds to human TNFa including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

    Abstract translation: 一种蛋白质支架，其基于来自人fβ支链淀粉（优选人腱生蛋白）的第十种β链球菌III型（FN3）重复序列的共有序列，其结合人TNFα，包括编码蛋白质支架，载体，宿主细胞的分离的核酸， 其制备和使用方法具有在诊断和/或治疗组合物，方法和装置中的应用。

    FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES
    2.
    发明申请
    FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES 审中-公开
    纤连蛋白III型基于域的支架组合物，方法和用途

    公开(公告)号：WO2010051274A3

    公开(公告)日：2010-09-10

    申请号：PCT/US2009062200

    申请日：2009-10-27

    Applicant: CENTOCOR ORTHO BIOTECH INC ,  JACOBS STEVEN ,  O'NEIL KARYN

    Inventor： JACOBS STEVEN ,  O'NEIL KARYN

    IPC: C07K16/00

    CPC classification number: C07K14/78 ,  C40B40/08 ,  C40B50/06

    Abstract: A protein scaffold based on a consensus sequence of f?bronectin type III (FN3) proteins, such as the tenth FN3 repeat from human f?bronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.

    Abstract translation: 基于纤连蛋白III型（FN3）蛋白的共有序列的蛋白质支架，如来自人纤连蛋白（人腱生蛋白）的第十个FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞， 及其制备和使用方法可用于诊断和/或治疗组合物，方法和装置。 具体而言，与IgG结合的蛋白质支架分子已被鉴定为可用于诊断和/或治疗应用。

    FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES
    3.
    发明申请
    FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES 审中-公开
    纤连蛋白III型基于域的支架组合物，方法和用途

    公开(公告)号：WO2010093627A3

    公开(公告)日：2010-10-14

    申请号：PCT/US2010023625

    申请日：2010-02-09

    Applicant: CENTOCOR ORTHO BIOTECH INC ,  JACOBS STEVEN ,  O'NEIL KARYN

    Inventor： JACOBS STEVEN ,  O'NEIL KARYN

    IPC: A61K35/14 ,  A61K38/04

    CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C40B40/08 ,  C40B50/06

    Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG bassed on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.

    Abstract translation: 基于来自人纤连蛋白的第十纤连蛋白III型（FN3）重复序列的共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用方法，具有诊断和/ 或治疗组合物，方法和装置。 特别是，基于共有序列的与IgG结合的蛋白质支架分子已被鉴定为可用于诊断和/或治疗应用。

    CYNOMOLGUS IL-13 MUTEIN PROTEINS, ANTIBODIES, COMPOSITIONS, METHODS AND USES
    10.
    发明申请
    CYNOMOLGUS IL-13 MUTEIN PROTEINS, ANTIBODIES, COMPOSITIONS, METHODS AND USES 审中-公开
    CYNOMOLGUS IL-13突变蛋白，抗体，组合物，方法和用途

    公开(公告)号：WO2008048871A3

    公开(公告)日：2008-09-12

    申请号：PCT/US2007081188

    申请日：2007-10-12

    Applicant: CENTOCOR INC ,  CONAD LESLIE ,  O'NEIL KARYN ,  FISHER DUSTI

    Inventor： CONAD LESLIE ,  O'NEIL KARYN ,  FISHER DUSTI

    IPC: C07K14/54

    CPC classification number: C07K14/5437 ,  A61K38/00 ,  G01N2333/5437

    Abstract: The present invention relates to at least one novel cynomolgus IL-13 muteins (Mut-IL-13) proteins, antibodies, including isolated nucleic acids that encode at least one Mut-IL-13 protein or antibody, Mut-IL-13 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

    Abstract translation: 本发明涉及至少一种新型食蟹猴IL-13突变蛋白（Mut-IL-13）蛋白，抗体，包括编码至少一种Mut-IL-13蛋白或抗体的分离的核酸，Mut-IL-13载体， 宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。

Patent Agency Ranking