公开(公告)号：WO2013049275A1

公开(公告)日：2013-04-04

申请号：PCT/US2012/057436

申请日：2012-09-27

Applicant: JANSSEN BIOTECH, INC. ,  DIEM, Michael ,  JACOBS, Steven

Inventor： DIEM, Michael ,  JACOBS, Steven

IPC: C40B50/00 ,  C40B40/10

CPC classification number: G01N33/6845 ,  C12N15/1044 ,  C40B30/04 ,  C40B40/08 ,  C40B50/06 ,  G01N2333/78

Abstract: Protein scaffolds and scaffold libraries based on a fibronectin type III (FN3) repeat with an alternative binding surface design, isolated nucleic acids encoding the protein scaffolds, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract translation: 基于具有替代结合表面设计的纤连蛋白III型（FN3）重复的蛋白质支架和支架文库，编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备方法可用于产生治疗分子和治疗 和疾病和病症的诊断。

公开(公告)号：WO2010051310A3

公开(公告)日：2010-05-06

申请号：PCT/US2009/062367

申请日：2009-10-28

Applicant: CENTOCOR ORTHO BIOTECH INC. ,  JACOBS, Steven ,  O'NEIL, Karyn

Inventor： JACOBS, Steven ,  O'NEIL, Karyn

IPC: C07K14/435

Abstract: A protein scaffold based on a consensus sequence of the tenth fϊbronectin type III (FN3) repeat from human fϊbronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：WO2004049042A3

公开(公告)日：2005-01-06

申请号：PCT/US0337723

申请日：2003-11-24

Applicant: OMNIGUIDE COMM INC ,  FUFLYIGIN VLADIMIR ,  ANDERSON EMILIA ,  KING WESLEY ,  FINK YOEL ,  JACOBS STEVEN A ,  SKOROBOGATIY MAKSIM

Inventor： FUFLYIGIN VLADIMIR ,  ANDERSON EMILIA ,  KING WESLEY ,  FINK YOEL ,  JACOBS STEVEN A ,  SKOROBOGATIY MAKSIM

IPC: C03B37/018 ,  C03C13/04 ,  G02B6/02 ,  G02B6/00

CPC classification number: G02B6/02304 ,  C03B37/0183 ,  C03B37/01892 ,  C03B2201/86 ,  C03B2203/16 ,  C03B2203/42 ,  C03C13/043 ,  G02B6/023 ,  G02B6/03638 ,  G02B6/03688 ,  Y02P40/57

Abstract: In general, in one aspect, the invention features a method that includes exposing a surface to a first gas composition under conditions sufficient to deposit a layer of a first chalcogenide glass (240) on the surface, and exposing the layer of the first chalcogenide glass (240) to a second glass composition under conditions sufficient to deposit a layer of a second glass (230) on the layer of the first chalcogenide glass, wherein the second glass is different from the first chalcogenide glass.

Abstract translation: 通常，在一个方面，本发明的特征在于一种方法，其包括在足以在表面上沉积第一硫族化物玻璃（240）的层的条件下将表面暴露于第一气体组合物，以及暴露第一硫族化物玻璃 （240）在足以在第一硫族化物玻璃的层上沉积第二玻璃（230）层的条件下加入到第二玻璃组合物中，其中第二玻璃不同于第一硫族化物玻璃。

公开(公告)号：WO2014098792A1

公开(公告)日：2014-06-26

申请号：PCT/US2012/070087

申请日：2012-12-17

Applicant: HEWLETT PACKARD DEVELOPMENT COMPANY, L.P. ,  JACOBS, Steven

Inventor： JACOBS, Steven

IPC: G06F1/16

CPC classification number: E05D11/082 ,  E05D3/02 ,  E05D11/0081 ,  E05D11/06 ,  E05D11/084 ,  E05Y2900/606 ,  G06F1/1616 ,  G06F1/1681 ,  Y10T16/522 ,  Y10T16/538 ,  Y10T16/53885 ,  Y10T16/54034 ,  Y10T16/54035 ,  Y10T16/54038

Abstract: A hinge assembly is disclosed herein. An example includes a first knuckle including a first wall that defines a first cavity and second knuckle including a second wall that defines a second cavity. The example also includes a friction element disposed in both the first cavity defined by the first wall of the first knuckle and the second cavity defined by the second wall of the second knuckle to both rotatably and resistively couple the first knuckle to the second knuckle by application of a force directed toward the first wall and the second wall, the friction element including a third wall that defines a third cavity. Modifications and additions to, as well as other examples of, the hinge assembly are also disclosed herein.

Abstract translation: 本文公开了铰链组件。 一个例子包括第一转向节，其包括限定第一腔的第一壁和包括限定第二腔的第二壁的第二转向节。 该实施例还包括摩擦元件，其设置在由第一转向节的第一壁限定的第一空腔和由第二转向节的第二壁限定的第二腔中，并且通过施加可旋转地和电阻地将第一转向节连接到第二转向节 指向第一壁和第二壁的力，摩擦元件包括限定第三腔的第三壁。 本文还公开了铰链组件的修改和添加以及其他示例。

公开(公告)号：WO2013085556A1

公开(公告)日：2013-06-13

申请号：PCT/US2012/026714

申请日：2012-02-27

Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. ,  DELPIER, Michael ,  WOLF, Stacy, L ,  MASSARO, Kevin, L ,  KOELKER, Daniel ,  JACOBS, Steven ,  MEHANDJIYSKY, Dimitre

Inventor： DELPIER, Michael ,  WOLF, Stacy, L ,  MASSARO, Kevin, L ,  KOELKER, Daniel ,  JACOBS, Steven ,  MEHANDJIYSKY, Dimitre

IPC: G06F1/16

CPC classification number: G06F1/1681 ,  G06F1/1616 ,  G06F1/1654 ,  G06F1/1669 ,  G06F1/1679 ,  G06F1/1683 ,  Y10T29/49002

Abstract: A first housing with a polar magnet on a first side. The first housing can include an opening on the first side. A second housing can include a sliding latch, An opposite polar magnet attached to the sliding latch. The polar magnet attracts the opposite polar magnet on the sliding latch to move the sliding latch to a latched position.

Abstract translation: 在第一侧具有极性磁体的第一壳体。 第一壳体可以包括第一侧上的开口。 第二壳体可以包括滑动闩锁，附接到滑动闩锁的相对的极性磁体。 极性磁铁吸引滑动闩锁上的相反极性磁体，以将滑动闩锁移动到锁定位置。

公开(公告)号：WO2012149439A2

公开(公告)日：2012-11-01

申请号：PCT/US2012/035613

申请日：2012-04-27

Applicant: JANSSEN BIOTECH, INC. ,  MOLECULAR PARTNERS AG ,  JACOBS, Steven A. ,  O'NEIL, Karyn T. ,  BAUMANN, Michael ,  SENNHAUSER, Gaby

Inventor： JACOBS, Steven A. ,  O'NEIL, Karyn T. ,  BAUMANN, Michael ,  SENNHAUSER, Gaby

IPC: C07K14/00 ,  A61K38/16 ,  A61P11/00 ,  A61P11/06 ,  A61P9/00 ,  A61P35/00 ,  A61P17/00 ,  C12N15/11 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N7/01 ,  C12N5/10 ,  C12P21/02

CPC classification number: C07K14/705 ,  A61K38/00 ,  C07K14/47 ,  C07K2319/70 ,  Y02A50/409 ,  Y02A50/423

Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1 ) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.

Abstract translation: IL4 / IL13结合蛋白包含结合结构域，其抑制IL4 / IL13与IL4Ralpaha和常见的γ链复合物（1型）结合并抑制IL4与IL4Rα和IL13Ralpha1复合物（2型）的结合，IL13与IL13Rα1和/或IL13Rα2的结合 ，可用于治疗癌症，炎症和其他病理状况，如过敏或纤维化病症，特别是肺部疾病。

公开(公告)号：WO2011137319A2

公开(公告)日：2011-11-03

申请号：PCT/US2011/034512

申请日：2011-04-29

Applicant: CENTOCOR ORTHO BIOTECH INC. ,  JACOBS, Steven

Inventor： JACOBS, Steven

IPC: A61K49/00 ,  C07K14/00 ,  C40B50/00 ,  C40B40/08 ,  C40B40/02 ,  C40B30/04 ,  C07H21/00 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C12N5/10 ,  A61K38/16 ,  A61P25/00 ,  A61K38/22 ,  A61P7/00 ,  A61P27/02 ,  A61P35/00 ,  A61P9/00 ,  A61P27/16 ,  A61P11/00 ,  A61P1/00 ,  A61P43/00 ,  A61P37/02 ,  A61P11/02 ,  A61P31/00

CPC classification number: C12N15/1044 ,  A61K38/00 ,  C07K14/78 ,  C07K16/18 ,  C07K2318/20 ,  Y02A50/473

Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof. The protein scaffold molecules of the present invention exhibit enhanced thermal and chemical stability while presenting six modifiable loop domains which can be engineered to form a binding partner capable of binding to a target for applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并使用它们。 本发明的蛋白质支架分子表现出增强的热和化学稳定性，同时呈现六个可修饰的环结构域，其可被工程化以形成能够与诊断和/或治疗组合物，方法和装置中的应用结合的靶标的结合配偶体。

公开(公告)号：WO2010051310A2

公开(公告)日：2010-05-06

申请号：PCT/US2009062367

申请日：2009-10-28

Applicant: CENTOCOR ORTHO BIOTECH INC ,  JACOBS STEVEN ,  O'NEIL KARYN

Inventor： JACOBS STEVEN ,  O'NEIL KARYN

IPC: A61K38/39 ,  C12N15/12 ,  C12N15/70 ,  C40B30/04 ,  C40B40/10

CPC classification number: G01N33/54306 ,  A61K38/39 ,  C07K14/78

Abstract: A protein scaffold based on a consensus sequence of the tenth f?bronectin type III (FN3) repeat from human f?bronectin, preferably human Tenascin, that binds to human TNFa including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 一种蛋白质支架，其基于来自人fβ支链淀粉（优选人腱生蛋白）的第十种β链球菌III型（FN3）重复序列的共有序列，其结合人TNFα，包括编码蛋白质支架，载体，宿主细胞的分离的核酸， 其制备和使用方法具有在诊断和/或治疗组合物，方法和装置中的应用。

公开(公告)号：WO2006135701A3

公开(公告)日：2007-05-03

申请号：PCT/US2006022349

申请日：2006-06-09

Applicant: OMNIGUIDE INC ,  SHAPIRA GIL ,  TEMELKURAN BURAK ,  MICETICH AARON ,  AHMAD ROKAN ,  AVRAHAMI YTSHAK ,  KANN YELENA ,  WEISBERG ORI ,  DELLEMANN GREGOR ,  KOLODNY URI ,  TORRES DAVID ,  ANASTASSIOU CHARALAMBOS ,  JACOBS STEVEN A ,  SHURGALIN MAX ,  FINK YOEL ,  WANG TAIRAN

Inventor： SHAPIRA GIL ,  TEMELKURAN BURAK ,  MICETICH AARON ,  AHMAD ROKAN ,  AVRAHAMI YTSHAK ,  KANN YELENA ,  WEISBERG ORI ,  DELLEMANN GREGOR ,  KOLODNY URI ,  TORRES DAVID ,  ANASTASSIOU CHARALAMBOS ,  JACOBS STEVEN A ,  SHURGALIN MAX ,  FINK YOEL ,  WANG TAIRAN

IPC: G02B6/02

CPC classification number: A61B18/22 ,  A61B18/201 ,  A61B2018/207 ,  G02B6/02304 ,  G02B6/02385 ,  G02B6/03638 ,  G02B6/03661

Abstract: In general, in one aspect, the invention features methods that include guiding radiation at a first wavelength, ?1, through a core of a photonic crystal fiber and guiding radiation at a second wavelength, ?2, through the photonic crystal fiber, wherein |? 1 - ? 2| > 100 nm.

Abstract translation: 一般来说，一方面，本发明的特征在于，包括通过光子晶体光纤的芯引导第一波长λ1的辐射并通过光子晶体光纤引导第二波长λ2的辐射的方法，其中| ？ 1 - ？ 2 | > 100nm。

公开(公告)号：WO2005096783A2

公开(公告)日：2005-10-20

申请号：PCT/US2005/012047

申请日：2005-04-08

Applicant: OMNIGUIDE COMMUNICATIONS INC. ,  TEMELKURAN, Burak ,  ANASTASSIOU, Charalambos ,  TORRES, David ,  SHAPIRA, Gil ,  SHURGALIN, Max ,  DELLEMANN, Gregor ,  WEISBERG, Ori ,  JACOBS, Steven, A. ,  WANG, Tairan ,  KOLODNY, Uri ,  RUSK, Jesse ,  PAYNE, Robert ,  FINK, Yoel ,  ULU, Gokhan

Inventor： TEMELKURAN, Burak ,  ANASTASSIOU, Charalambos ,  TORRES, David ,  SHAPIRA, Gil ,  SHURGALIN, Max ,  DELLEMANN, Gregor ,  WEISBERG, Ori ,  JACOBS, Steven, A. ,  WANG, Tairan ,  KOLODNY, Uri ,  RUSK, Jesse ,  PAYNE, Robert ,  FINK, Yoel ,  ULU, Gokhan

IPC: A61B1/018 ,  A61B18/22 ,  G02B6/02 ,  G02B6/06

CPC classification number: A61B1/018 ,  A61B18/201 ,  A61B2018/2272 ,  G02B6/02304 ,  G02B6/02385

Abstract: In general, in one aspect, the invention features systems, including a photonic crystal fiber including a core extending along a waveguide axis and a dielectric confinement region surrounding the core, the dielectric confinement region being configured to guide radiation along the waveguide axis from an input end to an output end of the photonic crystal fiber. The systems also includes a handpiece attached to the photonic crystal fiber, wherein the handpiece allows an operator to control the orientation of the output end to direct the radiation to a target location of a patient.

Abstract translation: 通常，在一个方面，本发明的特征在于系统，其包括光子晶体光纤，其包括沿着波导轴延伸的芯和围绕芯的介电限制区，所述介电限制区被配置为沿着波导轴从输入引导辐射 结束于光子晶体光纤的输出端。 该系统还包括连接到光子晶体光纤的手持件，其中手持件允许操作者控制输出端的取向以将辐射引导到患者的目标位置。